The gut microbiome in konzo.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
10 09 2021
10 09 2021
Historique:
received:
01
09
2020
accepted:
24
08
2021
entrez:
11
9
2021
pubmed:
12
9
2021
medline:
15
10
2021
Statut:
epublish
Résumé
Konzo, a distinct upper motor neuron disease associated with a cyanogenic diet and chronic malnutrition, predominately affects children and women of childbearing age in sub-Saharan Africa. While the exact biological mechanisms that cause this disease have largely remained elusive, host-genetics and environmental components such as the gut microbiome have been implicated. Using a large study population of 180 individuals from the Democratic Republic of the Congo, where konzo is most frequent, we investigate how the structure of the gut microbiome varied across geographical contexts, as well as provide the first insight into the gut flora of children affected with this debilitating disease using shotgun metagenomic sequencing. Our findings indicate that the gut microbiome structure is highly variable depending on region of sampling, but most interestingly, we identify unique enrichments of bacterial species and functional pathways that potentially modulate the susceptibility of konzo in prone regions of the Congo.
Identifiants
pubmed: 34508085
doi: 10.1038/s41467-021-25694-1
pii: 10.1038/s41467-021-25694-1
pmc: PMC8433213
doi:
Substances chimiques
Nitriles
0
linamarin
H3V9RP3WLO
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5371Subventions
Organisme : FIC NIH HHS
ID : D43 TW009343
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES019841
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM128716
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021. The Author(s).
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