Prenatal risk factors and neonatal DNA methylation in very preterm infants.
Adult
Age Factors
DNA Methylation
/ genetics
Epigenesis, Genetic
Female
Fetal Growth Retardation
/ genetics
Genome-Wide Association Study
Humans
Infant
Infant, Newborn
Infant, Premature
/ growth & development
Male
Pregnancy
Prenatal Exposure Delayed Effects
/ genetics
Risk Factors
Socioeconomic Factors
Buccal
Epigenetics
Epigenome-wide association study (EWAS)
Methylation
Neonatal
Prenatal
Preterm
Journal
Clinical epigenetics
ISSN: 1868-7083
Titre abrégé: Clin Epigenetics
Pays: Germany
ID NLM: 101516977
Informations de publication
Date de publication:
10 09 2021
10 09 2021
Historique:
received:
28
05
2021
accepted:
02
09
2021
entrez:
11
9
2021
pubmed:
12
9
2021
medline:
10
2
2022
Statut:
epublish
Résumé
Prenatal risk factors are related to poor health and developmental outcomes for infants, potentially via epigenetic mechanisms. We tested associations between person-centered prenatal risk profiles, cumulative prenatal risk models, and epigenome-wide DNA methylation (DNAm) in very preterm neonates. We studied 542 infants from a multi-center study of infants born < 30 weeks postmenstrual age. We assessed 24 prenatal risk factors via maternal report and medical record review. Latent class analysis was used to define prenatal risk profiles. DNAm was quantified from neonatal buccal cells using the Illumina MethylationEPIC Beadarray. We identified three latent profiles of women: a group with few risk factors (61%) and groups with elevated physical (26%) and psychological (13%) risk factors. Neonates born to women in higher risk subgroups had differential DNAm at 2 CpG sites. Higher cumulative prenatal risk was associated with methylation at 15 CpG sites, 12 of which were located in genes previously linked to physical and mental health and neurodevelopment. We observed associations between prenatal risk factors and DNAm in very preterm infants using both person-centered and cumulative risk approaches. Epigenetics offers a potential biological indicator of prenatal risk exposure.
Sections du résumé
BACKGROUND
Prenatal risk factors are related to poor health and developmental outcomes for infants, potentially via epigenetic mechanisms. We tested associations between person-centered prenatal risk profiles, cumulative prenatal risk models, and epigenome-wide DNA methylation (DNAm) in very preterm neonates.
METHODS
We studied 542 infants from a multi-center study of infants born < 30 weeks postmenstrual age. We assessed 24 prenatal risk factors via maternal report and medical record review. Latent class analysis was used to define prenatal risk profiles. DNAm was quantified from neonatal buccal cells using the Illumina MethylationEPIC Beadarray.
RESULTS
We identified three latent profiles of women: a group with few risk factors (61%) and groups with elevated physical (26%) and psychological (13%) risk factors. Neonates born to women in higher risk subgroups had differential DNAm at 2 CpG sites. Higher cumulative prenatal risk was associated with methylation at 15 CpG sites, 12 of which were located in genes previously linked to physical and mental health and neurodevelopment.
CONCLUSION
We observed associations between prenatal risk factors and DNAm in very preterm infants using both person-centered and cumulative risk approaches. Epigenetics offers a potential biological indicator of prenatal risk exposure.
Identifiants
pubmed: 34507616
doi: 10.1186/s13148-021-01164-9
pii: 10.1186/s13148-021-01164-9
pmc: PMC8434712
doi:
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
171Subventions
Organisme : NICHD NIH HHS
ID : R01 HD084515
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH019927
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023347
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD072267
Pays : United States
Informations de copyright
© 2021. The Author(s).
