RNA Dynamics in Alzheimer's Disease.
Alzheimer’s disease
RNA binding proteins
RNA processing
alternative splicing
circRNAs
lncRNAs
miRNAs
neurodegenerative diseases
post-transcriptional regulation
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
24 Aug 2021
24 Aug 2021
Historique:
received:
16
07
2021
revised:
09
08
2021
accepted:
17
08
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
24
9
2021
Statut:
epublish
Résumé
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder that heavily burdens healthcare systems worldwide. There is a significant requirement to understand the still unknown molecular mechanisms underlying AD. Current evidence shows that two of the major features of AD are transcriptome dysregulation and altered function of RNA binding proteins (RBPs), both of which lead to changes in the expression of different RNA species, including microRNAs (miRNAs), circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), and messenger RNAs (mRNAs). In this review, we will conduct a comprehensive overview of how RNA dynamics are altered in AD and how this leads to the differential expression of both short and long RNA species. We will describe how RBP expression and function are altered in AD and how this impacts the expression of different RNA species. Furthermore, we will also show how changes in the abundance of specific RNA species are linked to the pathology of AD.
Identifiants
pubmed: 34500547
pii: molecules26175113
doi: 10.3390/molecules26175113
pmc: PMC8433936
pii:
doi:
Substances chimiques
MicroRNAs
0
RNA, Circular
0
RNA, Long Noncoding
0
RNA, Messenger
0
RNA
63231-63-0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerio de Ciencia, Innovación y Universidades
ID : PID2019-108580RA-I00
Organisme : Ministerio de Ciencia e Innovación
ID : RYC2018-024564-I
Références
Aging Clin Exp Res. 2021 Apr;33(4):747-758
pubmed: 31583531
Nat Rev Genet. 2021 Mar;22(3):185-198
pubmed: 33235359
Pharmacol Res. 2020 May;155:104729
pubmed: 32126270
J Alzheimers Dis. 2019;67(3):875-891
pubmed: 30689565
Acta Neuropathol Commun. 2020 Apr 29;8(1):61
pubmed: 32349792
Mol Neurodegener. 2008 Aug 06;3:10
pubmed: 18684319
BMC Med Genomics. 2019 Jan 31;12(Suppl 1):13
pubmed: 30704480
Cell Rep. 2019 Dec 24;29(13):4377-4388.e4
pubmed: 31875547
Nat Med. 2020 May;26(5):769-780
pubmed: 32284590
PLoS One. 2016 Mar 07;11(3):e0150211
pubmed: 26949937
Nat Genet. 1996 Nov;14(3):269-76
pubmed: 8896555
Nat Neurosci. 2021 Feb;24(2):276-287
pubmed: 33432193
Int J Clin Exp Pathol. 2015 Feb 01;8(2):1565-74
pubmed: 25973041
Alzheimers Dement. 2018 Apr;14(4):535-562
pubmed: 29653606
Brain Res. 2007 Dec 12;1184:284-94
pubmed: 17963732
J Biol Chem. 2010 Jun 11;285(24):18344-51
pubmed: 20395292
Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10679-84
pubmed: 17553964
Mol Cell. 2014 Oct 2;56(1):55-66
pubmed: 25242144
Nat Med. 2008 Jul;14(7):723-30
pubmed: 18587408
Nature. 2001 Jan 18;409(6818):363-6
pubmed: 11201747
iScience. 2019 Oct 25;20:248-264
pubmed: 31593839
