Might life-threatening acute pulmonary edema occur after using recombinant tissue plasminogen activator? A case report.
Acute ischemic stroke
Acute pulmonary edema
Case report
Forensic pathology
Recombinant tissue plasminogen activator
Journal
BMC neurology
ISSN: 1471-2377
Titre abrégé: BMC Neurol
Pays: England
ID NLM: 100968555
Informations de publication
Date de publication:
09 Sep 2021
09 Sep 2021
Historique:
received:
21
09
2020
accepted:
27
08
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
16
10
2021
Statut:
epublish
Résumé
Recombinant tissue plasminogen activator (rt-pa) is the first-line drug for the treatment of acute ischemic stroke, and can lead to some complications.There were rare reports of death due to acute pulmonary edema during rt-pa thrombolysis treatment. This study reports a 30-year-old man was diagnosed with acute ischemic stroke and underwent rt-pa thrombolytic therapy. Finally he died despite active rescue. The autopsy revealed that he died of acute pulmonary edema. This case suggests that it is necessary to pay close attention to the changes of vital signs during thrombolysis and be aware of possibility of pulmonary edema during thrombolysis.
Sections du résumé
BACKGROUND
BACKGROUND
Recombinant tissue plasminogen activator (rt-pa) is the first-line drug for the treatment of acute ischemic stroke, and can lead to some complications.There were rare reports of death due to acute pulmonary edema during rt-pa thrombolysis treatment.
CASE PRESENTATION
METHODS
This study reports a 30-year-old man was diagnosed with acute ischemic stroke and underwent rt-pa thrombolytic therapy. Finally he died despite active rescue.
CONCLUSIONS
CONCLUSIONS
The autopsy revealed that he died of acute pulmonary edema. This case suggests that it is necessary to pay close attention to the changes of vital signs during thrombolysis and be aware of possibility of pulmonary edema during thrombolysis.
Identifiants
pubmed: 34503474
doi: 10.1186/s12883-021-02371-w
pii: 10.1186/s12883-021-02371-w
pmc: PMC8427873
doi:
Substances chimiques
Fibrinolytic Agents
0
Recombinant Proteins
0
Tissue Plasminogen Activator
EC 3.4.21.68
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
346Subventions
Organisme : Guangzhou Sci-Tech Project
ID : 201804010307
Informations de copyright
© 2021. The Author(s).
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