Heat Shock Proteins 27, 70, and 110: Expression and Prognostic Significance in Colorectal Cancer.
HSP110
HSP27
HSP70
colorectal carcinoma
heat shock protein
prognosis
survival
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
31 Aug 2021
31 Aug 2021
Historique:
received:
24
06
2021
revised:
26
07
2021
accepted:
29
08
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
11
9
2021
Statut:
epublish
Résumé
Heat shock proteins (HSPs) are evolutionarily conserved chaperones occurring in virtually all living organisms playing a key role in the maintenance of cellular homeostasis. They are constitutively expressed to prevent and repair protein damage following various physiological and environmental stressors. HSPs are overexpressed in various types of cancers to provide cytoprotective function, and they have been described to influence prognosis and response to therapy. Moreover, they have been used as a tumor marker in blood serum biochemistry and they represent a potentially promising therapeutic target. To clarify prognostic significance of two canonical HSPs (27 and 70) and less known HSP110 (previously known as HSP105) in colorectal carcinoma (CRC), we retrospectively performed HSP immunohistochemistry on tissue microarrays from formalin-fixed paraffin-embedded tumor tissue from 297 patients with known follow-up. Survival analysis (univariate Kaplan-Meier analysis with the log-rank test and multivariate Cox regression) revealed significantly shorter overall survival (OS, mean 5.54 vs. 7.07,
Identifiants
pubmed: 34503216
pii: cancers13174407
doi: 10.3390/cancers13174407
pmc: PMC8431468
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Czech Health Research Council
ID : NU21J-03-00019
Organisme : Univerzita Karlova v Praze
ID : PROGRES Q28
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