Mol Biol Cell. 1992 Oct;3(10):1141-54
pubmed: 1421571
Biomarkers. 2014 Jun;19(4):259-68
pubmed: 24678935
J Alzheimers Dis. 2015;45(3):837-49
pubmed: 25624420
Physiol Rev. 2021 Jul 1;101(3):1309-1370
pubmed: 33000986
Neurodegener Dis. 2005;2(6):277-83
pubmed: 16909010
Brain Res Bull. 2012 Sep 1;88(6):596-601
pubmed: 22721728
J Biol Chem. 2012 Sep 7;287(37):31298-310
pubmed: 22733824
Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16562-7
pubmed: 24023061
Adv Exp Med Biol. 2015;822:11-5
pubmed: 25416971
Curr Neurol Neurosci Rep. 2008 Sep;8(5):384-91
pubmed: 18713574
Acta Neuropathol. 1991;82(4):239-59
pubmed: 1759558
Eur J Neurosci. 2007 Nov;26(9):2444-57
pubmed: 17970741
Front Mol Neurosci. 2020 May 29;13:78
pubmed: 32547363
J Neurosci. 2008 Jan 30;28(5):1213-23
pubmed: 18234899
Front Aging Neurosci. 2016 Jun 14;8:140
pubmed: 27378912
Science. 2009 Feb 27;323(5918):1208-1211
pubmed: 19251628
Exp Mol Med. 2009 Sep 30;41(9):611-7
pubmed: 19478559
Nature. 2020 May;581(7808):303-309
pubmed: 32214235
J Neurosci Methods. 2010 Nov 30;193(2):189-202
pubmed: 20800617
Nat Genet. 1996 Nov;14(3):285-91
pubmed: 8896557
Neurobiol Dis. 2009 Mar;33(3):422-8
pubmed: 19110058
Hum Mol Genet. 1999 Aug;8(8):1529-40
pubmed: 10401002
Cell. 2015 Mar 12;160(6):1061-71
pubmed: 25728668
Science. 2021 Feb 26;371(6532):
pubmed: 33632820
Neurosci Lett. 2019 Jul 13;705:183-194
pubmed: 31028844
Neurology. 2000 Jun 13;54(11):2072-7
pubmed: 10851365
FEBS Lett. 2005 Oct 31;579(26):5822-9
pubmed: 16214139
Hum Mol Genet. 2011 Oct 15;20(20):4016-24
pubmed: 21807765
Sci Rep. 2018 Mar 9;8(1):4282
pubmed: 29523845
Nat Rev Mol Cell Biol. 2017 Jan;18(1):18-30
pubmed: 27677860
Biochem Biophys Res Commun. 2006 Dec 22;351(3):602-11
pubmed: 17084815
Acta Neuropathol. 2011 Feb;121(2):171-81
pubmed: 21170538
J Alzheimers Dis. 2014;42(4):1261-7
pubmed: 25024331
Nature. 2019 Jun;570(7761):332-337
pubmed: 31042697
Cell. 2014 Sep 25;159(1):134-147
pubmed: 25242744
Neuron. 2008 Apr 10;58(1):10-4
pubmed: 18400158
Front Genet. 2013 Dec 31;4:307
pubmed: 24427167
Nat Neurosci. 2018 Jun;21(6):811-819
pubmed: 29802388
Neurobiol Aging. 2019 Feb;74:225-233
pubmed: 30497016
BMC Med Genomics. 2019 May 9;12(1):60
pubmed: 31072331
J Alzheimers Dis. 2010;21(1):75-9
pubmed: 20413881
Cell Rep. 2014 Jun 12;7(5):1401-1409
pubmed: 24857657
Ann N Y Acad Sci. 1996 Jan 17;777:281-7
pubmed: 8624099
Aging (Albany NY). 2018 Feb 15;10(2):253-265
pubmed: 29448241
Trends Neurosci. 2015 Apr;38(4):226-36
pubmed: 25765321
Mol Neurobiol. 2019 Sep;56(9):6156-6167
pubmed: 30734227
Science. 2002 Jul 19;297(5580):353-6
pubmed: 12130773
Cells. 2020 Sep 29;9(10):
pubmed: 33003364
Genome Res. 2015 Oct;25(10):1491-8
pubmed: 26430159
Acta Neuropathol Commun. 2018 Aug 1;6(1):71
pubmed: 30068389
Front Cell Neurosci. 2013 Nov 07;7:203
pubmed: 24223537
Comput Struct Biotechnol J. 2018 Nov 14;16:523-531
pubmed: 30524667
Neurobiol Dis. 2011 Feb;41(2):308-17
pubmed: 20888417
Aging Dis. 2019 Dec 1;10(6):1293-1301
pubmed: 31788340
PLoS Genet. 2013;9(9):e1003777
pubmed: 24039610