Références
J Perinatol. 2021 Mar 23;:
pubmed: 33758389
Environ Health Perspect. 2017 Apr;125(4):511-526
pubmed: 28362264
Pediatr Res. 2020 Mar;87(4):721-729
pubmed: 31600769
Epigenetics. 2015;10(5):361-72
pubmed: 25891251
Dev Med Child Neurol. 2012 Aug;54(8):710-5
pubmed: 22630341
Bioinformatics. 2013 Jan 15;29(2):189-96
pubmed: 23175756
Epigenetics. 2008 Mar-Apr;3(2):97-106
pubmed: 18536531
Genome Biol. 2015 Jan 24;16:14
pubmed: 25616342
Pediatrics. 2007 Dec;120(6):e1512-9
pubmed: 17984212
Bioinformatics. 2014 May 15;30(10):1363-9
pubmed: 24478339
Pediatrics. 2018 Oct;142(4):
pubmed: 30257918
J Perinat Neonatal Nurs. 2020 Apr/Jun;34(2):134-145
pubmed: 32332443
Environ Health Perspect. 2012 Oct;120(10):1425-31
pubmed: 22851337
Pediatrics. 2010 Jan;125(1):e90-8
pubmed: 19969621
Clin Epigenetics. 2020 Oct 19;12(1):151
pubmed: 33076993
Pediatr Res. 2017 Oct;82(4):614-619
pubmed: 28582386
Nat Commun. 2018 May 29;9(1):2098
pubmed: 29844566
Epigenetics. 2014 Jul;9(7):964-72
pubmed: 24751725
Infant Behav Dev. 2011 Jun;34(3):390-406
pubmed: 21477866
J Dev Behav Pediatr. 2014 Jul-Aug;35(6):394-407
pubmed: 25007063
Transl Psychiatry. 2012 Oct 23;2:e180
pubmed: 23092984
Arch Dis Child. 2017 Jan;102(1):97-102
pubmed: 27512082
EBioMedicine. 2018 Oct;36:410-428
pubmed: 30266294
Early Hum Dev. 2020 Mar;142:104954
pubmed: 32007912
Transl Psychiatry. 2018 Nov 7;8(1):244
pubmed: 30405117
BMC Genomics. 2016 Jun 22;17:469
pubmed: 27334613
Genome Biol. 2016 Oct 7;17(1):208
pubmed: 27717381
Transl Psychiatry. 2015 Apr 07;5:e545
pubmed: 25849984
Nat Commun. 2020 Jul 14;11(1):3512
pubmed: 32665545
Hum Mol Genet. 2018 Apr 1;27(7):1301-1308
pubmed: 29365106
Clin Epigenetics. 2017 Oct 3;9:107
pubmed: 29026448
Epigenetics. 2016;11(2):140-9
pubmed: 26889969
Dev Psychopathol. 2018 Oct;30(4):1269-1303
pubmed: 29229018
Sci Rep. 2019 Apr 19;9(1):6322
pubmed: 31004082
Pediatr Res. 2019 Jan;85(2):134-145
pubmed: 30297878
Front Genet. 2013 Dec 12;4:277
pubmed: 24376456
Gene. 2018 Nov 30;677:324-331
pubmed: 30130595
Dev Psychol. 2000 Nov;36(6):793-807
pubmed: 11081702
Transl Psychiatry. 2019 Jan 31;9(1):47
pubmed: 30705257
Dev Psychopathol. 2012 Nov;24(4):1361-76
pubmed: 23062303
Clin Epigenetics. 2019 Mar 29;11(1):56
pubmed: 30925934
Nucleic Acids Res. 2017 Jan 4;45(D1):D896-D901
pubmed: 27899670
Nat Genet. 2018 Aug;50(8):1112-1121
pubmed: 30038396
Child Dev. 2016 Jan-Feb;87(1):73-85
pubmed: 26822444
Epigenomics. 2017 Mar;9(3):313-332
pubmed: 28140666
Pediatr Clin North Am. 2009 Jun;56(3):631-46, Table of Contents
pubmed: 19501696
Child Dev. 2016 Jan-Feb;87(1):29-37
pubmed: 26822440
Bioinformatics. 2016 Jan 15;32(2):286-8
pubmed: 26424855
Pediatrics. 2009 Aug;124(2):717-28
pubmed: 19651588
Transl Psychiatry. 2015 Sep 08;5:e633
pubmed: 26348319
Epigenetics. 2012 Apr;7(4):409-14
pubmed: 22419064
J Allergy Clin Immunol. 2020 Feb;145(2):537-549
pubmed: 31669095
World J Psychiatry. 2017 Sep 22;7(3):159-162
pubmed: 29043153
Dev Psychopathol. 2018 Aug;30(3):807-824
pubmed: 30068415
Am J Phys Anthropol. 2014 Oct;155(2):200-9
pubmed: 25043696
J Biol Chem. 2006 Nov 24;281(47):35633-48
pubmed: 16984923
J Gen Intern Med. 2001 Sep;16(9):606-13
pubmed: 11556941
Pediatr Res. 2011 May;69(5 Pt 2):11R-8R
pubmed: 21289534
Epigenomics. 2018 Jul;10(7):925-940
pubmed: 29693419
Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):23996-24005
pubmed: 31611411
J Dev Behav Pediatr. 2019 Apr;40(3):200-207
pubmed: 30801416
Am J Hum Genet. 2020 Mar 5;106(3):389-404
pubmed: 32109421
Genome Biol. 2014 Feb 04;15(2):R31
pubmed: 24495553
BMC Genomics. 2013 May 01;14:293
pubmed: 23631413
Psychol Bull. 2013 Nov;139(6):1342-96
pubmed: 23566018
Am J Psychiatry. 2012 Dec;169(12):1309-17
pubmed: 23212062
Transl Pediatr. 2020 Feb;9(Suppl 1):S3-S8
pubmed: 32206579
Hum Mol Genet. 2017 Oct 15;26(20):4067-4085
pubmed: 29016858