Dental phenotype in Crouzon syndrome: A controlled radiographic study in 22 patients.
Craniofacial dysostosis
Crouzon syndrome
Dental morphology
Morphometrics
Receptor Fibroblast Growth Factor, type 2
Tooth phenotype
Journal
Archives of oral biology
ISSN: 1879-1506
Titre abrégé: Arch Oral Biol
Pays: England
ID NLM: 0116711
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
28
09
2020
revised:
25
08
2021
accepted:
28
08
2021
pubmed:
10
9
2021
medline:
13
10
2021
entrez:
9
9
2021
Statut:
ppublish
Résumé
This retrospective radiographic controlled study investigates the dental phenotype in patients with Crouzon syndrome to determine if differences are observed as suggested by the FGFR2 We assessed dental phenotype using dedicated linear measurements in 22 children with Crouzon syndrome and compared tooth morphology in both primary and permanent dentitions to an age-matched control group. Descriptive statistics were performed with "Sex" and "Age" as covariates for the permanent tooth models and "Sex" only for the primary tooth models, to take into account potential confounding factors. We showed that permanent but not primary tooth dimensions were globally reduced in Crouzon syndrome, without microdontia. In permanent dentition, crown height, mesiodistal and faciolingual cervical diameters were reduced by 6.3%, 5.7% and 5.5% respectively (p < 0.05). Our results underline the implication of Fibroblast Growth Factor Receptor 2 (FGFR2) in dental development of humans and contribute to support FGFR2
Identifiants
pubmed: 34500259
pii: S0003-9969(21)00216-8
doi: 10.1016/j.archoralbio.2021.105253
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105253Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.