Am J Hum Genet. 1999 Sep;65(3):664-70
pubmed: 10441572
Science. 2016 Jun 24;352(6293):1586-90
pubmed: 27339989
Nat Neurosci. 2019 Dec;22(12):2087-2097
pubmed: 31768052
Genomics. 2019 Jul;111(4):936-949
pubmed: 29879491
Stem Cell Rev Rep. 2012 Dec;8(4):1129-37
pubmed: 23054963
Nat Genet. 1996 Nov;14(3):277-84
pubmed: 8896556
Mol Psychiatry. 2021 Oct;26(10):5636-5657
pubmed: 31942037
Cell Physiol Biochem. 2017;42(3):1213-1226
pubmed: 28683457
PLoS Biol. 2017 Jul 6;15(7):e2002183
pubmed: 28683104
Nat Commun. 2018 Apr 30;9(1):1726
pubmed: 29712923
Nat Neurosci. 2021 Apr;24(4):584-594
pubmed: 33723434
PLoS One. 2012;7(4):e35678
pubmed: 22558197
Sci Adv. 2020 Aug 21;6(34):eaaz2978
pubmed: 32923614
Nature. 2018 Mar 22;555(7697):524-528
pubmed: 29539641
Science. 2008 Mar 21;319(5870):1668-72
pubmed: 18309045
Sci Rep. 2019 Dec 6;9(1):18509
pubmed: 31811163
Alzheimers Dement. 2016 Mar;12(3):292-323
pubmed: 27012484
Nat Rev Neurosci. 2016 Jan;17(1):5-21
pubmed: 26631930
EMBO J. 2013 Apr 3;32(7):923-5
pubmed: 23463100
Neurobiol Aging. 2019 Sep;81:116-126
pubmed: 31280115
Hum Mol Genet. 2010 Oct 15;19(20):3959-69
pubmed: 20660113
Cell Rep. 2019 Jul 23;28(4):1103-1116.e4
pubmed: 31340147
RNA. 2014 Dec;20(12):1829-42
pubmed: 25404635
J Biol Chem. 2005 Mar 25;280(12):11648-55
pubmed: 15659387
Nat Genet. 2018 Nov;50(11):1584-1592
pubmed: 30297968
Front Cell Neurosci. 2019 Jul 09;13:296
pubmed: 31338022
Neurogenetics. 2004 Dec;5(4):223-7
pubmed: 15480879
Neurobiol Aging. 2014 Feb;35(2):345-56
pubmed: 24064186
Science. 2009 Feb 27;323(5918):1205-8
pubmed: 19251627
Nat Rev Neurosci. 2019 Nov;20(11):649-666
pubmed: 31582840
Cell Rep. 2015 May 12;11(6):967-976
pubmed: 25937287
Biochem Biophys Res Commun. 2011 Jan 28;404(4):889-95
pubmed: 21172309
Biochim Biophys Acta. 2012 Jul;1823(7):1170-7
pubmed: 22580042
Int J Mol Med. 2018 Mar;41(3):1665-1672
pubmed: 29286086
Science. 2018 May 25;360(6391):
pubmed: 29674432
Dis Model Mech. 2013 Mar;6(2):424-33
pubmed: 22996644
Nat Neurosci. 2020 Mar;23(3):311-322
pubmed: 32112059
Nat Commun. 2020 Nov 2;11(1):5540
pubmed: 33139712
Cell Cycle. 2019 Sep;18(18):2197-2214
pubmed: 31373242
Cell. 2004 Apr 2;117(1):1-3
pubmed: 15066275
Nat Rev Genet. 2012 Mar 13;13(4):227-32
pubmed: 22411467
Acta Neuropathol. 2020 Sep;140(3):317-339
pubmed: 32577828
Cell. 2018 Mar 22;173(1):20-51
pubmed: 29570994
Ann Neurol. 2007 May;61(5):435-45
pubmed: 17469117
Int J Geriatr Psychiatry. 2018 Jul;33(7):980-986
pubmed: 29635818
Mol Biosyst. 2009 Dec;5(12):1512-26
pubmed: 20023718
Cell. 2013 Aug 15;154(4):727-36
pubmed: 23953108
Front Mol Neurosci. 2020 Oct 28;13:134
pubmed: 33192286
Oxid Med Cell Longev. 2017;2017:2398696
pubmed: 28593022
J Chem Neuroanat. 2019 Jul;98:87-96
pubmed: 30959172
Sci Rep. 2016 Jan 28;6:19946
pubmed: 26818210
Int J Alzheimers Dis. 2020 Apr 1;2020:5380346
pubmed: 32308993
Am J Transl Res. 2017 Mar 15;9(3):1381-1391
pubmed: 28386363
Neurol Res. 2018 Sep;40(9):795-804
pubmed: 29902125
Cell Mol Life Sci. 2019 Aug;76(15):3005-3018
pubmed: 31006037
