MRI-Determined Psoas Muscle Fat Infiltration Correlates with Severity of Weight Loss during Cancer Cachexia.
cancer cachexia
magnetic resonance imaging
proton density fat fraction (PDFF)
skeletal muscle
weight loss
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
02 Sep 2021
02 Sep 2021
Historique:
received:
12
08
2021
revised:
29
08
2021
accepted:
30
08
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
11
9
2021
Statut:
epublish
Résumé
To evaluate the suitability of psoas and erector spinae muscle proton density fat fraction (PDFF) and fat volume as biomarkers for monitoring cachexia severity in an oncological cohort, and to evaluate regional variances in muscle parameters over time. In this prospective study, 58 oncological patients were examined by a 3 T MRI receiving between one and five scans. Muscle volume and PDFF were measured, segmentation masks were divided into proximal, middle and distal muscle section. A regional variation of fat distribution in erector spinae muscle at baseline was found ( In erector spinae muscles, a regional variation of fat distribution at baseline and relative maximum change of muscle parameters was observed. Our results indicate that psoas muscle PDFF and fat volume could serve as MRI-determined biomarkers for early risk stratification and disease monitoring regarding progression and severity of weight loss in cancer cachexia.
Identifiants
pubmed: 34503243
pii: cancers13174433
doi: 10.3390/cancers13174433
pmc: PMC8431175
pii:
doi:
Types de publication
Journal Article
Langues
eng
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