The Serum Metabolome of Moderate and Severe COVID-19 Patients Reflects Possible Liver Alterations Involving Carbon and Nitrogen Metabolism.
Amino Acids
/ metabolism
Biomarkers
/ blood
COVID-19
/ blood
Carbon
/ metabolism
Cytokines
/ blood
Discriminant Analysis
Humans
Least-Squares Analysis
Liver
/ metabolism
Metabolic Networks and Pathways
/ genetics
Metabolome
Metabolomics
/ methods
Nitrogen
/ metabolism
SARS-CoV-2
/ isolation & purification
Severity of Illness Index
COVID-19
SARS-CoV-2
coronavirus
lactic acid
mass spectrometry
metabolomics
serum cytokines
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
02 Sep 2021
02 Sep 2021
Historique:
received:
15
07
2021
revised:
17
08
2021
accepted:
30
08
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
18
9
2021
Statut:
epublish
Résumé
COVID-19 is a global threat that has spread since the end of 2019, causing severe clinical sequelae and deaths, in the context of a world pandemic. The infection of the highly pathogenetic and infectious SARS-CoV-2 coronavirus has been proven to exert systemic effects impacting the metabolism. Yet, the metabolic pathways involved in the pathophysiology and progression of COVID-19 are still unclear. Here, we present the results of a mass spectrometry-based targeted metabolomic analysis on a cohort of 52 hospitalized COVID-19 patients, classified according to disease severity as mild, moderate, and severe. Our analysis defines a clear signature of COVID-19 that includes increased serum levels of lactic acid in all the forms of the disease. Pathway analysis revealed dysregulation of energy production and amino acid metabolism. Globally, the variations found in the serum metabolome of COVID-19 patients may reflect a more complex systemic perturbation induced by SARS-CoV-2, possibly affecting carbon and nitrogen liver metabolism.
Identifiants
pubmed: 34502454
pii: ijms22179548
doi: 10.3390/ijms22179548
pmc: PMC8431319
pii:
doi:
Substances chimiques
Amino Acids
0
Biomarkers
0
Cytokines
0
Carbon
7440-44-0
Nitrogen
N762921K75
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Regione Campania
ID : D64I200003800
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