Elevated C-reactive protein in early COVID-19 predicts worse survival among hospitalized geriatric patients.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
20
05
2021
accepted:
18
08
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
23
9
2021
Statut:
epublish
Résumé
The objective of this cohort study was to determine whether elevated CRP in early COVID-19 was associated with 14-day mortality in geriatric patients. Plasma CRP levels at hospital admission and 14-day all-cause mortality were assessed in geriatric inpatients hospitalized for COVID-19. Potential confounders were age, sex, functional abilities, history of malignancies, hypertension, cardiomyopathy, albuminemia, number of acute health issues, use of antibiotics and respiratory treatments. Ninety-five participants (mean±SD 88.0±5.5years; 49.5%women; mean CRP, 76.7±77.5mg/L; mean albuminemia, 32.9±6.0g/L) were included. Sixteen participants who did not survive at day 14 exhibited higher CRP level at baseline than the others (120.3±71.2 versus 67.9±76.1 mg/L, P = 0.002). There was no difference in albuminemia (P = 0.329). Plasma CRP level was directly associated with 14-day mortality (fully adjusted HR = 1.11, P = 0.025). The cut-off for CRP associated with 14-day mortality was set at 35mg/L (sensitivity = 0.88; specificity = 0.56). Those with CRP<35mg/L had longer survival time than the others (log-rank P<0.001). Elevated CRP levels were associated with poorer 14-day survival in hospitalized geriatric COVID-19 patients.
Sections du résumé
BACKGROUND
The objective of this cohort study was to determine whether elevated CRP in early COVID-19 was associated with 14-day mortality in geriatric patients.
METHODS
Plasma CRP levels at hospital admission and 14-day all-cause mortality were assessed in geriatric inpatients hospitalized for COVID-19. Potential confounders were age, sex, functional abilities, history of malignancies, hypertension, cardiomyopathy, albuminemia, number of acute health issues, use of antibiotics and respiratory treatments.
RESULTS
Ninety-five participants (mean±SD 88.0±5.5years; 49.5%women; mean CRP, 76.7±77.5mg/L; mean albuminemia, 32.9±6.0g/L) were included. Sixteen participants who did not survive at day 14 exhibited higher CRP level at baseline than the others (120.3±71.2 versus 67.9±76.1 mg/L, P = 0.002). There was no difference in albuminemia (P = 0.329). Plasma CRP level was directly associated with 14-day mortality (fully adjusted HR = 1.11, P = 0.025). The cut-off for CRP associated with 14-day mortality was set at 35mg/L (sensitivity = 0.88; specificity = 0.56). Those with CRP<35mg/L had longer survival time than the others (log-rank P<0.001).
CONCLUSIONS
Elevated CRP levels were associated with poorer 14-day survival in hospitalized geriatric COVID-19 patients.
Identifiants
pubmed: 34506514
doi: 10.1371/journal.pone.0256931
pii: PONE-D-21-16624
pmc: PMC8432790
doi:
Substances chimiques
Biomarkers
0
CRP protein, human
0
Receptors, Immunologic
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0256931Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Clin Hemorheol Microcirc. 2021;77(3):311-322
pubmed: 33185593
J Clin Virol. 2020 Jun;127:104370
pubmed: 32344321
BMC Pulm Med. 2015 Mar 14;15:22
pubmed: 25888398
Intensive Care Med. 2020 Jun;46(6):1089-1098
pubmed: 32367170
Chin Med J (Engl). 2020 May 5;133(9):1032-1038
pubmed: 32118640
Nutrients. 2020 Nov 02;12(11):
pubmed: 33147894
Eur Radiol. 2021 Mar 30;:
pubmed: 33786655
Soins Gerontol. 1998 Jun;(13):23-7
pubmed: 9735854
JAMA Intern Med. 2020 Jul 1;180(7):934-943
pubmed: 32167524
Clin Geriatr Med. 2017 Nov;33(4):459-471
pubmed: 28991644
Thromb Haemost. 2021 Jan;121(1):98-101
pubmed: 33212544
J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S4-9
pubmed: 24833586
BMC Med Res Methodol. 2012 Jun 19;12:81
pubmed: 22712852
Crit Care Med. 2000 Sep;28(9):3137-45
pubmed: 11008971
J Am Med Dir Assoc. 2013 Dec;14(12):877-82
pubmed: 23792036
J Med Virol. 2020 Jul;92(7):856-862
pubmed: 32281668
Stroke. 2020 Jul;51(7):1924-1926
pubmed: 32496937
J Am Geriatr Soc. 2009 Sep;57(9):1721-3
pubmed: 19895442
Clin Infect Dis. 2020 Nov 19;71(16):2174-2179
pubmed: 32445579
Science. 2020 May 1;368(6490):473-474
pubmed: 32303591
Med Mal Infect. 2020 Jun;50(4):332-334
pubmed: 32243911
Clin Appl Thromb Hemost. 2020 Jan-Dec;26:1076029620938149
pubmed: 32677459
Mech Ageing Dev. 2007 Jan;128(1):92-105
pubmed: 17116321
J Allergy Clin Immunol. 2020 Jul;146(1):128-136.e4
pubmed: 32425269
Ann N Y Acad Sci. 2000 Jun;908:244-54
pubmed: 10911963
FEBS Lett. 2005 Apr 11;579(10):2035-9
pubmed: 15811314
Aging Cell. 2020 Oct;19(10):e13237
pubmed: 32955770
Clin Med (Lond). 2020 Sep;20(5):463-467
pubmed: 32934038
Biomark Res. 2020 Aug 31;8:37
pubmed: 32879731
Chest. 2009 Aug;136(2):471-480
pubmed: 19411291
J Leukoc Biol. 2017 Oct;102(4):977-988
pubmed: 28733462