GLP-1 Receptor Agonists in Diabetic Kidney Disease: From Physiology to Clinical Outcomes.
GLP-1 receptor agonists
diabetic kidney disease
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
31 Aug 2021
31 Aug 2021
Historique:
received:
15
07
2021
revised:
25
08
2021
accepted:
31
08
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
11
9
2021
Statut:
epublish
Résumé
Diabetic kidney disease (DKD) is one of the most common complications in type 2 diabetes mellitus (T2D) and a major cause of morbidity and mortality in diabetes. Despite the widespread use of nephroprotective treatment of T2D, the incidence of DKD is increasing, and it is expected to become the fifth cause of death worldwide within 20 years. Previous studies have demonstrated that GLP-1 receptor agonists (GLP-1 RA) have improved macrovascular and microvascular outcomes independent of glycemic differences, including DKD. GLP-1Ras' improvement on kidney physiology is mediated by natriuresis, reduction in hyperfiltration and renin-angiotensin-aldosterone system (RAAS) activity and anti-inflammatory properties. These findings translate into improved clinical outcomes such as an enhanced urine albumin-to-creatinine ratio (UACR) and a reduction in renal impairment and the need for renal replacement therapies (RRT). In this article, we review the role of GLP-1RAs on the mechanisms and effect in DKD and their clinical efficacy.
Identifiants
pubmed: 34501404
pii: jcm10173955
doi: 10.3390/jcm10173955
pmc: PMC8432108
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Obes Res Clin Pract. 2019 Jul - Aug;13(4):385-390
pubmed: 30952571
Kidney Int. 2008 Jan;73(1):19-33
pubmed: 17928825
J Endocrinol. 2014 Mar 07;221(1):T1-16
pubmed: 24323912
PLoS One. 2018 Mar 28;13(3):e0193473
pubmed: 29590132
Mol Med Rep. 2014 Nov;10(5):2587-94
pubmed: 25215431
Methods Mol Biol. 2020;2067:3-7
pubmed: 31701441
J Pharmacol Exp Ther. 2019 Jun;369(3):375-388
pubmed: 30910920
J Am Soc Nephrol. 2006 Jun;17(6):1695-702
pubmed: 16641153
J Am Heart Assoc. 2017 Mar 6;6(3):
pubmed: 28264861
Am J Physiol Renal Physiol. 2009 Dec;297(6):F1647-55
pubmed: 19776173
J Hypertens. 2005 Nov;23(11):1931-7
pubmed: 16208129
Gut. 2016 Apr;65(4):702-11
pubmed: 26786687
Kidney Int. 2000 Jul;58(1):293-301
pubmed: 10886574
Biomed Pharmacother. 2019 Dec;120:109537
pubmed: 31605951
Curr Opin Nephrol Hypertens. 2006 Sep;15(5):481-6
pubmed: 16914959
Diabetes Care. 2004 Nov;27(11):2628-35
pubmed: 15504997
Lancet Diabetes Endocrinol. 2019 Jul;7(7):515-527
pubmed: 31189517
Diabetes Res Clin Pract. 2019 Jul;153:14-22
pubmed: 31078666
Circulation. 2019 Apr 23;139(17):2022-2031
pubmed: 30786725
BMC Res Notes. 2014 Jul 02;7:415
pubmed: 24990184
Lancet. 2018 Oct 27;392(10157):1519-1529
pubmed: 30291013
J Clin Endocrinol Metab. 2013 Apr;98(4):E664-71
pubmed: 23463656
Diabetes Obes Metab. 2016 Jun;18(6):581-9
pubmed: 26910107
Lancet. 1998 Sep 12;352(9131):837-53
pubmed: 9742976
Am J Physiol Renal Physiol. 2015 Apr 15;308(8):F867-77
pubmed: 25656368
Am J Physiol Renal Physiol. 2016 Jan 15;310(2):F123-7
pubmed: 26447224
N Engl J Med. 2019 Aug 29;381(9):841-851
pubmed: 31185157
Lancet Diabetes Endocrinol. 2016 Jun;4(6):525-36
pubmed: 26876794
Nat Rev Nephrol. 2016 Feb;12(2):73-81
pubmed: 26553517
N Engl J Med. 2016 Nov 10;375(19):1834-1844
pubmed: 27633186
Ann Intern Med. 2006 Jan 3;144(1):21-8
pubmed: 16389251
Kidney Int. 2015 Dec;88(6):1230-1232
