Deletion of the sodium/hydrogen exchanger 6 causes low bone volume in adult mice.

Animals Hydrogen Mice Mice, Knockout Osteoblasts Osteoclasts Sodium Sodium-Hydrogen Exchangers / genetics X-Ray Microtomography
Bone formation Bone histomorphometry Bone μCT Osteoblasts Osteoclasts Osteocytes Sclerostin

Journal

Bone
ISSN: 1873-2763
Titre abrégé: Bone
Pays: United States
ID NLM: 8504048

Informations de publication

Date de publication:
12 2021
Historique:
received: 06 04 2021
revised: 04 09 2021
accepted: 05 09 2021
pubmed: 12 9 2021
medline: 26 10 2021
entrez: 11 9 2021
Statut: ppublish

Résumé

The sodium/hydrogen exchanger 6 (NHE6) localizes to recycling endosomes, where it mediates endosomal alkalinization through K

Identifiants

DOI: 10.1016/j.bone.2021.116178 PMID: 34508879
pubmed: 34508879
pii: S8756-3282(21)00344-6
doi: 10.1016/j.bone.2021.116178
pii:
doi:

Substances chimiques

NHE6 protein, mouse 0
Sodium-Hydrogen Exchangers 0
Hydrogen 7YNJ3PO35Z
Sodium 9NEZ333N27

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

116178

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.

Auteurs

Daniela Schnyder (D)

Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; National Centre of Competence in Research (NCCR) TransCure, University of Bern, Bern, Switzerland; Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.

Giuseppe Albano (G)

Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; National Centre of Competence in Research (NCCR) TransCure, University of Bern, Bern, Switzerland; Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.

Patrycja Kucharczyk (P)

Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; National Centre of Competence in Research (NCCR) TransCure, University of Bern, Bern, Switzerland; Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.

Silvia Dolder (S)

National Centre of Competence in Research (NCCR) TransCure, University of Bern, Bern, Switzerland; Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.

Mark Siegrist (M)

National Centre of Competence in Research (NCCR) TransCure, University of Bern, Bern, Switzerland; Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.

Manuel Anderegg (M)

Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; National Centre of Competence in Research (NCCR) TransCure, University of Bern, Bern, Switzerland; Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.

Ganesh Pathare (G)

Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; National Centre of Competence in Research (NCCR) TransCure, University of Bern, Bern, Switzerland; Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.

Willy Hofstetter (W)

National Centre of Competence in Research (NCCR) TransCure, University of Bern, Bern, Switzerland; Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.

Roland Baron (R)

Division of Bone and Mineral Research, Harvard Medical School and Harvard School of Dental Medicine, Boston, MA, USA; Department of Oral Medicine, Infection and Immunity, Harvard Medical School and Harvard School of Dental Medicine, Boston, MA, USA.

Daniel G Fuster (DG)

Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; National Centre of Competence in Research (NCCR) TransCure, University of Bern, Bern, Switzerland; Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland. Electronic address: Daniel.Fuster@dbmr.unibe.ch.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Deletion of the sodium/hydrogen exchanger 6...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Hydrogène › Deletion of the sodium/hydrogen exchanger 6...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Deletion of the sodium/hydrogen exchanger 6...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Deletion of the sodium/hydrogen exchanger 6...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Ostéoblastes › Deletion of the sodium/hydrogen exchanger 6...
questionsmedicales.fr › Cellules › Cellules myéloïdes › Ostéoclastes › Deletion of the sodium/hydrogen exchanger 6...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Sodium › Deletion of the sodium/hydrogen exchanger 6...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Antiport des ions sodium-hydrogène › Deletion of the sodium/hydrogen exchanger 6...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › Microtomographie aux rayons X › Deletion of the sodium/hydrogen exchanger 6...