The Role of Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Leukemia.
acute lymphoblastic leukemia
acute myeloid leukemia
allogeneic stem cell transplantation
alternative donors
conditioning regimen
minimal residual disease
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
25 Aug 2021
25 Aug 2021
Historique:
received:
05
07
2021
revised:
08
08
2021
accepted:
19
08
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
11
9
2021
Statut:
epublish
Résumé
Allogeneic hematopoietic stem cell transplantation (HSCT) offers potentially curative treatment for many children with high-risk or relapsed acute leukemia (AL), thanks to the combination of intense preparative radio/chemotherapy and the graft-versus-leukemia (GvL) effect. Over the years, progress in high-resolution donor typing, choice of conditioning regimen, graft-versus-host disease (GvHD) prophylaxis and supportive care measures have continuously improved overall transplant outcome, and recent successes using alternative donors have extended the potential application of allotransplantation to most patients. In addition, the importance of minimal residual disease (MRD) before and after transplantation is being increasingly clarified and MRD-directed interventions may be employed to further ameliorate leukemia-free survival after allogeneic HSCT. These advances have occurred in parallel with continuous refinements in chemotherapy protocols and the development of targeted therapies, which may redefine the indications for HSCT in the coming years. This review discusses the role of HSCT in childhood AL by analysing transplant indications in both acute lymphoblastic and acute myeloid leukemia, together with current and most promising strategies to further improve transplant outcome, including optimization of conditioning regimen and MRD-directed interventions.
Identifiants
pubmed: 34501237
pii: jcm10173790
doi: 10.3390/jcm10173790
pmc: PMC8432223
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Blood. 2001 May 15;97(10):2962-71
pubmed: 11342418
Br J Haematol. 2017 Apr;177(1):116-126
pubmed: 28240765
Bone Marrow Transplant. 2015 Sep;50(9):1173-9
pubmed: 25961775
N Engl J Med. 2018 Feb 1;378(5):439-448
pubmed: 29385370
Blood Cancer J. 2019 May 21;9(6):51
pubmed: 31113932
Haematologica. 2013 Aug;98(8):1273-81
pubmed: 23445874
Br J Haematol. 2014 Jul;166(1):23-33
pubmed: 24749666
J Clin Oncol. 2001 Jul 15;19(14):3406-14
pubmed: 11454889
Blood. 2000 Jul 1;96(1):24-33
pubmed: 10891426
Biol Blood Marrow Transplant. 2006 Apr;12(4):438-53
pubmed: 16545728
J Clin Oncol. 2014 Sep 20;32(27):3021-32
pubmed: 25092781
Br J Haematol. 2016 Aug;174(4):600-9
pubmed: 27072379
Br J Haematol. 2012 Nov;159(3):259-76
pubmed: 22966788
Haematologica. 2017 May;102(5):865-873
pubmed: 28126965
Blood. 2011 Dec 15;118(25):6683-90
pubmed: 22010101
Am J Hematol. 2020 Jan;95(1):28-37
pubmed: 31625177
Br J Haematol. 2000 Mar;108(3):531-43
pubmed: 10759711
Blood. 2014 Jun 19;123(25):3895-905
pubmed: 24753538
Br J Haematol. 2014 Feb;164(3):396-408
pubmed: 24422724
Leukemia. 2012 Dec;26(12):2455-61
