In Situ Hydroxyapatite Synthesis Enhances Biocompatibility of PVA/HA Hydrogels.
biological evaluation
bone tissue engineering
cell viability
hyaluronic acid
hydrogel
hydroxyapatite
in situ synthesis
polyvinyl alcohol
scaffold
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Aug 2021
28 Aug 2021
Historique:
received:
12
07
2021
revised:
20
08
2021
accepted:
25
08
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Bone tissue engineering tries to simulate natural behavior of hard tissues. This study aimed to produce scaffolds based on polyvinyl alcohol (PVA) and hyaluronic acid (HA) with hydroxyapatite (HAp) incorporated in two different ways, by in situ synthesis and physical mixing of pre-prepared HAp. In situ synthesis resulted in calcium deficient form of HAp with lower crystallinity. The proliferation of human osteoblast-like cells MG-63 proved to be better in the scaffolds with in situ synthesized HAp compared to those with physically mixed pre-prepared HAp. For scaffolds with PVA/HA/HAp ratio 3:1:2, there was significantly higher initial adhesion (
Identifiants
pubmed: 34502243
pii: ijms22179335
doi: 10.3390/ijms22179335
pmc: PMC8431644
pii:
doi:
Substances chimiques
Biocompatible Materials
0
Hydrogels
0
Polyvinyl Alcohol
9002-89-5
Hyaluronic Acid
9004-61-9
Durapatite
91D9GV0Z28
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerstvo Školství, Mládeže a Tělovýchovy
ID : SVV 2020-260 540
Organisme : Ministerstvo Školství, Mládeže a Tělovýchovy
ID : CZ.02.1.01/0.0/0.0/16_019/0000787
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