Histone Deacetylase 3 Regulates Adipocyte Phenotype at Early Stages of Differentiation.
HDAC3
adipocytes
differentiation
epigenetics
inflammation
metabolism
obesity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Aug 2021
27 Aug 2021
Historique:
received:
02
08
2021
accepted:
23
08
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Obesity is a condition characterized by uncontrolled expansion of adipose tissue mass resulting in pathological weight gain. Histone deacetylases (HDACs) have emerged as crucial players in epigenetic regulation of adipocyte metabolism. Previously, we demonstrated that selective inhibition of class I HDACs improves white adipocyte functionality and promotes the browning phenotype of murine mesenchymal stem cells (MSCs) C3H/10T1/2 differentiated to adipocytes. These effects were also observed in
Identifiants
pubmed: 34502211
pii: ijms22179300
doi: 10.3390/ijms22179300
pmc: PMC8430751
pii:
doi:
Substances chimiques
Histone Deacetylases
EC 3.5.1.98
histone deacetylase 3
EC 3.5.1.98
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : FP7 People: Marie-Curie Actions
ID : 606806
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : Progetto eccellenza 2018-2022
Organisme : Fondazione Cariplo
ID : 2015-0641
Organisme : European Foundation for the Study of Diabetes
ID : European Research Programme on New Targets for Type 2 Diabetes 2019
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