Cerebral aspergillosis and facial acneiform lesions following initiation of ibrutinib in a patient with chronic lymphocytic leukemia.
Aspergillosis
Bruton’s Tyrosine Kinase Inhibitor
Invasive fungal infection
Journal
IDCases
ISSN: 2214-2509
Titre abrégé: IDCases
Pays: Netherlands
ID NLM: 101634540
Informations de publication
Date de publication:
2021
2021
Historique:
received:
28
09
2020
revised:
26
08
2021
accepted:
30
08
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
11
9
2021
Statut:
epublish
Résumé
A case of a 67-year-old male with CLL, presented with prolonged pancytopenia after his first cycle of fludarabine, cyclophosphamide, and rituximab (FCR) chemotherapy. He was then treated with ibrutinib oral monotherapy. Shortly after ibrutinib treatment initiation, he developed a brain abscess and pulmonary disease as a part of an invasive aspergillosis. The patient improved after brain abscess drainage and the anti-fungal therapy voriconazole. Upon resuming ibrutinib four months after his hospitalization, he developed extensive acneiform facial lesions. This case is the first to report on the development of two separate complications in one patient related to ibrutinib, namely,
Identifiants
pubmed: 34504767
doi: 10.1016/j.idcr.2021.e01263
pii: S2214-2509(21)00219-5
pmc: PMC8416634
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e01263Informations de copyright
© 2021 Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Clin Cancer Res. 2017 May 1;23(9):2154-2158
pubmed: 27797975
Blood. 2015 Mar 26;125(13):2062-7
pubmed: 25573991
Med Mycol Case Rep. 2019 Feb 28;24:27-29
pubmed: 30899641
Mycoses. 2019 Dec;62(12):1140-1147
pubmed: 31520441
Blood. 2018 May 24;131(21):2357-2366
pubmed: 29483101
EMBO Mol Med. 2015 Jan 30;7(3):240-58
pubmed: 25637383
Blood. 2018 Nov 1;132(18):1985-1988
pubmed: 30021784
Med Mycol Case Rep. 2019 Dec 05;27:17-21
pubmed: 31879587
N Engl J Med. 2018 Dec 27;379(26):2517-2528
pubmed: 30501481
Respir Med Case Rep. 2017 Mar 20;21:27-29
pubmed: 28377877
Nat Rev Cancer. 2018 Mar;18(3):148-167
pubmed: 29348577
N Engl J Med. 2016 Apr 21;374(16):1593-4
pubmed: 27096597
Clin Lymphoma Myeloma Leuk. 2017 Dec;17(12):834-851
pubmed: 28918995
Cancer Cell. 2017 Jun 12;31(6):833-843.e5
pubmed: 28552327
Br J Haematol. 2000 Aug;110(2):273-84
pubmed: 10971382
Haematologica. 2020 Jan 31;105(2):478-489
pubmed: 31171644
Leuk Lymphoma. 2017 Dec;58(12):2981-2982
pubmed: 28554246
Mycotoxin Res. 2018 Nov;34(4):257-268
pubmed: 30006720
Blood. 2018 Jan 25;131(4):379-386
pubmed: 29255067
Med Mal Infect. 2018 Jun;48(4):294-297
pubmed: 29402474