Niraparib Suppresses Cholangiocarcinoma Tumor Growth by Inducing Oxidative and Replication Stress.
PAPR inhibitors
cholangiocarcinoma
oxidative stress
patient derived xenograft
replication fork stalling
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
31 Aug 2021
31 Aug 2021
Historique:
received:
27
05
2021
revised:
22
07
2021
accepted:
27
08
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
11
9
2021
Statut:
epublish
Résumé
Cholangiocarcinoma (CCA) is the second most common hepatobiliary cancer, an aggressive malignancy with limited therapeutic options. PARP (poly (ADP-ribose) polymerase) 1 and 2 are important for deoxyribonucleotide acid (DNA) repair and maintenance of genomic stability. PARP inhibitors (PARPi) such as niraparib have been approved for different malignancies with genomic alteration in germline
Identifiants
pubmed: 34503215
pii: cancers13174405
doi: 10.3390/cancers13174405
pmc: PMC8430987
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : California Pacific Medical Center Foundation
ID : 280-101017-1220
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