Hybrid Formation and Fusion of Cancer Cells In Vitro and In Vivo.
cell fusion
heterokaryon-to-synkaryon transition
horizontal gene transfer/lateral gene transfer
hybrid cell formation
mesenchymal stroma-/stem-like cells
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
06 Sep 2021
06 Sep 2021
Historique:
received:
17
08
2021
revised:
02
09
2021
accepted:
03
09
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
11
9
2021
Statut:
epublish
Résumé
The generation of cancer hybrid cells by intra-tumoral cell fusion opens new avenues for tumor plasticity to develop cancer stem cells with altered properties, to escape from immune surveillance, to change metastatic behavior, and to broaden drug responsiveness/resistance. Genomic instability and chromosomal rearrangements in bi- or multinucleated aneuploid cancer hybrid cells contribute to these new functions. However, the significance of cell fusion in tumorigenesis is controversial with respect to the low frequency of cancer cell fusion events and a clonal advantage of surviving cancer hybrid cells following a post-hybrid selection process. This review highlights alternative processes of cancer hybrid cell development such as entosis, emperipolesis, cannibalism, therapy-induced polyploidization/endoreduplication, horizontal or lateral gene transfer, and focusses on the predominant mechanisms of cell fusion. Based upon new properties of cancer hybrid cells the arising clinical consequences of the subsequent tumor heterogeneity after cancer cell fusion represent a major therapeutic challenge.
Identifiants
pubmed: 34503305
pii: cancers13174496
doi: 10.3390/cancers13174496
pmc: PMC8431460
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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