Current understanding of ferroptosis in the progression and treatment of pancreatic cancer.
Ferroptosis
Iron accumulation
Lipid peroxidation
Pancreatic cancer
Journal
Cancer cell international
ISSN: 1475-2867
Titre abrégé: Cancer Cell Int
Pays: England
ID NLM: 101139795
Informations de publication
Date de publication:
09 Sep 2021
09 Sep 2021
Historique:
received:
04
06
2021
accepted:
19
08
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
11
9
2021
Statut:
epublish
Résumé
Pancreatic cancer is a highly malignant tumour of the digestive tract. Despite advances in treatment, its 5-year survival rate remains low, and its prognosis is the worst among all cancers; innovative therapeutic methods are needed. Ferroptosis is a form of regulatory cell death driven by iron accumulation and lipid peroxidation. Recent studies have found that ferroptosis plays an important role in the development and treatment response of tumours, particularly pancreatic cancer. This article reviews the current understanding of the mechanism of ferroptosis and ferroptosis-related treatment in pancreatic cancer.
Identifiants
pubmed: 34503532
doi: 10.1186/s12935-021-02166-6
pii: 10.1186/s12935-021-02166-6
pmc: PMC8427874
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
480Subventions
Organisme : the Science and Technology Projects of Chengguan District in Lanzhou
ID : 2020-2-11-4
Informations de copyright
© 2021. The Author(s).
Références
Biochem Biophys Res Commun. 2020 Dec 17;533(4):1464-1469
pubmed: 33268027
Cell Death Differ. 2018 Aug;25(8):1457-1472
pubmed: 29348676
Nat Commun. 2021 Jan 28;12(1):647
pubmed: 33510144
Oncoscience. 2015 May 02;2(5):517-32
pubmed: 26097885
Nature. 2019 Aug;572(7769):402-406
pubmed: 31341276
Dev Cell. 2020 Aug 24;54(4):447-454.e4
pubmed: 32652074
Nat Cell Biol. 2018 Oct;20(10):1181-1192
pubmed: 30202049
Genes Dev. 2018 Mar 1;32(5-6):327-340
pubmed: 29593066
Biochem Biophys Res Commun. 2021 Jan 15;536:100-106
pubmed: 33373853
Cancer Gene Ther. 2021 Feb;28(1-2):55-63
pubmed: 32457486
Mol Cancer. 2020 Feb 27;19(1):43
pubmed: 32106859
Biochem Biophys Res Commun. 2016 Mar 11;471(3):373-9
pubmed: 26869514
Nat Commun. 2020 Dec 11;11(1):6339
pubmed: 33311482
J Cancer Res Clin Oncol. 2018 Dec;144(12):2329-2337
pubmed: 30167889
Am J Cancer Res. 2020 Apr 01;10(4):1182-1193
pubmed: 32368394
Oxid Med Cell Longev. 2019 Jun 10;2019:3150145
pubmed: 31281572
Dev Cell. 2018 Aug 20;46(4):441-455.e8
pubmed: 30100261
Nature. 2019 Nov;575(7784):693-698
pubmed: 31634899
Cell Res. 2020 Feb;30(2):146-162
pubmed: 31949285
Genes Dev. 2018 May 1;32(9-10):602-619
pubmed: 29802123
Annu Rev Nutr. 2018 Aug 21;38:97-125
pubmed: 30130469
Angew Chem Int Ed Engl. 2020 Oct 12;59(42):18755-18762
pubmed: 32634290
Cell Chem Biol. 2021 Jun 17;28(6):765-775.e5
pubmed: 33539732
Aging (Albany NY). 2021 Apr 4;13(7):10396-10414
pubmed: 33819918
Arch Biochem Biophys. 1974 Jun;162(2):493-501
pubmed: 4210077
Br J Cancer. 2008 May 6;98(9):1540-7
pubmed: 18392050
Cancers (Basel). 2020 Nov 26;12(12):
pubmed: 33255972
Aging (Albany NY). 2020 Feb 18;12(4):3662-3681
pubmed: 32074079
J Cell Mol Med. 2021 Feb;25(4):2163-2175
pubmed: 33345387
Semin Cancer Biol. 2018 Dec;53:125-138
pubmed: 30071257
