Absorption, distribution, metabolism, and excretion of [

Administration, Oral Animals Benzofurans / administration & dosage Carbon Radioisotopes / administration & dosage Chromatography, High Pressure Liquid Feces / chemistry Female Male Mass Spectrometry Rats Rats, Sprague-Dawley Tissue Distribution
3-n-butylphthalide (NBP) Mass balance Metabolism Pharmacokinetics Tissue distribution [(14)C]NBP

Journal

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
ISSN: 1873-376X
Titre abrégé: J Chromatogr B Analyt Technol Biomed Life Sci
Pays: Netherlands
ID NLM: 101139554

Informations de publication

Date de publication:
01 Sep 2021
Historique:
received: 08 07 2021
revised: 19 08 2021
accepted: 25 08 2021
pubmed: 10 9 2021
medline: 27 1 2022
entrez: 9 9 2021
Statut: ppublish

Résumé

3-n-Butylphthalide (NBP) has a considerable neuroprotective effect and is currently used for the treatment of ischemic stroke. NBP was launched on the market in 2004. However, information on its metabolism in humans and preclinical animal models is insufficient. Although the metabolism of unradiolabeled NBP in humans has been reported, the quantitative metabolite profile, blood-to-plasma radioactivity concentration ratio (B/P), and tissue distribution of this drug remain unclear. We evaluated the pharmacokinetics, tissue distribution, mass balance, and metabolism of NBP in rats after a single oral dose of 60 mg/kg (100 μCi/kg) [

Identifiants

DOI: 10.1016/j.jchromb.2021.122915 PMID: 34500404
pubmed: 34500404
pii: S1570-0232(21)00396-2
doi: 10.1016/j.jchromb.2021.122915
pii:
doi:

Substances chimiques

Benzofurans 0
Carbon Radioisotopes 0
3-n-butylphthalide 822Q956KGM

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

122915

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Junjun Tian (J)

Department of Chemistry, College of Sciences, Shanghai University, Shanghai 200444, PR China; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, PR China. Electronic address: joint-tianjunjun@simm.ac.cn.

Peng Lei (P)

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, PR China. Electronic address: plei@simm.ac.cn.

Yifei He (Y)

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, PR China. Electronic address: s20-heyifei@simm.ac.cn.

Ning Zhang (N)

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, PR China. Electronic address: zhangning1@simm.ac.cn.

Xinyu Ge (X)

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, PR China. Electronic address: j20-gexinyu-nj@simm.ac.cn.

Liqiang Luo (L)

Department of Chemistry, College of Sciences, Shanghai University, Shanghai 200444, PR China. Electronic address: luck@shu.edu.cn.

Shu Yan (S)

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, PR China. Electronic address: yanshu@simm.ac.cn.

Xingxing Diao (X)

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, PR China. Electronic address: xxdiao@simm.ac.cn.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie orale › Absorption, distribution, metabolism, and...
questionsmedicales.fr › Eucaryotes › Animaux › Absorption, distribution, metabolism, and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzofuranes › Absorption, distribution, metabolism, and...
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes du carbone › Absorption, distribution, metabolism, and...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase liquide à haute performance › Absorption, distribution, metabolism, and...
questionsmedicales.fr › Liquides et sécrétions biologiques › Fèces › Absorption, distribution, metabolism, and...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Absorption, distribution, metabolism, and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Absorption, distribution, metabolism, and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Absorption, distribution, metabolism, and...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Absorption, distribution, metabolism, and...