Catalase Predicts In-Hospital Mortality after Out-of-Hospital Cardiac Arrest.
MRM
catalase
out-of-hospital cardiac arrest
survival
targeted proteomics
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
30 Aug 2021
30 Aug 2021
Historique:
received:
02
08
2021
revised:
25
08
2021
accepted:
27
08
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
11
9
2021
Statut:
epublish
Résumé
The generation of harmful reactive oxygen species (ROS), including hydrogen peroxide, in out-of-hospital cardiac arrest (OHCA) survivors causes systemic ischemia/reperfusion injury that may lead to multiple organ dysfunction and mortality. We hypothesized that the antioxidant enzyme catalase may attenuate these pathophysiological processes after cardiac arrest. Therefore, we aimed to analyze the predictive value of catalase levels for mortality in OHCA survivors. In a prospective, single-center study, catalase levels were determined in OHCA survivors 48 h after the return of spontaneous circulation. Thirty-day mortality was defined as the study end point. A total of 96 OHCA survivors were enrolled, of whom 26% (
Identifiants
pubmed: 34501367
pii: jcm10173906
doi: 10.3390/jcm10173906
pmc: PMC8432041
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Oesterreichische Nationalbank
ID : 15959
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