Assessment of single-vessel cerebral blood velocity by phase contrast fMRI.
Journal
PLoS biology
ISSN: 1545-7885
Titre abrégé: PLoS Biol
Pays: United States
ID NLM: 101183755
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
17
08
2020
accepted:
28
07
2021
revised:
21
09
2021
pubmed:
10
9
2021
medline:
20
11
2021
entrez:
9
9
2021
Statut:
epublish
Résumé
Current approaches to high-field functional MRI (fMRI) provide 2 means to map hemodynamics at the level of single vessels in the brain. One is through changes in deoxyhemoglobin in venules, i.e., blood oxygenation level-dependent (BOLD) fMRI, while the second is through changes in arteriole diameter, i.e., cerebral blood volume (CBV) fMRI. Here, we introduce cerebral blood flow-related velocity-based fMRI, denoted CBFv-fMRI, which uses high-resolution phase contrast (PC) MRI to form velocity measurements of flow. We use CBFv-fMRI in measure changes in blood velocity in single penetrating microvessels across rat parietal cortex. In contrast to the venule-dominated BOLD and arteriole-dominated CBV fMRI signals, CBFv-fMRI is comparable from both arterioles and venules. A single fMRI platform is used to map changes in blood pO2 (BOLD), volume (CBV), and velocity (CBFv). This combined high-resolution single-vessel fMRI mapping scheme enables vessel-specific hemodynamic mapping in animal models of normal and diseased states and further has translational potential to map vascular dementia in diseased or injured human brains with ultra-high-field fMRI.
Identifiants
pubmed: 34499636
doi: 10.1371/journal.pbio.3000923
pii: PBIOLOGY-D-20-02507
pmc: PMC8454982
doi:
Substances chimiques
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e3000923Subventions
Organisme : NINDS NIH HHS
ID : R35 NS097265
Pays : United States
Organisme : NINDS NIH HHS
ID : RF1 NS113278
Pays : United States
Organisme : NINDS NIH HHS
ID : U19 NS123717
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS120594
Pays : United States
Organisme : NIMH NIH HHS
ID : S10 MH124733
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH111438
Pays : United States
Organisme : NIH HHS
ID : S10 OD028616
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS121642
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS122904
Pays : United States
Commentaires et corrections
Type : ErratumIn
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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