Mechanical Stimulation-Induced Calcium Signaling by Piezo1 Channel Activation in Human Odontoblast Reduces Dentin Mineralization.

Piezo channel dentin mechanosensitive channel odontoblast orofacial pain tooth pain

Journal

Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006

Informations de publication

Date de publication:
2021
Historique:
received: 03 05 2021
accepted: 03 08 2021
entrez: 10 9 2021
pubmed: 11 9 2021
medline: 11 9 2021
Statut: epublish

Résumé

Odontoblasts play critical roles in dentin formation and sensory transduction following stimuli on the dentin surface. Exogenous stimuli to the dentin surface elicit dentinal sensitivity through the movement of fluids in dentinal tubules, resulting in cellular deformation. Recently, Piezo1 channels have been implicated in mechanosensitive processes, as well as Ca

Identifiants

pubmed: 34504437
doi: 10.3389/fphys.2021.704518
pmc: PMC8421527
doi:

Types de publication

Journal Article

Langues

eng

Pagination

704518

Informations de copyright

Copyright © 2021 Matsunaga, Kimura, Ouchi, Nakamura, Ohyama, Ando, Nomura, Azuma, Ichinohe and Shibukawa.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Mayumi Matsunaga (M)

Department of Physiology, Tokyo Dental College, Tokyo, Japan.
Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan.

Maki Kimura (M)

Department of Physiology, Tokyo Dental College, Tokyo, Japan.

Takehito Ouchi (T)

Department of Physiology, Tokyo Dental College, Tokyo, Japan.

Takashi Nakamura (T)

Department of Biochemistry, Tokyo Dental College, Tokyo, Japan.

Sadao Ohyama (S)

Department of Physiology, Tokyo Dental College, Tokyo, Japan.

Masayuki Ando (M)

Department of Physiology, Tokyo Dental College, Tokyo, Japan.

Sachie Nomura (S)

Department of Physiology, Tokyo Dental College, Tokyo, Japan.

Toshifumi Azuma (T)

Department of Biochemistry, Tokyo Dental College, Tokyo, Japan.

Tatsuya Ichinohe (T)

Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan.

Yoshiyuki Shibukawa (Y)

Department of Physiology, Tokyo Dental College, Tokyo, Japan.

Classifications MeSH