Mech Ageing Dev. 1984 Jan;24(1):101-17
pubmed: 6141331
Cell. 2012 May 11;149(4):753-67
pubmed: 22579281
J Biol Chem. 2018 Jul 13;293(28):11047-11066
pubmed: 29802200
Nat Biotechnol. 2018 Jan;36(1):70-80
pubmed: 29227469
Science. 2004 Jan 2;303(5654):95-8
pubmed: 14631048
J Biol Chem. 2009 Jan 23;284(4):1971-81
pubmed: 18986979
Exp Cell Res. 2016 May 1;343(2):248-257
pubmed: 27038654
Acta Neuropathol. 2007 Jul;114(1):5-22
pubmed: 17579875
Annu Rev Biochem. 2015;84:291-323
pubmed: 25784052
J Biol Chem. 2017 Jun 23;292(25):10600-10612
pubmed: 28487370
Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6415-20
pubmed: 18434550
Nat Genet. 2021 Mar;53(3):392-402
pubmed: 33589840
Nature. 2013 Mar 21;495(7441):333-8
pubmed: 23446348
PLoS One. 2018 May 10;13(5):e0197329
pubmed: 29746584
Cell. 2018 Aug 9;174(4):1038-1038.e1
pubmed: 30096304
Brain Res. 2014 Oct 10;1584:52-8
pubmed: 25108040
Nat Rev Genet. 2007 Jul;8(7):533-43
pubmed: 17572691
Acta Neuropathol. 2021 Jul;142(1):159-177
pubmed: 33934221
Neurobiol Aging. 2012 Mar;33(3):522-34
pubmed: 20619502
Genom Data. 2014 Sep 07;2:290-2
pubmed: 26484111
Proteomics. 2016 Dec;16(23):3042-3053
pubmed: 27718298
Acta Neuropathol Commun. 2018 Oct 26;6(1):113
pubmed: 30367664
Genome Biol. 2014 Jan 08;15(1):R12
pubmed: 24401661
Neuron. 2021 May 19;109(10):1675-1691.e9
pubmed: 33848474
J Neuropathol Exp Neurol. 2011 Nov;70(11):960-9
pubmed: 22002422
Cell. 2012 May 11;149(4):768-79
pubmed: 22579282
Exp Ther Med. 2016 Aug;12(2):809-814
pubmed: 27446280
Aging (Albany NY). 2019 Dec 20;11(24):12002-12031
pubmed: 31860870
Wiley Interdiscip Rev RNA. 2017 Jan;8(1):
pubmed: 27659605
Brain Pathol. 2014 Jul;24(4):344-51
pubmed: 24571648
Brain. 2011 Sep;134(Pt 9):2595-609
pubmed: 21856723
Cell. 2003 Oct 17;115(2):209-16
pubmed: 14567918
RNA. 2009 Nov;15(11):2013-27
pubmed: 19767420
Nature. 2003 Sep 25;425(6956):415-9
pubmed: 14508493
Cell Rep. 2015 May 19;11(7):1134-46
pubmed: 25959826
Genome Res. 2011 Oct;21(10):1572-82
pubmed: 21846794
Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7285-90
pubmed: 26060301
J Alzheimers Dis. 2019;67(2):571-581
pubmed: 30584150
Cell Rep. 2016 May 17;15(7):1455-1466
pubmed: 27160897
J Atheroscler Thromb. 1997;4(1):20-6
pubmed: 9583350
Neurobiol Aging. 2015 Feb;36(2):1221.e15-28
pubmed: 25281018
Front Mol Neurosci. 2021 Dec 03;14:742790
pubmed: 34924950
J Neurosci. 2012 Jun 13;32(24):8270-83
pubmed: 22699908
Acta Neuropathol. 2007 May;113(5):521-33
pubmed: 17219193
PLoS One. 2011 Jan 21;6(1):e16266
pubmed: 21283692
Nat Genet. 2019 Mar;51(3):414-430
pubmed: 30820047
J Neurochem. 2013 Aug;126(3):305-11
pubmed: 23406382
Mol Cell Proteomics. 2015 Nov;14(11):3000-14
pubmed: 26269332
Yonsei Med J. 2019 Jul;60(7):640-650
pubmed: 31250578
PLoS Genet. 2021 Feb 25;17(2):e1009363
pubmed: 33630843
Alzheimers Res Ther. 2019 Aug 9;11(1):71
pubmed: 31399126
Nat Genet. 2019 Mar;51(3):404-413
pubmed: 30617256
Nature. 2015 Apr 2;520(7545):90-3
pubmed: 25807486
Acta Neuropathol. 2012 Nov;124(5):717-32
pubmed: 22993125
