The Hidden Treasures of Preoperative Blood Assessment in Oral Cancer: A Potential Source of Biomarkers.
fibrinogen
head and neck cancer
oral squamous cell carcinoma
platelet-to-lymphocyte ratio
preoperative
prognostic
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
05 Sep 2021
05 Sep 2021
Historique:
received:
24
07
2021
revised:
31
08
2021
accepted:
02
09
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
11
9
2021
Statut:
epublish
Résumé
(1) Background: Oral squamous cell carcinoma (OSCC) is a common malignancy, and the impact of immune and inflammatory mechanisms in its development and progression are of major interest. The aim of our study is to assess the prognostic potential of circulating immune and inflammatory elements determined preoperatively in patients with OSCC, as well as the development of a new compound parameter with predictive value. (2) Methods: We assessed preoperative fibrinogen (Fib) and the platelet-to-lymphocyte ratio (PLR) in 111 OSCC patients. Using a mathematic algorithm, we determined a composite parameter with cumulative information from Fib and PLR, named Fibrinogen-PLR Algorithm (FiPLA). Survival analysis, followed by bivariate and multivariate analyses, was subsequently conducted. (3) Results: Increased preoperative Fib and PLR levels were associated with poor outcome in OSCC (
Identifiants
pubmed: 34503285
pii: cancers13174475
doi: 10.3390/cancers13174475
pmc: PMC8430940
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministerul Cercetării şi Inovării
ID : PN 19.29.01.04
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