Host-Microbiota Interactions in Liver Inflammation and Cancer.
alcoholic liver disease
cirrhosis
gut-liver axis
inflammation
innate immunity
metabolism
microbiome
obesity
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
27 Aug 2021
27 Aug 2021
Historique:
received:
01
08
2021
revised:
20
08
2021
accepted:
24
08
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
11
9
2021
Statut:
epublish
Résumé
Hepatocellular carcinoma (HCC) is a classical inflammation-promoted cancer that occurs in a setting of liver diseases, including nonalcoholic fatty liver disease (NAFLD) or alcoholic liver disease (ALD). These pathologies share key characteristics, notably intestinal dysbiosis, increased intestinal permeability and an imbalance in bile acids, choline, fatty acids and ethanol metabolites. Translocation of microbial- and danger-associated molecular patterns (MAMPs and DAMPs) from the gut to the liver elicits profound chronic inflammation, leading to severe hepatic injury and eventually HCC progression. In this review, we first describe how the gut and the liver communicate and discuss mechanisms by which the intestinal microbiota elicit hepatic inflammation and HCC. We focus on the role of microbial products, e.g., MAMPs, host inflammatory effectors and host-microbiome-derived metabolites in tumor-promoting mechanisms, including cell death and senescence. Last, we explore the potential of harnessing the microbiota to treat liver diseases and HCC.
Identifiants
pubmed: 34503151
pii: cancers13174342
doi: 10.3390/cancers13174342
pmc: PMC8430654
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Fondation ARC pour la Recherche sur le Cancer
ID : LEADERS DE DEMAIN EN ONCOLOGIE
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