Subtyping Schizophrenia Patients Based on Patterns of Structural Brain Alterations.
Schizophrenia
brain alterations
heterogeneity
neuroimaging
structural MRI
subgroup
Journal
Schizophrenia bulletin
ISSN: 1745-1701
Titre abrégé: Schizophr Bull
Pays: United States
ID NLM: 0236760
Informations de publication
Date de publication:
21 01 2022
21 01 2022
Historique:
pubmed:
12
9
2021
medline:
3
3
2022
entrez:
11
9
2021
Statut:
ppublish
Résumé
Schizophrenia is a complex and heterogeneous syndrome. Whether quantitative imaging biomarkers can identify discrete subgroups of patients as might be used to foster personalized medicine approaches for patient care remains unclear. Cross-sectional structural MR images of 163 never-treated first-episode schizophrenia patients (FES) and 133 chronically ill patients with midcourse schizophrenia from the Bipolar and Schizophrenia Network for Intermediate Phenotypes (B-SNIP) consortium and a total of 403 healthy controls were recruited. Morphometric measures (cortical thickness, surface area, and subcortical structures) were extracted for each subject and then the optimized subtyping results were obtained with nonsupervised cluster analysis. Three subgroups of patients defined by distinct patterns of regional cortical and subcortical morphometric features were identified in FES. A similar three subgroup pattern was identified in the independent dataset of patients from the multi-site B-SNIP consortium. Similarities of classification patterns across these two patient cohorts suggest that the 3-group typology is relatively stable over the course of illness. Cognitive functions were worse in subgroup 1 with midcourse schizophrenia than those in subgroup 3. These findings provide novel insight into distinct subgroups of patients with schizophrenia based on structural brain features. Findings of different cognitive functions among the subgroups support clinical differences in the MRI-defined illness subtypes. Regardless of clinical presentation and stage of illness, anatomic MR subgrouping biomarkers can separate neurobiologically distinct subgroups of schizophrenia patients, which represent an important and meaningful step forward in differentiating subtypes of patients for studies of illness neurobiology and potentially for clinical trials.
Identifiants
pubmed: 34508358
pii: 6368514
doi: 10.1093/schbul/sbab110
pmc: PMC8781382
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
241-250Subventions
Organisme : NIMH NIH HHS
ID : R01 MH077852
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.
Références
Dis Markers. 2013;35(1):3-9
pubmed: 24167344
Schizophr Bull. 2015 Nov;41(6):1224-6
pubmed: 26333841
Schizophr Bull. 2018 Jan 13;44(1):101-113
pubmed: 28369611
Am J Psychiatry. 2020 Apr 1;177(4):298-307
pubmed: 31838871
Biol Psychiatry. 2017 Jul 1;82(1):26-39
pubmed: 27817844
Radiology. 2016 Nov;281(2):357-372
pubmed: 27755933
Am J Med Genet B Neuropsychiatr Genet. 2017 Oct;174(7):757-764
pubmed: 28786528
Neuropsychopharmacology. 2007 Jun;32(6):1216-23
pubmed: 17063154