Biochim Biophys Acta Gen Subj. 2020 Apr;1864(4):129539
pubmed: 31958545
Free Radic Biol Med. 2019 Mar;133:130-143
pubmed: 30268886
Gastric Cancer. 2020 Mar;23(2):241-259
pubmed: 31520166
Oncol Lett. 2019 Mar;17(3):3001-3008
pubmed: 30854078
J Clin Oncol. 2020 Jun 1;38(16):1763-1773
pubmed: 32105518
Oncol Lett. 2018 May;15(5):8125-8133
pubmed: 29731920
ACS Appl Mater Interfaces. 2018 Dec 26;10(51):44231-44239
pubmed: 30499652
Ann Transl Med. 2020 Nov;8(21):1347
pubmed: 33313092
Cancer Res. 2018 Jul 1;78(13):3484-3496
pubmed: 29588351
Free Radic Biol Med. 2019 Mar;133:144-152
pubmed: 30219704
Cancer Res Treat. 2018 Apr;50(2):445-460
pubmed: 28494534
Biochem Biophys Res Commun. 2020 Feb 19;522(4):1063-1068
pubmed: 31822343
Nat Chem Biol. 2014 Jan;10(1):9-17
pubmed: 24346035
Chem Biol. 2008 Mar;15(3):234-45
pubmed: 18355723
Radiother Oncol. 2021 Jan;154:60-69
pubmed: 32861703
Cell Cycle. 2020 Oct;19(19):2411-2425
pubmed: 32816618
Sci Rep. 2018 Jan 12;8(1):574
pubmed: 29330409
J Biol Chem. 2014 Nov 28;289(48):33425-41
pubmed: 25305013
Trends Cell Biol. 2016 Mar;26(3):165-176
pubmed: 26653790
Nature. 2019 May;569(7755):270-274
pubmed: 31043744
Oncotarget. 2018 Aug 17;9(64):32280-32297
pubmed: 30190786
J Biol Chem. 2001 Mar 30;276(13):10407-12
pubmed: 11136724
Biochem Biophys Res Commun. 2020 Oct 22;531(4):581-587
pubmed: 32811647
Nat Rev Clin Oncol. 2021 May;18(5):280-296
pubmed: 33514910
Hepatology. 2016 Aug;64(2):488-500
pubmed: 27015352
Front Pharmacol. 2020 Oct 16;11:568993
pubmed: 33178018
Cancer Discov. 2019 Dec;9(12):1673-1685
pubmed: 31554642
Cell Death Dis. 2018 Jul 9;9(7):753
pubmed: 29988039
N Engl J Med. 2019 Jul 25;381(4):317-327
pubmed: 31157963
Mol Ther Oncolytics. 2020 Jan 21;16:197-206
pubmed: 32099899
Elife. 2014 May 20;3:e02523
pubmed: 24844246
Dev Cell. 2019 Dec 2;51(5):575-586.e4
pubmed: 31735663
Cell. 2017 Oct 5;171(2):273-285
pubmed: 28985560
Nature. 2011 Mar 17;471(7338):363-7
pubmed: 21368763
Nature. 2020 Sep;585(7826):603-608
pubmed: 32939090
Nat Cell Biol. 2020 Feb;22(2):225-234
pubmed: 32029897
Aging (Albany NY). 2020 Nov 18;12(22):23217-23232
pubmed: 33221741
Breast Cancer Res. 2019 Aug 13;21(1):94
pubmed: 31409375
Science. 2020 Apr 3;368(6486):85-89
pubmed: 32241947
Redox Biol. 2020 Sep;36:101611
pubmed: 32863212
Autophagy. 2020 Nov;16(11):2069-2083
pubmed: 31920150
Nature. 2015 Apr 2;520(7545):57-62
pubmed: 25799988
Cancer Lett. 2018 Sep 28;432:180-190
pubmed: 29928961
Redox Biol. 2021 Jan;38:101807
pubmed: 33271455
PLoS One. 2019 Dec 4;14(12):e0225931
pubmed: 31800616
Biochem Biophys Res Commun. 2017 Sep 30;491(4):919-925
pubmed: 28756230
Cell Death Differ. 2019 Nov;26(11):2329-2343
pubmed: 30787392
Cell Death Differ. 2021 Apr;28(4):1222-1236
pubmed: 33097833
Cell Mol Life Sci. 2016 Jun;73(11-12):2195-209
pubmed: 27048822
Cell Death Dis. 2021 Jul 15;12(7):705
pubmed: 34262021
Autophagy. 2016 Aug 2;12(8):1425-8
pubmed: 27245739
Cancer Res. 2019 Aug 1;79(15):3877-3890
pubmed: 31175120
Autophagy. 2021 Apr;17(4):948-960
pubmed: 32186434
Cell Rep. 2021 Feb 23;34(8):108767
pubmed: 33626342
Cell. 2012 May 25;149(5):1060-72
pubmed: 22632970
J Biol Chem. 2013 May 24;288(21):14815-23
pubmed: 23592778
J Cell Mol Med. 2019 Aug;23(8):4900-4912
pubmed: 31232522