The Influence of Obesity on the Association of Obstructive Sleep Apnea and Atrial Fibrillation.
Atrial Fibrillation
Obesity
Obstructive Sleep Apnea
Journal
Sleep medicine research
ISSN: 2093-9175
Titre abrégé: Sleep Med Res
Pays: Korea (South)
ID NLM: 101589461
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
entrez:
9
9
2021
pubmed:
10
9
2021
medline:
10
9
2021
Statut:
ppublish
Résumé
The association between obstructive sleep apnea (OSA) and atrial fibrillation (AF) has been closely studied. However, obesity is a powerful confounder in the causal relationship between OSA and cardiovascular disease. The contribution of obesity in the relationship between OSA and AF remains unclear. We recruited 457 consecutive patients equally with and without AF who underwent clinically indicated diagnostic polysomnography at a single academic sleep center. Multivariable logistic regression adjusting for age, sex, hypertension, and heart failure was performed to study the independent association between OSA and AF stratified by obesity. A total of 457 patients (male: 56.2%, mean age 63.1 ± 13.3 years) was included. OSA prevalence was similar between those with and without AF (52.6% vs. 47.4%, respectively; p = 0.24). In multivariable analysis, no association was found between AF and OSA regardless of obesity status. When severe OSA (vs. non-severe OSA) was modeled as a dependent variable, AF was associated with a higher likelihood of severe OSA in non-obese patients [odds ratio (OR): 2.29, 95% confidence interval (CI): 1.23-4.35, p = 0.01], but not in obese patients (OR: 0.95, 95% CI: 0.48-1.90, p = 0.89). The association of OSA with AF was present only in the non-obese and was limited to severe OSA patients. In contrast, no association was found in obese patients. The association between OSA and AF is partly dependent on the body habitus.
Sections du résumé
BACKGROUND AND OBJECTIVE
OBJECTIVE
The association between obstructive sleep apnea (OSA) and atrial fibrillation (AF) has been closely studied. However, obesity is a powerful confounder in the causal relationship between OSA and cardiovascular disease. The contribution of obesity in the relationship between OSA and AF remains unclear.
METHODS
METHODS
We recruited 457 consecutive patients equally with and without AF who underwent clinically indicated diagnostic polysomnography at a single academic sleep center. Multivariable logistic regression adjusting for age, sex, hypertension, and heart failure was performed to study the independent association between OSA and AF stratified by obesity.
RESULTS
RESULTS
A total of 457 patients (male: 56.2%, mean age 63.1 ± 13.3 years) was included. OSA prevalence was similar between those with and without AF (52.6% vs. 47.4%, respectively; p = 0.24). In multivariable analysis, no association was found between AF and OSA regardless of obesity status. When severe OSA (vs. non-severe OSA) was modeled as a dependent variable, AF was associated with a higher likelihood of severe OSA in non-obese patients [odds ratio (OR): 2.29, 95% confidence interval (CI): 1.23-4.35, p = 0.01], but not in obese patients (OR: 0.95, 95% CI: 0.48-1.90, p = 0.89).
CONCLUSION
CONCLUSIONS
The association of OSA with AF was present only in the non-obese and was limited to severe OSA patients. In contrast, no association was found in obese patients. The association between OSA and AF is partly dependent on the body habitus.
Identifiants
pubmed: 34497733
doi: 10.17241/smr.2021.00857
pmc: PMC8423346
mid: NIHMS1726051
doi:
Types de publication
Journal Article
Langues
eng
Pagination
50-56Subventions
Organisme : NHLBI NIH HHS
ID : R21 HL140432
Pays : United States
Organisme : NHLBI NIH HHS
ID : R21 HL150502
Pays : United States
Déclaration de conflit d'intérêts
Conflicts of Interest: Authors declare no conflict of interests for this article.
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