Surface megalin expression is a target to the inhibitory effect of bradykinin on the renal albumin endocytosis.
Albumins
/ metabolism
Animals
Bradykinin
/ pharmacology
Cell Line
Endocytosis
/ drug effects
Enzyme Activation
Kidney Tubules, Proximal
/ drug effects
LLC-PK1 Cells
Low Density Lipoprotein Receptor-Related Protein-2
/ metabolism
Protein Kinase C
/ metabolism
Receptor, Bradykinin B2
/ metabolism
Swine
Albuminuria
Bradykinin
Endocytosis
G protein‐coupled receptor
Kidney
Protein kinase C
Journal
Peptides
ISSN: 1873-5169
Titre abrégé: Peptides
Pays: United States
ID NLM: 8008690
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
02
08
2021
revised:
02
09
2021
accepted:
03
09
2021
pubmed:
10
9
2021
medline:
24
3
2022
entrez:
9
9
2021
Statut:
ppublish
Résumé
Megalin-mediated albumin endocytosis plays a critical role in albumin reabsorption in proximal tubule (PT) epithelial cells (PTECs). Some studies have pointed out the modulatory effect of bradykinin (BK) on urinary protein excretion, but its role in PT protein endocytosis has not yet been determined. Here, we studied the possible correlation between BK and albumin endocytosis in PT. Using LLC-PK1 cells, a model of PTECs, we showed that BK specifically inhibited megalin-mediated albumin endocytosis. This inhibitory effect of BK was mediated by B2 receptor (B2R) because it was abolished by HOE140, an antagonist of B2R, but it was not affected by Lys-des-Arg
Identifiants
pubmed: 34500007
pii: S0196-9781(21)00154-6
doi: 10.1016/j.peptides.2021.170646
pii:
doi:
Substances chimiques
Albumins
0
Low Density Lipoprotein Receptor-Related Protein-2
0
Receptor, Bradykinin B2
0
Protein Kinase C
EC 2.7.11.13
Bradykinin
S8TIM42R2W
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
170646Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.