Oxidative stress, malaria, sickle cell disease, and innate immunity.
damage-associated molecular pattern
high-mannose glycans
malaria
oxidative stress
pathogen-associated molecular pattern
phagocytosis
sickle cell disease
Journal
Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
14
06
2021
revised:
15
08
2021
accepted:
16
08
2021
pubmed:
11
9
2021
medline:
21
10
2021
entrez:
10
9
2021
Statut:
ppublish
Résumé
Plasmodium falciparum shields from adaptive immunity in erythrocytes, but how might the innate immune system recognize infected cells? Replication by the parasite results in oxidative stress, causing surface expression of high-mannose glycans. These can act as pathogen-associated molecular patterns to stimulate phagocytosis in the spleen and the sickle cell allele enhances these responses.
Identifiants
pubmed: 34503910
pii: S1471-4906(21)00161-7
doi: 10.1016/j.it.2021.08.008
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
849-851Subventions
Organisme : Wellcome Trust
ID : 094847
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The University of Aberdeen has been granted a patent based on the work described in [8].