Oral Squamous Cell Carcinoma Contributes to Differentiation of Monocyte-Derived Tumor-Associated Macrophages via PAI-1 and IL-8 Production.
Carcinoma, Squamous Cell
/ pathology
Cell Differentiation
/ genetics
Cell Line, Tumor
Head and Neck Neoplasms
/ pathology
Humans
Immunohistochemistry
Interleukin-8
/ metabolism
Leukocytes, Mononuclear
/ cytology
Macrophages
/ metabolism
Plasminogen Activator Inhibitor 1
/ metabolism
Squamous Cell Carcinoma of Head and Neck
/ metabolism
Tumor Microenvironment
Tumor-Associated Macrophages
/ metabolism
CD206
interleukin-8
oral squamous cell carcinoma
plasminogen activator inhibitor–1
tumor-associated macrophage
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Aug 2021
31 Aug 2021
Historique:
received:
23
07
2021
revised:
27
08
2021
accepted:
30
08
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
3
11
2021
Statut:
epublish
Résumé
Tumor-associated macrophages (TAMs) promote cancer cell proliferation and metastasis, as well as anti-tumor immune suppression. Recent studies have shown that tumors enhance the recruitment and differentiation of TAMs, but the detailed mechanisms have not been clarified. We thus examined the influence of cancer cells on the differentiation of monocytes to TAM subsets, including CD163
Identifiants
pubmed: 34502382
pii: ijms22179475
doi: 10.3390/ijms22179475
pmc: PMC8430735
pii:
doi:
Substances chimiques
CXCL8 protein, human
0
Interleukin-8
0
Plasminogen Activator Inhibitor 1
0
SERPINE1 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : 20K23086
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : 21K17107
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : 21H03141
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