Nat Commun. 2020 Nov 23;11(1):5950
pubmed: 33230138
Trends Biochem Sci. 2008 Mar;33(3):141-50
pubmed: 18291657
Nature. 2013 Mar 21;495(7441):384-8
pubmed: 23446346
Front Bioeng Biotechnol. 2019 Sep 11;7:222
pubmed: 31572720
PLoS One. 2014 Jul 09;9(7):e102140
pubmed: 25006803
Biochim Biophys Acta. 2016 Dec;1863(12):3125-3147
pubmed: 27713097
J Biol Chem. 2003 Feb 28;278(9):6748-54
pubmed: 12493737
Aging Cell. 2019 Dec;18(6):e13035
pubmed: 31532069
Neurol Res. 2019 Jun;41(6):489-497
pubmed: 31014193
DNA Cell Biol. 2018 Mar;37(3):220-226
pubmed: 29298096
Nat Genet. 2007 Feb;39(2):168-77
pubmed: 17220890
Cell. 2003 Oct 17;115(2):199-208
pubmed: 14567917
Front Aging Neurosci. 2018 May 23;10:153
pubmed: 29875655
J Alzheimers Dis. 2018;61(2):561-570
pubmed: 29226865
Hum Mol Genet. 2020 Oct 10;29(17):2899-2919
pubmed: 32803238
Front Mol Neurosci. 2017 Apr 04;10:89
pubmed: 28420962
Genes Dev. 2017 Aug 1;31(15):1509-1528
pubmed: 28912172
Nat Neurosci. 2012 Jun;15(6):827-35
pubmed: 22610069
Nature. 2004 Nov 11;432(7014):235-40
pubmed: 15531877
J Biol Chem. 1993 Feb 15;268(5):3414-9
pubmed: 8429017
Nat Neurosci. 2019 Nov;22(11):1903-1912
pubmed: 31591557
FEBS J. 2017 Apr;284(7):1096-1109
pubmed: 28296235
Trends Cell Biol. 2016 Sep;26(9):668-679
pubmed: 27289443
Neurochem Res. 1992 Jun;17(6):591-7
pubmed: 1603265
Genes (Basel). 2016 Dec 05;7(12):
pubmed: 27929395
Nat Biotechnol. 2014 May;32(5):453-61
pubmed: 24811520
Neurobiol Dis. 2017 Oct;106:1-13
pubmed: 28630030
Mol Neurodegener. 2018 Oct 4;13(1):52
pubmed: 30286791
Nat Commun. 2021 Jun 2;12(1):3291
pubmed: 34078905
Mol Med Rep. 2014 Sep;10(3):1275-81
pubmed: 24970022
J Alzheimers Dis. 2017;60(4):1365-1377
pubmed: 29036818
Acta Neuropathol Commun. 2020 Jun 3;8(1):79
pubmed: 32493451
Nat Commun. 2018 Aug 22;9(1):3358
pubmed: 30135423
J Neurochem. 2011 Jan;116(2):240-7
pubmed: 21062284
Nat Rev Mol Cell Biol. 2021 Feb;22(2):96-118
pubmed: 33353982
Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25800-25809
pubmed: 32989152
Neurosci Bull. 2019 Oct;35(5):877-888
pubmed: 30887246
Aging (Albany NY). 2013 Dec;5(12):925-38
pubmed: 24368295
Mol Neurobiol. 2020 Jul;57(7):3183-3194
pubmed: 32504417
Neurobiol Aging. 2015 Nov;36(11):2925-2931
pubmed: 26318290
Mol Psychiatry. 2019 Mar;24(3):345-363
pubmed: 30470799
Dement Geriatr Cogn Dis Extra. 2013 Mar 12;3(1):74-85
pubmed: 23637700
Eur J Med Chem. 2016 Jan 1;107:63-81
pubmed: 26562543
Mol Cell. 2018 Feb 15;69(4):622-635.e6
pubmed: 29429924
Ann Clin Transl Neurol. 2019 Mar 10;6(4):762-777
pubmed: 31020001
Mol Ther. 2021 Jun 2;29(6):2167-2181
pubmed: 33578037
Genomics. 1997 Mar 15;40(3):415-24
pubmed: 9073509
Cell Rep. 2019 Oct 8;29(2):301-316.e10
pubmed: 31597093
Cold Spring Harb Perspect Med. 2012 Jan;2(1):a006304
pubmed: 22315713
Cell Mol Neurobiol. 2020 May;40(4):531-546
pubmed: 31691877
Oncogene. 2006 Oct 9;25(46):6176-87
pubmed: 17028597
Brain Res. 2007 Aug 3;1161:116-23
pubmed: 17586478
Sci Rep. 2020 Mar 23;10(1):5225
pubmed: 32251304
Cell Syst. 2017 Jan 25;4(1):60-72.e4
pubmed: 27989508