pubmed: 22555150
Blood. 1992 May 15;79(10):2578-82
pubmed: 1586710
Lancet Oncol. 2017 Aug;18(8):1126-1136
pubmed: 28705454
J Clin Oncol. 1991 Oct;9(10):1880-8
pubmed: 1919638
J Clin Oncol. 2012 May 10;30(14):1663-9
pubmed: 22412151
Bone Marrow Transplant. 2020 Jan;55(1):12-24
pubmed: 30833742
Haematologica. 2016 Apr;101(4):e153-6
pubmed: 26768688
J Clin Oncol. 2008 Sep 10;26(26):4326-32
pubmed: 18779619
Blood. 2011 Jan 20;117(3):764-71
pubmed: 20889923
Lancet Haematol. 2020 Feb;7(2):e134-e145
pubmed: 31704264
Biol Blood Marrow Transplant. 2018 Sep;24(9):1848-1855
pubmed: 29772352
Leukemia. 2009 Feb;23(2):262-70
pubmed: 19020547
Hematol Oncol Stem Cell Ther. 2011;4(1):17-29
pubmed: 21460603
Leukemia. 2020 Feb;34(2):613-624
pubmed: 31578451
Biol Blood Marrow Transplant. 2015 Jul;21(7):1266-72
pubmed: 25765555
Blood. 2007 Aug 15;110(4):1112-5
pubmed: 17473063
Blood. 2018 Jul 26;132(4):405-412
pubmed: 29789356
Blood. 2017 Jun 22;129(25):3322-3331
pubmed: 28408462
Lancet Oncol. 2014 Jul;15(8):809-18
pubmed: 24924991
Blood. 2008 Jun 15;111(12):5477-85
pubmed: 18388178
Blood. 2009 Mar 26;113(13):3119-29
pubmed: 18945967
Bone Marrow Transplant. 2021 Mar;56(3):586-595
pubmed: 32968215
Am J Hematol. 2018 Oct;93(10):1236-1244
pubmed: 30058714
Am J Hematol. 2020 Jul;95(7):809-816
pubmed: 32267023
Ann N Y Acad Sci. 2007 Jun;1106:279-89
pubmed: 17442774
Blood. 2007 Apr 1;109(7):2791-3
pubmed: 17119111
Cancer Cell. 2012 Nov 13;22(5):683-97
pubmed: 23153540
Blood. 2012 Jul 12;120(2):468-72
pubmed: 22517895
Blood. 2000 Mar 1;95(5):1572-9
pubmed: 10688810
Blood Adv. 2019 Nov 12;3(21):3393-3405
pubmed: 31714961
Blood Adv. 2020 Aug 25;4(16):3913-3925
pubmed: 32813874
Blood. 2007 Jun 1;109(11):4641-7
pubmed: 17299091
Haematologica. 2020 Jan;105(1):47-58
pubmed: 31537691
Blood. 2010 Oct 14;116(15):2644-50
pubmed: 20592248
J Clin Oncol. 2013 Sep 20;31(27):3389-96
pubmed: 23940220
J Clin Oncol. 2018 Apr 20;36(12):1240-1249
pubmed: 29498923
Blood. 2007 Jul 1;110(1):433-40
pubmed: 17371948
Blood. 2002 Aug 15;100(4):1192-200
pubmed: 12149197
Biol Blood Marrow Transplant. 2017 Mar;23(3):467-474
pubmed: 27916512
Bone Marrow Transplant. 2021 Jul;56(7):1614-1624
pubmed: 33594278
J Clin Oncol. 2017 Aug 10;35(23):2674-2682
pubmed: 28644774
Blood. 2006 Dec 1;108(12):3654-61
pubmed: 16912228
Blood. 2010 Apr 22;115(16):3206-14
pubmed: 20154213
Bone Marrow Transplant. 2020 Oct;55(10):1996-2007
pubmed: 32203268
Immunol Lett. 2013 Sep-Oct;155(1-2):21-3
pubmed: 24091162
Lancet. 2001 Oct 13;358(9289):1239-41
pubmed: 11675066
Pediatr Blood Cancer. 2016 Apr;63(4):701-5
pubmed: 26670954
Br J Haematol. 2014 Jun;165(5):688-98
pubmed: 24588540
Bone Marrow Transplant. 2019 May;54(5):737-745
pubmed: 30258130
J Clin Oncol. 2019 Apr 1;37(10):780-789
pubmed: 30742559
J Clin Oncol. 2021 Jun 10;39(17):1865-1877
pubmed: 33449816
Pediatr Blood Cancer. 2014 Apr;61(4):712-6
pubmed: 24376191
Blood Cancer J. 2020 Jul 24;10(7):77
pubmed: 32709851
Br J Haematol. 2018 Mar;180(5):680-693
pubmed: 29359790
Blood. 1998 Dec 1;92(11):4072-9
pubmed: 9834212
