Golgi stress response: A regulatory mechanism of Golgi function.
CREB3
ETS
HSP47
PG
TFE3
mucin pathway
Journal
BioFactors (Oxford, England)
ISSN: 1872-8081
Titre abrégé: Biofactors
Pays: Netherlands
ID NLM: 8807441
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
15
07
2021
accepted:
25
08
2021
pubmed:
10
9
2021
medline:
25
2
2022
entrez:
9
9
2021
Statut:
ppublish
Résumé
The organelle of eukaryotes is a finely regulated system. Once disturbed, it activates the specific autoregulatory systems, namely, organelle autoregulation. Among which, the Golgi stress response accounts for one. When the abundance and capacity of the Golgi apparatus are insufficient compared with cellular demand, the Golgi stress response is activated to enhance the function of the Golgi apparatus. Although the molecular mechanism of the Golgi stress response has not been well characterized yet, it seems to be an important part of the mammalian stress response. In this review, we discuss the current status of research on the six pathways of the mammalian Golgi stress response (the TFE3, heat shock protein 47, CREB3, E26 transformation specific, proteoglycan, and mucin pathways), which regulate the general function of the Golgi apparatus, anti-apoptosis, pro-apoptosis, proteoglycan glycosylation, and mucin glycosylation, respectively.
Substances chimiques
Mucins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
964-974Subventions
Organisme : Hunan Province Natural Science Foundation
ID : 2019JJ40255
Organisme : Hunan Province Natural Science Foundation
ID : 2021JJ40939
Organisme : National Natural Science Foundation of China
ID : 81973326
Informations de copyright
© 2021 International Union of Biochemistry and Molecular Biology.
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