The Role of Mitochondrial Genes in Neurodegenerative Disorders.
Alzheimer's disease
Parkinson's disease
amyotrophic lateral sclerosis
mtDNA
multiple sclerosis
neurodegeneration
stroke
Journal
Current neuropharmacology
ISSN: 1875-6190
Titre abrégé: Curr Neuropharmacol
Pays: United Arab Emirates
ID NLM: 101157239
Informations de publication
Date de publication:
2022
2022
Historique:
received:
11
04
2021
revised:
09
07
2021
accepted:
07
09
2021
pubmed:
11
9
2021
medline:
17
5
2022
entrez:
10
9
2021
Statut:
ppublish
Résumé
Mitochondrial disorders are clinically heterogeneous, resulting from nuclear gene and mitochondrial mutations that disturb the mitochondrial functions and dynamics. There is a lack of evidence linking mtDNA mutations to neurodegenerative disorders, mainly due to the absence of noticeable neuropathological lesions in postmortem samples. This review describes various gene mutations in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, and stroke. These abnormalities, including PINK1, Parkin, and SOD1 mutations, seem to reveal mitochondrial dysfunctions due to either mtDNA mutation or deletion, the mechanism of which remains unclear in depth.
Identifiants
pubmed: 34503413
pii: CN-EPUB-117786
doi: 10.2174/1570159X19666210908163839
pmc: PMC9881096
doi:
Substances chimiques
DNA, Mitochondrial
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
824-835Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
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