J Clin Oncol. 2016 Mar 1;34(7):747-55
pubmed: 26786921
J Clin Oncol. 2013 Sep 20;31(27):3397-402
pubmed: 23940221
Blood. 2012 Aug 23;120(8):1581-8
pubmed: 22649108
Front Pharmacol. 2015 May 05;6:95
pubmed: 25999859
Blood. 2021 Feb 18;137(7):983-993
pubmed: 33206937
Blood. 2018 Oct 18;132(16):1703-1713
pubmed: 30190321
Bone Marrow Transplant. 2021 Jun;56(6):1426-1432
pubmed: 33469191
Blood. 2012 Dec 20;120(26):5173-80
pubmed: 23074282
Blood. 2017 Jul 20;130(3):285-296
pubmed: 28539325
Bone Marrow Transplant. 2014 Mar;49(3):382-8
pubmed: 24317131
J Clin Oncol. 2012 Oct 10;30(29):3625-32
pubmed: 22965955
Blood. 2013 Apr 4;121(14):2734-8
pubmed: 23377436
Pediatr Blood Cancer. 2019 Jan;66(1):e27481
pubmed: 30318867
Bone Marrow Transplant. 2020 May;55(5):929-938
pubmed: 31740766
Blood. 2003 May 15;101(10):3835-9
pubmed: 12732501
J Clin Oncol. 2015 Apr 10;33(11):1275-84
pubmed: 25605857
Blood. 2015 Jun 25;125(26):3996-4009
pubmed: 25999452
JAMA. 2021 Mar 2;325(9):833-842
pubmed: 33651090
Expert Rev Clin Immunol. 2016;12(3):343-58
pubmed: 26588325
J Clin Oncol. 2010 Jun 1;28(16):2674-81
pubmed: 20439644
Biol Blood Marrow Transplant. 2018 Oct;24(10):2040-2046
pubmed: 29933069
Bone Marrow Transplant. 2017 Jun;52(6):825-831
pubmed: 28218757
Blood. 2001 Sep 15;98(6):1746-51
pubmed: 11535507
J Clin Oncol. 2019 Feb 10;37(5):367-374
pubmed: 30523748
Lancet Oncol. 2008 Sep;9(9):873-83
pubmed: 18760243
Leukemia. 2016 Jul;30(7):1456-64
pubmed: 27012865
Hematology Am Soc Hematol Educ Program. 2020 Dec 4;2020(1):501-507
pubmed: 33275706
Front Immunol. 2020 May 12;11:699
pubmed: 32477328
Science. 2002 Mar 15;295(5562):2097-100
pubmed: 11896281
Blood. 2003 Dec 15;102(13):4290-7
pubmed: 12920027
Blood. 2001 Jan 1;97(1):56-62
pubmed: 11133742
Leukemia. 2021 Jul;35(7):1843-1863
pubmed: 33953290
Blood. 2003 Oct 1;102(7):2387-94
pubmed: 12816873
J Clin Oncol. 2011 Mar 20;29(9):1190-7
pubmed: 21282535
J Clin Oncol. 1999 Jun;17(6):1838-46
pubmed: 10561223
Br J Haematol. 2015 Nov;171(4):566-73
pubmed: 26223157
J Clin Oncol. 2000 Jan;18(2):340-7
pubmed: 10637248
Blood. 2014 Mar 27;123(13):2017-25
pubmed: 24497539
Front Immunol. 2021 Mar 12;12:630429
pubmed: 33790903
J Clin Oncol. 2021 Feb 1;39(4):295-307
pubmed: 33332189
Bone Marrow Transplant. 2020 Aug;55(8):1540-1551
pubmed: 32203263
Biol Blood Marrow Transplant. 2013 Feb;19(2):255-9
pubmed: 23041605
Blood. 2011 Aug 25;118(8):2077-84
pubmed: 21719599
Br J Haematol. 2002 Aug;118(2):378-84
pubmed: 12139721
J Clin Oncol. 2012 Mar 1;30(7):735-41
pubmed: 22291086
Pediatr Blood Cancer. 2018 Apr;65(4):
pubmed: 29230958
Blood. 2013 Apr 25;121(17):3469-72
pubmed: 23407549
Nat Genet. 2017 Mar;49(3):451-456
pubmed: 28112737
Nat Genet. 2015 Sep;47(9):1020-1029
pubmed: 26214592
Leukemia. 2019 Apr;33(4):884-892
pubmed: 30267011
Biol Blood Marrow Transplant. 2003 Nov;9(11):706-13
pubmed: 14652854
Br J Haematol. 2014 May;165(3):392-401
pubmed: 24479958
Genes Chromosomes Cancer. 2006 Aug;45(8):731-9
pubmed: 16646086
Haematologica. 2021 Feb 01;106(2):630-634
pubmed: 32381579
J Clin Oncol. 2005 Nov 1;23(31):7942-50
