Anthracyclines Strike Back: Rediscovering Non-Pegylated Liposomal Doxorubicin in Current Therapeutic Scenarios of Breast Cancer.

anthracyclines breast cancer hormone receptor metastatic non-pegylated liposomal doxorubicin triple negative

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
01 Sep 2021
Historique:
received: 28 06 2021
revised: 27 08 2021
accepted: 31 08 2021
entrez: 10 9 2021
pubmed: 11 9 2021
medline: 11 9 2021
Statut: epublish

Résumé

Anthracyclines are among the most active chemotherapies (CT) in breast cancer (BC). However, cardiotoxicity is a risk and peculiar side effect that has been limiting their use in clinical practice, especially after the introduction of taxanes. Non-pegylated liposomal doxorubicin (NPLD) has been developed to optimize the toxicity profile induced by anthracyclines, while maintaining its unquestionable therapeutic index, thanks to its delivering characteristics that increase its diffusion in tumor tissues and reduce it in normal tissues. This feature allows NPLD to be safely administered beyond the standard doxorubicin maximum cumulative dose of 450-480 mg/m

Identifiants

pubmed: 34503231
pii: cancers13174421
doi: 10.3390/cancers13174421
pmc: PMC8430783
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Références

Cochrane Database Syst Rev. 2006 Oct 18;(4):CD005006
pubmed: 17054231
Clin Cancer Res. 2009 Jan 1;15(1):307-14
pubmed: 19118059
Hematol Oncol. 2020 Oct;38(4):478-486
pubmed: 32542788
BMC Cancer. 2018 Oct 25;18(1):1037
pubmed: 30359235
Anticancer Drugs. 2005 Jan;16(1):21-9
pubmed: 15613900
BMC Med. 2019 Jan 9;17(1):8
pubmed: 30621698
Cancer Res. 1986 May;46(5):2295-9
pubmed: 3697976
PLoS One. 2015 Jul 23;10(7):e0133569
pubmed: 26204517
Cancers (Basel). 2020 Nov 25;12(12):
pubmed: 33255658
Eur Heart J Cardiovasc Imaging. 2017 May 01;18(8):930-936
pubmed: 28379383
Front Oncol. 2019 Aug 13;9:759
pubmed: 31456944
Clin Pharmacokinet. 2003;42(5):419-36
pubmed: 12739982
Ann Oncol. 2011 Jan;22(1):74-79
pubmed: 20603435
Clin Breast Cancer. 2012 Oct;12(5):313-21
pubmed: 22728026
Br J Haematol. 2005 Dec;131(5):561-78
pubmed: 16351632
Front Cardiovasc Med. 2020 Mar 18;7:26
pubmed: 32258060
Int J Oncol. 2014 Nov;45(5):2137-42
pubmed: 25176223
J Clin Oncol. 1985 Jun;3(6):818-26
pubmed: 3859587
Cancer Treat Rev. 2016 Nov;50:129-141
pubmed: 27665540
Ann Oncol. 2014 Mar;25(3):592-598
pubmed: 24401928
Breast. 2013 Dec;22(6):1101-7
pubmed: 24074879
Cancer Chemother Pharmacol. 2009 Jul;64(2):401-6
pubmed: 19104816
Eur J Cancer. 2011 Nov;47(16):2396-402
pubmed: 21920729
J Cancer. 2014 Apr 25;5(6):398-405
pubmed: 24847380
Hematol Oncol. 2018 Feb;36(1):68-75
pubmed: 28524259
J Clin Oncol. 2005 Nov 1;23(31):7794-803
pubmed: 16172456
ESMO Open. 2021 Apr;6(2):100099
pubmed: 33819752
Ann Oncol. 2004 Oct;15(10):1527-34
pubmed: 15367414
Int J Mol Sci. 2019 Dec 18;21(1):
pubmed: 31861465
Future Oncol. 2020 Aug;16(22):1629-1637
pubmed: 32501121
Lancet Oncol. 2019 Oct;20(10):1360-1369
pubmed: 31494037
Ann Oncol. 2011 Feb;22(2):257-67
pubmed: 20956616
Pharmaceutics. 2017 Mar 27;9(2):
pubmed: 28346375
Sci Rep. 2020 Oct 28;10(1):18481
pubmed: 33116159
Eur J Cancer. 2011 Sep;47(14):2091-8
pubmed: 21665463
Ann Oncol. 2019 Oct 1;30(10):1674
pubmed: 31236598
J Clin Oncol. 2001 Mar 1;19(5):1444-54
pubmed: 11230490
Lancet Oncol. 2014 Jun;15(7):747-56
pubmed: 24794243
Int J Breast Cancer. 2014;2014:984067
pubmed: 24527216
Eur J Cancer. 2021 May;149:134-152
pubmed: 33862496
Clin Cancer Res. 2010 Dec 1;16(23):5664-78
pubmed: 20829328
Crit Rev Oncol Hematol. 2011 Oct;80(1):160-70
pubmed: 21035352
J Clin Oncol. 2021 Nov 10;39(32):3541-3545
pubmed: 34406849
Ann Oncol. 2020 Dec;31(12):1623-1649
pubmed: 32979513
Cancer. 2002 Jan 1;94(1):25-36
pubmed: 11815957
Breast Cancer Res Treat. 2019 Apr;174(2):433-442
pubmed: 30536182
Breast. 2010 Oct;19(5):333-8
pubmed: 20185313
Breast. 2017 Feb;31:186-191
pubmed: 27886643
J Natl Compr Canc Netw. 2021 May 01;19(5):484-493
pubmed: 34794122
J Natl Cancer Inst. 2020 Nov 1;112(11):1089-1097
pubmed: 32407488
Syst Rev. 2017 Apr 12;6(1):79
pubmed: 28403893
Ann Oncol. 2005 Oct;16(10):1624-31
pubmed: 16030028
N Engl J Med. 2012 Jan 12;366(2):109-19
pubmed: 22149875
J Clin Oncol. 2009 Aug 1;27(22):3611-9
pubmed: 19470941
Ann Oncol. 2011 Feb;22(2):315-20
pubmed: 20693299
N Engl J Med. 2012 Nov 8;367(19):1783-91
pubmed: 23020162
Am J Clin Oncol. 1989 Feb;12(1):57-62
pubmed: 2643296
Int J Cardiol. 2017 May 15;235:147-153
pubmed: 28268088
J Clin Oncol. 2000 Sep;18(17):3115-24
pubmed: 10963640
J Clin Oncol. 1991 Dec;9(12):2148-52
pubmed: 1960557
J Clin Oncol. 2021 Dec 10;39(35):3938-3958
pubmed: 34324366
Circ Heart Fail. 2013 May;6(3):420-6
pubmed: 23425978

