Moderate Altitude Residence Reduces Male Colorectal and Female Breast Cancer Mortality More Than Incidence: Therapeutic Implications?
altitude
breast
climate
colorectal
disease
lifestyle
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
01 Sep 2021
01 Sep 2021
Historique:
received:
22
07
2021
revised:
30
08
2021
accepted:
31
08
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
11
9
2021
Statut:
epublish
Résumé
Living at moderate altitude may be associated with health benefits, including reduced mortality from male colorectal and female breast cancer. We aimed to determine altitude-dependent incidence and mortality rates of those cancers and put them in the context of altitude-associated lifestyle differences. Incidence cases and deaths of male colorectal cancer ( The age-standardized incidence and mortality rates of male colorectal cancer decreased by 24.0% and 44.2%, and that of female breast cancer by 6.5% and 26.2%, respectively, from the lowest to the highest altitude level. Higher physical activity levels and lower body mass index for both sexes living at higher altitudes were found. Living at a moderate altitude was associated with a reduced incidence and (more pronounced) mortality from colorectal and breast cancer. Our results suggest a complex interaction between specific climate conditions and lifestyle behaviours. These observations may, in certain cases, support decision making when changing residence.
Sections du résumé
BACKGROUND
BACKGROUND
Living at moderate altitude may be associated with health benefits, including reduced mortality from male colorectal and female breast cancer. We aimed to determine altitude-dependent incidence and mortality rates of those cancers and put them in the context of altitude-associated lifestyle differences.
METHODS
METHODS
Incidence cases and deaths of male colorectal cancer (
RESULTS
RESULTS
The age-standardized incidence and mortality rates of male colorectal cancer decreased by 24.0% and 44.2%, and that of female breast cancer by 6.5% and 26.2%, respectively, from the lowest to the highest altitude level. Higher physical activity levels and lower body mass index for both sexes living at higher altitudes were found.
CONCLUSIONS
CONCLUSIONS
Living at a moderate altitude was associated with a reduced incidence and (more pronounced) mortality from colorectal and breast cancer. Our results suggest a complex interaction between specific climate conditions and lifestyle behaviours. These observations may, in certain cases, support decision making when changing residence.
Identifiants
pubmed: 34503229
pii: cancers13174420
doi: 10.3390/cancers13174420
pmc: PMC8430507
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Aging (Albany NY). 2016 Oct 2;8(10):2603-2604
pubmed: 27705903
Nat Rev Cancer. 2006 Aug;6(8):583-92
pubmed: 16862189
Br J Cancer. 2007 Mar 12;96(5):821-7
pubmed: 17311023
J Clin Oncol. 2008 Aug 20;26(24):3958-64
pubmed: 18711185
Obesity (Silver Spring). 2014 Sep;22(9):2080-90
pubmed: 24890677
Mech Ageing Dev. 2017 Jul;165(Pt B):147-155
pubmed: 28390822
Br J Sports Med. 2020 May;54(10):582-591
pubmed: 31296585
Cancer Lett. 2020 Aug 28;486:1-7
pubmed: 32439418
High Alt Med Biol. 2002 Summer;3(2):245-6
pubmed: 12162867
BMC Cancer. 2018 Sep 20;18(1):906
pubmed: 30236083
BMJ. 2020 Jan 8;368:l6669
pubmed: 31915124
Cell. 2009 Mar 6;136(5):839-851
pubmed: 19217150
Br J Cancer. 2002 Nov 18;87(11):1234-45
pubmed: 12439712
Int J Epidemiol. 2002 Feb;31(1):78-85
pubmed: 11914299
High Alt Med Biol. 2018 Jun;19(2):116-123
pubmed: 29389240
World J Gastroenterol. 2015 May 7;21(17):5167-75
pubmed: 25954090
Integr Cancer Ther. 2018 Jun;17(2):217-225
pubmed: 28589744
Curr Vasc Pharmacol. 2012 Nov;10(6):700-1
pubmed: 23259558
Nutr Rev. 2020 Jan 1;78(1):1-18
pubmed: 31393566
Hum Biol. 2000 Feb;72(1):201-28
pubmed: 10721618
Cancer Lett. 2010 Oct 1;296(1):17-26
pubmed: 20378243
Epidemiol Rev. 2017 Jan 1;39(1):71-92
pubmed: 28453622
Cell Metab. 2018 Jan 9;27(1):10-21
pubmed: 29056514
Semin Oncol Nurs. 2016 Aug;32(3):241-54
pubmed: 27539279
J Clin Oncol. 2006 Aug 1;24(22):3535-41
pubmed: 16822843
Cell Res. 2017 Feb;27(2):302-305
pubmed: 27608935
Am Heart J. 2013 Jul;166(1):71-5
pubmed: 23816024
Clujul Med. 2018;91(2):188-196
pubmed: 29785157
Acta Physiol Scand. 1998 Apr;162(4):455-9
pubmed: 9597111
Aging (Albany NY). 2019 Dec 28;11(24):12708-12732
pubmed: 31884419
Aging Dis. 2013 Dec 05;5(4):274-80
pubmed: 25110611
J Clin Invest. 2013 Aug;123(8):3395-403
pubmed: 23867626
Breast Cancer Res Treat. 2015 Nov;154(2):213-24
pubmed: 26546245
Cell. 2012 Feb 3;148(3):399-408
pubmed: 22304911
Front Physiol. 2017 Jan 04;7:658
pubmed: 28101063
J Appl Physiol (1985). 1999 Dec;87(6):1997-2006
pubmed: 10601141
J Epidemiol Community Health. 2012 Jul;66(7):e17
pubmed: 21406589
N Engl J Med. 1977 Mar 17;296(11):581-5
pubmed: 840241
Br J Cancer. 2020 Nov;123(11):1705-1712
pubmed: 32929196
Gastroenterology. 2015 May;148(6):1244-60.e16
pubmed: 25575572
Science. 1997 Oct 17;278(5337):407-11
pubmed: 9334291
Environ Monit Assess. 2019 Feb 9;191(3):152
pubmed: 30739209
Hypoxia (Auckl). 2015 Dec 11;3:83-92
pubmed: 27774485
Int J Sports Med. 2006 Aug;27(8):629-35
pubmed: 16874590
Nat Rev Endocrinol. 2016 Jul;12(7):378-80
pubmed: 27230948
J Environ Pathol Toxicol Oncol. 2002;21(3):205-12
pubmed: 12435073
Lancet. 2016 Jan 16;387(10015):251-72
pubmed: 26510778
Circulation. 2009 Aug 11;120(6):495-501
pubmed: 19635973
J Appl Physiol (1985). 2010 Feb;108(2):343-8
pubmed: 19959769
Photochem Photobiol Sci. 2017 Mar 16;16(3):374-380
pubmed: 28009890
Med Sci Sports Exerc. 2017 May;49(5):948-954
pubmed: 28009787
Cancer Res. 2018 Aug 15;78(16):4790-4799
pubmed: 29921691
Br J Cancer. 2020 Mar;122(7):1085-1093
pubmed: 32037402
Front Endocrinol (Lausanne). 2018 Nov 12;9:658
pubmed: 30483215
Aviat Space Environ Med. 2008 Sep;79(9):875-82
pubmed: 18785356