pubmed: 26649662
Am J Physiol Endocrinol Metab. 2015 Apr 15;308(8):E641-9
pubmed: 25670826
Nat Rev Endocrinol. 2016 Oct;12(10):566-92
pubmed: 27339889
Kidney Int. 2012 Dec;82(12):1313-20
pubmed: 22874843
Kidney Int. 2014 Mar;85(3):579-89
pubmed: 24152968
Clin Ther. 2015 Jan 1;37(1):225-241.e8
pubmed: 25554560
Am J Physiol Renal Physiol. 2015 Jul 1;309(1):F2-23
pubmed: 25925260
Diabetes Care. 2020 Jan;43(Suppl 1):S98-S110
pubmed: 31862752
Can J Diabetes. 2014 Oct;38(5):364-71
pubmed: 25284699
J Clin Med. 2020 Mar 30;9(4):
pubmed: 32235471
Eur J Pharmacol. 2002 Jan 11;434(3):163-7
pubmed: 11779579
J Diabetes. 2019 Aug;11(8):656-664
pubmed: 30575282
Cardiovasc Diabetol. 2015 Mar 07;14:29
pubmed: 25888997
Am J Physiol. 1998 Jan;274(1):F111-9
pubmed: 9458830
Am J Physiol Endocrinol Metab. 2004 Dec;287(6):E1209-15
pubmed: 15353407
Diabetes Obes Metab. 2009 Dec;11(12):1163-72
pubmed: 19930006
Int J Obes (Lond). 2014 Jun;38(6):784-93
pubmed: 23999198
Diabetes Obes Metab. 2016 Mar;18(3):203-16
pubmed: 26489970
Am J Kidney Dis. 2008 Jul;52(1):39-48
pubmed: 18440684
Lancet Diabetes Endocrinol. 2020 Nov;8(11):880-893
pubmed: 32971040
BMC Nephrol. 2013 Feb 22;14:46
pubmed: 23433046
Clin J Am Soc Nephrol. 2020 Apr 7;15(4):465-473
pubmed: 32132141
Am J Physiol Renal Physiol. 2013 Jan 15;304(2):F137-44
pubmed: 23019232
N Engl J Med. 2017 Aug 31;377(9):839-848
pubmed: 28854085
Circulation. 2018 Dec 18;138(25):2908-2918
pubmed: 30566006
J Clin Endocrinol Metab. 1986 Aug;63(2):492-8
pubmed: 3522621
Medicine (Baltimore). 2021 Feb 26;100(8):e24655
pubmed: 33663074
Lancet Diabetes Endocrinol. 2018 Aug;6(8):605-617
pubmed: 29910024
Nat Rev Endocrinol. 2012 Dec;8(12):728-42
pubmed: 22945360
Annu Rev Physiol. 2014;76:535-59
pubmed: 24245943
Diabet Med. 2015 Mar;32(3):343-52
pubmed: 25251901
Clin Pharmacokinet. 2015 Jan;54(1):1-21
pubmed: 25331711
N Engl J Med. 2014 Apr 17;370(16):1514-23
pubmed: 24738668
J Clin Endocrinol Metab. 2008 Nov;93(11 Suppl 1):S57-63
pubmed: 18987271
Lancet. 2019 Jul 13;394(10193):131-138
pubmed: 31189509
Diabetes Care. 2010 Aug;33(8):1734-7
pubmed: 20424219
J Clin Endocrinol Metab. 2011 Mar;96(3):737-45
pubmed: 21252240
Lancet Diabetes Endocrinol. 2017 Aug;5(8):569-571
pubmed: 28666776
N Engl J Med. 2015 Dec 3;373(23):2247-57
pubmed: 26630143
N Engl J Med. 2017 Sep 28;377(13):1228-1239
pubmed: 28910237
Semin Nephrol. 2003 Mar;23(2):194-9
pubmed: 12704579
J Am Soc Nephrol. 2008 Feb;19(2):207-12
pubmed: 18216308
JAMA. 2015 Sep 8;314(10):1052-62
pubmed: 26348754
Annu Rev Physiol. 2008;70:379-403
pubmed: 17988205
Cell Biol Int. 2019 Aug;43(8):940-953
pubmed: 31136032
Diabetes Obes Metab. 2016 Feb;18(2):178-85
pubmed: 26636423
Lancet Diabetes Endocrinol. 2015 May;3(5):367-81
pubmed: 25943756
Am J Physiol Renal Physiol. 2004 Jan;286(1):F8-15
pubmed: 14656757
J Diabetes Complications. 2015 Jul;29(5):670-4
pubmed: 25935863
Diabetes Obes Metab. 2016 Mar;18(3):224-35
pubmed: 26500045
Regul Pept. 2005 Feb 15;125(1-3):173-7
pubmed: 15582729
Nat Rev Nephrol. 2014 Feb;10(2):88-103
pubmed: 24375052
Lancet Diabetes Endocrinol. 2016 Jun;4(6):537-47
pubmed: 27156051
N Engl J Med. 2021 Mar 18;384(11):989
pubmed: 33567185
J Clin Endocrinol Metab. 2004 Jun;89(6):3055-61
pubmed: 15181098
Diabetes Res Clin Pract. 2015 Oct;110(1):26-37
pubmed: 26358202
J Nephrol. 2020 Oct;33(5):1001-1008
pubmed: 32328901
J Am Soc Nephrol. 2017 Apr;28(4):1023-1039
pubmed: 28143897