Auteurs

Francesco Schettini (F)

Translational Genomics and Targeted Therapies in Solid Tumors Research Group, 08036 Barcelona, Spain.
Department of Medical Oncology, Hospital Clinic of Barcelona, 08036 Barcelona, Spain.

Mario Giuliano (M)

Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy.

Matteo Lambertini (M)

Department of Internal Medicine and Medical Specialties (DiMI), School of Medicine, University of Genova, 16132 Genova, Italy.
Department of Medical Oncology, U.O.C Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.

Rupert Bartsch (R)

Division of Oncology, Department of Medicine 1, Medical University of Vienna, 1090 Vienna, Austria.

David James Pinato (DJ)

Division of Cancer, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK.
Department of Translational Medicine, Università del Piemonte Orientale "A. Avogadro", 28100 Novara, Italy.

Concetta Elisa Onesti (CE)

Clinical and Oncological Research Department, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.

Nadia Harbeck (N)

Breast Center, Department OB&GYN and CCCLMU, LMU University Hospital, 81377 Munich, Germany.

Diana Lüftner (D)

Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.

Sylvie Rottey (S)

Department of Medical Oncology, UZ Gent, 9000 Gent, Belgium.

Peter A van Dam (PA)

Oncology Department, University Hospital Antwerp (UZA), 2650 Edegem, Belgium.

Khalil Zaman (K)

Oncology Department, Lausanne University Hospital CHUV, 1011 Lausanne, Switzerland.

Giorgio Mustacchi (G)

Division of Medical Oncology, University of Trieste, 34127 Trieste, Italy.

Joseph Gligorov (J)

Department of Medical Oncology, Tenon Hospital, Institut Universitaire de Cancérologie AP-HP, Sorbonne University, 75004 Paris, France.

Ahmad Awada (A)

Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles, 1000 Bruxelles, Belgium.

Mario Campone (M)

Division of Medical Oncology, Institut de Cancérologie de l'Ouest-Pays de la Loire, 44800 Saint-Herblain, France.

Hans Wildiers (H)

Department of General Medical Oncology, University Hospital Leuven, 3000 Leuven, Belgium.

Alessandra Gennari (A)

Department of Translational Medicine, Università del Piemonte Orientale "A. Avogadro", 28100 Novara, Italy.

Vivianne C G Tjan-Heijnen (VCG)

Division of Medical Oncology, Maastricht University Medical Center (MUMC), 6229 Maastricht, The Netherlands.

Javier Cortes (J)

Oncology Department, IOB Institute of Oncology, Quiron Group, 08023 Madrid, Spain.
Vall d'Hebron Institute of Oncology (VHIO), Centro Cellex, 08035 Carrer de Natzaret, Spain.

Mariavittoria Locci (M)

Department of Neuroscience, Reproductive Medicine, Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.

Ida Paris (I)

Department of Woman and Child Health and Public Health, Woman Health Area, Fondazione Policlinico Universitario A, Gemelli IRCCS, 00168 Rome, Italy.

Lucia Del Mastro (L)

Department of Internal Medicine and Medical Specialties (DiMI), School of Medicine, University of Genova, 16132 Genova, Italy.
Department of Medical Oncology, U.O.C Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.

Sabino De Placido (S)

Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy.

Miguel Martín (M)

Departamento de Medicina, Instituto de Investigación Sanitaria Gregorio Marañón Universidad Complutense, 28007 Madrid, Spain.

Guy Jerusalem (G)

Division of Medical Oncology, CHU Sart Tilman Liège and University of Liège, 4000 Liège, Belgium.

Sergio Venturini (S)

Management Department, University of Turin, 10124 Torino, Italy.

Giuseppe Curigliano (G)

Istituto Europeo di Oncologia, IRCCS ed Università di Milano, 20141 Milano, Italy.

Daniele Generali (D)

Department of Medicine, Surgery and Health Sciences, University of Trieste, 34127 Trieste, Italy.
Multidisciplinary Unit of Breast Pathology and Translational Research, Cremona Hospital, Viale Concordia 1, 26100 Cremona, Italy.

Classifications MeSH