A systematic review on exercise and training-based interventions for freezing of gait in Parkinson's disease.
Journal
NPJ Parkinson's disease
ISSN: 2373-8057
Titre abrégé: NPJ Parkinsons Dis
Pays: United States
ID NLM: 101675390
Informations de publication
Date de publication:
10 Sep 2021
10 Sep 2021
Historique:
received:
01
01
2021
accepted:
12
08
2021
entrez:
11
9
2021
pubmed:
12
9
2021
medline:
12
9
2021
Statut:
epublish
Résumé
Freezing of gait (FOG) in Parkinson's disease (PD) causes severe patient burden despite pharmacological management. Exercise and training are therefore advocated as important adjunct therapies. In this meta-analysis, we assess the existing evidence for such interventions to reduce FOG, and further examine which type of training helps the restoration of gait function in particular. The primary meta-analysis across 41 studies and 1838 patients revealed a favorable moderate effect size (ES = -0.37) of various training modalities for reducing subjective FOG-severity (p < 0.00001), though several interventions were not directly aimed at FOG and some included non-freezers. However, exercise and training also proved beneficial in a secondary analysis on freezers only (ES = -0.32, p = 0.007). We further revealed that dedicated training aimed at reducing FOG episodes (ES = -0.24) or ameliorating the underlying correlates of FOG (ES = -0.40) was moderately effective (p < 0.01), while generic exercises were not (ES = -0.14, p = 0.12). Relevantly, no retention effects were seen after cessation of training (ES = -0.08, p = 0.36). This review thereby supports the implementation of targeted training as a treatment for FOG with the need for long-term engagement.
Identifiants
pubmed: 34508083
doi: 10.1038/s41531-021-00224-4
pii: 10.1038/s41531-021-00224-4
pmc: PMC8433229
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
81Subventions
Organisme : Michael J. Fox Foundation for Parkinson's Research (Michael J. Fox Foundation)
ID : 16347
Organisme : Michael J. Fox Foundation for Parkinson's Research (Michael J. Fox Foundation)
ID : 16347
Organisme : Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders)
ID : 11B5421N
Informations de copyright
© 2021. The Author(s).
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