pubmed: 16258094
J Clin Oncol. 2010 Jun 1;28(16):2682-9
pubmed: 20439630
Br J Haematol. 2003 Jul;122(2):217-25
pubmed: 12846889
Blood. 2014 Oct 23;124(17):2744-7
pubmed: 25115891
Br J Haematol. 2014 Jul;166(2):254-259
pubmed: 24661089
Genes Chromosomes Cancer. 2013 Jul;52(7):683-93
pubmed: 23630019
Blood. 2019 Aug 22;134(8):713-716
pubmed: 31311816
Blood. 2017 Aug 3;130(5):677-685
pubmed: 28588018
J Clin Oncol. 2016 Dec 20;34(36):4381-4389
pubmed: 27998223
N Engl J Med. 2012 Apr 12;366(15):1371-81
pubmed: 22494120
Leukemia. 2017 Dec;31(12):2807-2814
pubmed: 28443606
Leukemia. 2015 Aug;29(8):1648-55
pubmed: 25748682
Pediatr Blood Cancer. 2014 May;61(5):925-7
pubmed: 24302531
Pediatr Transplant. 2020 Jun;24(4):e13672
pubmed: 32068340
J Clin Oncol. 2021 May 28;:JCO2003048
pubmed: 34048275
Leukemia. 2017 Mar;31(3):565-572
pubmed: 27694926
Expert Rev Anticancer Ther. 2021 Jan;21(1):45-52
pubmed: 33111585
Blood. 2015 Aug 20;126(8):983-92
pubmed: 26056165
Blood Adv. 2019 Nov 26;3(22):3750-3758
pubmed: 31770440
Blood. 1998 Oct 1;92(7):2322-33
pubmed: 9746770
Blood. 2011 Jul 14;118(2):223-30
pubmed: 21613256
Blood. 2013 Jul 11;122(2):170-8
pubmed: 23673857
Biol Blood Marrow Transplant. 2015 Dec;21(12):2141-2147
pubmed: 26271192
Leukemia. 2017 Apr;31(4):974-977
pubmed: 27890935
Blood. 2012 Oct 4;120(14):2807-16
pubmed: 22896001
Blood. 2015 Apr 9;125(15):2349-58
pubmed: 25612623
Biol Blood Marrow Transplant. 2017 Jan;23(1):87-95
pubmed: 27742575
Ann Hematol. 2015 Feb;94(2):297-306
pubmed: 25231927
Lancet. 2010 Dec 11;376(9757):2009-17
pubmed: 21131038
Pediatr Blood Cancer. 2015 Jun;62(6):1048-54
pubmed: 25662999
Br J Haematol. 2002 Aug;118(2):365-77
pubmed: 12139720
J Clin Oncol. 2008 Dec 10;26(35):5797-801
pubmed: 18955460
Pediatr Blood Cancer. 2016 Nov;63(11):1943-8
pubmed: 27437864
Blood. 1987 Nov;70(5):1382-8
pubmed: 3311203
Blood. 2014 Jul 31;124(5):822-6
pubmed: 24869942
Blood. 2014 Mar 6;123(10):1615-20
pubmed: 24435046
J Clin Oncol. 2017 Sep 10;35(26):3002-3009
pubmed: 28644773
Blood. 2009 Sep 17;114(12):2489-96
pubmed: 19528532
N Engl J Med. 2011 Nov 3;365(18):1673-83
pubmed: 22047558
JAMA. 2021 Mar 2;325(9):843-854
pubmed: 33651091
Leukemia. 2004 Mar;18(3):499-504
pubmed: 14981525
Blood. 2013 Oct 10;122(15):2704-13
pubmed: 23974201
Biol Blood Marrow Transplant. 2018 Aug;24(8):1651-1656
pubmed: 29753157
Blood. 2019 May 23;133(21):2291-2304
pubmed: 30796021
Blood. 2018 Oct 11;132(15):1604-1613
pubmed: 30108064
Br J Haematol. 2015 Jun;169(5):726-36
pubmed: 25818248
Bone Marrow Transplant. 2021 Jul;56(7):1651-1664
pubmed: 33623153
Clin Cancer Res. 2016 Apr 15;22(8):1951-7
pubmed: 26644412
Haematologica. 2021 Jul 01;106(7):1839-1845
pubmed: 32554562
Lancet. 2007 Jul 21;370(9583):240-250
pubmed: 17658395
Blood. 2010 Nov 11;116(19):4007-15
pubmed: 20671124
Blood. 2018 Oct 11;132(15):1584-1592
pubmed: 30150206
Expert Opin Biol Ther. 2020 Oct;20(10):1223-1236
pubmed: 32529854
Blood. 2014 Jan 2;123(1):133-40
pubmed: 24141369
Lancet Oncol. 2010 Jun;11(6):543-52
pubmed: 20451454
Pediatr Blood Cancer. 2015 Oct;62(10):1844-50