Nat Med. 2017 Jan;23(1):28-38
pubmed: 27918562
Am J Med Genet B Neuropsychiatr Genet. 2013 Oct;162B(7):648-52
pubmed: 24132896
Int J Bipolar Disord. 2018 Jul 11;6(1):16
pubmed: 29992455
Mol Psychiatry. 2020 Oct;25(10):2431-2440
pubmed: 30410064
Arch Gen Psychiatry. 2010 Aug;67(8):783-92
pubmed: 20679586
Behav Brain Funct. 2011 Oct 07;7:43
pubmed: 21981786
Lancet. 1994 Nov 19;344(8934):1434
pubmed: 7968091
JAMA Psychiatry. 2019 Jul 1;76(7):739-748
pubmed: 30969333
JAMA Psychiatry. 2015 Mar;72(3):226-34
pubmed: 25588194
J Psychiatr Res. 2017 Oct;93:37-49
pubmed: 28578207
Biol Psychiatry. 2014 Jul 15;76(2):111-9
pubmed: 24094513
Eur Neuropsychopharmacol. 2016 Jun;26(6):923-37
pubmed: 27005595
Am J Psychiatry. 2013 Nov;170(11):1308-16
pubmed: 23732942
Front Syst Neurosci. 2017 Apr 27;11:25
pubmed: 28496402
Neurosci Biobehav Rev. 2013 Sep;37(8):1680-91
pubmed: 23769814
JAMA Psychiatry. 2016 Dec 1;73(12):1251-1259
pubmed: 27829096
J Psychiatr Res. 2018 Feb;97:8-15
pubmed: 29156414
JAMA Psychiatry. 2013 May;70(5):481-9
pubmed: 23467813
Mol Psychiatry. 2016 Apr;21(4):547-53
pubmed: 26033243
Front Psychiatry. 2019 Jan 30;9:757
pubmed: 30761026
Brain. 2020 Mar 1;143(3):1027-1038
pubmed: 32103250
Schizophr Res. 2019 Dec;214:11-17
pubmed: 29208422
Front Mol Neurosci. 2018 Jun 11;11:192
pubmed: 29942251
Science. 2014 Jun 27;344(6191):1492-6
pubmed: 24970081
Psychiatry Res. 2012 Aug 15;198(3):386-94
pubmed: 22424892
Mol Psychiatry. 2018 May;23(5):1261-1269
pubmed: 29038599
Am J Psychiatry. 2016 Apr 1;173(4):373-84
pubmed: 26651391
Hum Genet. 2017 Feb;136(2):263-274
pubmed: 28035465
Biomark Med. 2014;8(1):51-7
pubmed: 24325224
Schizophr Bull. 2015 Jan;41(1):201-10
pubmed: 24353097
Schizophr Bull. 2018 Aug 20;44(5):1053-1059
pubmed: 29471434
Neuropsychopharmacology. 2005 Sep;30(9):1649-61
pubmed: 15756305
Neuropsychobiology. 2012;66(1):44-9
pubmed: 22797276
Schizophr Res. 2019 Feb;204:238-244
pubmed: 30177343
Am J Psychiatry. 2013 Nov;170(11):1275-84
pubmed: 23771174
Prog Neurobiol. 2017 May;152:3-20
pubmed: 27519538
Biol Psychiatry. 2012 Mar 15;71(6):552-60
pubmed: 22281121
Arch Gen Psychiatry. 2011 Feb;68(2):128-37
pubmed: 21300943
J Nerv Ment Dis. 2013 Sep;201(9):744-52
pubmed: 23995029
Mol Psychiatry. 2020 Apr;25(4):863-872
pubmed: 30283030
Nat Neurosci. 2017 Feb 23;20(3):314-326
pubmed: 28230838
Aust N Z J Psychiatry. 2017 May;51(5):500-508
pubmed: 28415873
Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Nov;1(6):488-497
pubmed: 29653095
Neuropsychol Rev. 2001 Mar;11(1):45-67
pubmed: 11392562
Schizophr Res. 2019 Dec;214:43-50
pubmed: 29274735
Am J Psychiatry. 2017 Mar 1;174(3):286-295
pubmed: 27919183
Am J Psychiatry. 2013 Nov;170(11):1263-74
pubmed: 23846857
Arch Gen Psychiatry. 2006 Nov;63(11):1189-97
pubmed: 17088499
Schizophr Bull. 2020 Apr 10;46(3):623-632
pubmed: 31901940
Schizophr Res. 2019 Dec;214:60-69
pubmed: 29807804
Dialogues Clin Neurosci. 2014 Dec;16(4):491-503
pubmed: 25733954
Eur Arch Psychiatry Clin Neurosci. 2013 Feb;263(1):25-39
pubmed: 22610045
Biochem Pharmacol. 2017 Nov 1;143:10-24
pubmed: 28522405