A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects.
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
23 09 2021
23 09 2021
Historique:
pubmed:
11
9
2021
medline:
15
12
2021
entrez:
10
9
2021
Statut:
ppublish
Résumé
Mitragynine and 7-hydroxymitragynine (7OH) are the major alkaloids mediating the biological actions of the psychoactive plant kratom. To investigate the structure-activity relationships of mitragynine/7OH templates, we diversified the aromatic ring of the indole at the C9, C10, and C12 positions and investigated their G-protein and arrestin signaling mediated by mu opioid receptors (MOR). Three synthesized lead C9 analogs replacing the 9-OCH
Identifiants
pubmed: 34505767
doi: 10.1021/acs.jmedchem.1c01273
pmc: PMC8530377
mid: NIHMS1744753
doi:
Substances chimiques
Analgesics, Opioid
0
Receptors, Opioid, mu
0
Secologanin Tryptamine Alkaloids
0
mitragynine
EP479K822J
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
13873-13892Subventions
Organisme : NIDA NIH HHS
ID : R01 DA046487
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA045473
Pays : United States
Organisme : NIH HHS
ID : S10 OD026880
Pays : United States
Organisme : NIAAA NIH HHS
ID : R21 AA026949
Pays : United States
Organisme : NIDA NIH HHS
ID : R33 DA045884
Pays : United States
Organisme : NIH HHS
ID : S10 OD018522
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA034106
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA034049
Pays : United States
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