pubmed: 26053959
Biol Blood Marrow Transplant. 2008 Jun;14(6):641-50
pubmed: 18489989
N Engl J Med. 2014 Jul 24;371(4):339-48
pubmed: 25054717
Biol Blood Marrow Transplant. 2016 Nov;22(11):2056-2064
pubmed: 27519279
Lancet Oncol. 2011 Dec;12(13):1214-21
pubmed: 21982422
Nat Genet. 2019 Apr;51(4):694-704
pubmed: 30926971
J Clin Oncol. 2021 May 20;39(15):1650-1659
pubmed: 33764809
Bone Marrow Transplant. 2003 Sep;32(6):543-8
pubmed: 12953124
Transplant Cell Ther. 2021 May;27(5):424.e1-424.e9
pubmed: 33965182
J Clin Oncol. 2020 Jun 10;38(17):1938-1950
pubmed: 32286905
Pediatr Blood Cancer. 2013 Dec;60(12):2073-8
pubmed: 24039149
Bone Marrow Transplant. 1995 Jul;16(1):133-7
pubmed: 7581113
Biol Blood Marrow Transplant. 2015 Apr;21(4):653-60
pubmed: 25540937
Leukemia. 2018 Sep;32(9):1970-1983
pubmed: 29483708
J Clin Oncol. 2019 Apr 1;37(10):770-779
pubmed: 30657737
Bone Marrow Transplant. 2015 Feb;50(2):181-8
pubmed: 25387094
Biol Blood Marrow Transplant. 2019 Apr;25(4):734-742
pubmed: 30385256
Bone Marrow Transplant. 2020 Oct;55(10):1918-1927
pubmed: 31996791
Blood. 2009 Jun 25;113(26):6558-66
pubmed: 19304957
N Engl J Med. 2009 Jan 29;360(5):470-80
pubmed: 19129520
Br J Haematol. 2020 May;189(4):745-750
pubmed: 32012224
J Clin Invest. 2003 Jul;112(1):101-8
pubmed: 12840064
Blood. 2016 Jun 30;127(26):3450-7
pubmed: 27099151
N Engl J Med. 1987 Dec 24;317(26):1618-24
pubmed: 3317056
Blood. 2015 May 28;125(22):3501-8
pubmed: 25862561
Haematologica. 2014 May;99(5):865-72
pubmed: 24441146
J Clin Oncol. 2009 Jan 20;27(3):377-84
pubmed: 19064980
Oncoimmunology. 2016 Sep 27;6(2):e1216291
pubmed: 28344861
Leukemia. 2021 May 25;:
pubmed: 34035409
Blood. 2018 Dec 13;132(24):2594-2607
pubmed: 30348653
J Clin Oncol. 2004 May 1;22(9):1696-705
pubmed: 15117992
N Engl J Med. 2016 Sep 8;375(10):944-53
pubmed: 27602666
Curr Hematol Malig Rep. 2017 Feb;12(1):68-78
pubmed: 28116633
Biol Blood Marrow Transplant. 2015 Apr;21(4):729-37
pubmed: 25644958
Biol Blood Marrow Transplant. 2012 Feb;18(2):324-9
pubmed: 22079471
N Engl J Med. 1994 Nov 10;331(19):1253-8
pubmed: 7935682
Biol Blood Marrow Transplant. 2011 Sep;17(9):1404-9
pubmed: 21324374
Lancet. 2007 Jun 9;369(9577):1947-54
pubmed: 17560447
Lancet Oncol. 2009 May;10(5):489-500
pubmed: 19345145
Leukemia. 2018 Oct;32(10):2167-2177
pubmed: 29550834
Haematologica. 2019 Jun;104(6):e244-e247
pubmed: 30765470
Oncotarget. 2017 Sep 14;8(57):96460-96461
pubmed: 29228536
J Clin Oncol. 2017 Mar 20;35(9):975-983
pubmed: 28297628
Blood. 2021 Mar 25;137(12):1582-1590
pubmed: 33067614
J Clin Oncol. 2015 Apr 10;33(11):1265-74
pubmed: 25753432
Leukemia. 2020 Jan;34(1):293-295
pubmed: 31435023
Blood. 1994 May 1;83(9):2723-30
pubmed: 8167351
Hematology Am Soc Hematol Educ Program. 2020 Dec 4;2020(1):494-500
pubmed: 33275678
Haematologica. 2015 Mar;100(3):e99-101
pubmed: 25480496
Bone Marrow Transplant. 1997 Nov;20(9):773-7
pubmed: 9384480
J Leukoc Biol. 2013 Dec;94(6):1141-57
pubmed: 24096380
N Engl J Med. 2014 Oct 30;371(18):1685-94
pubmed: 25354103
Leukemia. 2002 Nov;16(11):2228-37
pubmed: 12399966