Effects of miRNAs, lncRNAs and circRNAs on osteoporosis as regulatory factors of bone homeostasis (Review).
Animals
Apoptosis
/ genetics
Autophagy
/ genetics
Bone and Bones
/ metabolism
Cell Differentiation
/ genetics
Cell Proliferation
/ genetics
Gene Expression
/ genetics
Gene Expression Regulation
/ genetics
Homeostasis
/ genetics
Humans
Mesenchymal Stem Cells
/ metabolism
MicroRNAs
/ genetics
Osteoblasts
/ metabolism
Osteoclasts
/ metabolism
Osteoporosis
/ genetics
RNA Processing, Post-Transcriptional
/ genetics
RNA, Circular
/ genetics
RNA, Long Noncoding
/ genetics
bone homeostasis
circRNA
lncRNA
miRNA
osteoporosis
Journal
Molecular medicine reports
ISSN: 1791-3004
Titre abrégé: Mol Med Rep
Pays: Greece
ID NLM: 101475259
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
22
03
2021
accepted:
25
08
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
29
1
2022
Statut:
ppublish
Résumé
Osteoporosis is a common metabolic bone disorder typically characterized by decreased bone mass and an increased risk of fracture. At present, the detailed molecular mechanism underlying the development of osteoporosis remains to be elucidated. Accumulating evidence shows that non‑coding (nc)RNAs, such as microRNAs (miRNAs), long ncRNAs (lncRNAs) and circular RNAs (circRNAs), play significant roles in osteoporosis through the post‑transcriptional regulation of gene expression as regulatory factors. Previous studies have demonstrated that ncRNAs participate in maintaining bone homeostasis by regulating physiological and developmental processes in osteoblasts, osteoclasts and bone marrow stromal cells. In the present review, the latest research investigating the involvement of miRNAs, lncRNAs and circRNAs in regulating the differentiation, proliferation, apoptosis and autophagy of cells that maintain the bone microenvironment in osteoporosis is summarized. Deeper insight into the aspects of osteoporosis pathogenesis involving the deregulation of ncRNAs could facilitate the development of therapeutic approaches for osteoporosis.
Identifiants
pubmed: 34505632
doi: 10.3892/mmr.2021.12428
pii: 788
pmc: PMC8441966
doi:
pii:
Substances chimiques
MicroRNAs
0
RNA, Circular
0
RNA, Long Noncoding
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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