Autoimmunity roots of the thrombotic events after COVID-19 vaccination.
Adenoviral vector-based vaccine
Autoimmune reaction
COVID-19
Lipid nanoparticle-mRNA-based vaccine
Vaccine-induced immune thrombotic thrombocytopenia
Journal
Autoimmunity reviews
ISSN: 1873-0183
Titre abrégé: Autoimmun Rev
Pays: Netherlands
ID NLM: 101128967
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
29
05
2021
accepted:
06
06
2021
pubmed:
12
9
2021
medline:
21
10
2021
entrez:
11
9
2021
Statut:
ppublish
Résumé
Although vaccination represents the most promising way to stop or contain the coronavirus disease 2019 (COVID-19) pandemic and safety and effectiveness of available vaccines were proven, a small number of individuals who received anti-SARS-CoV-2 vaccines developed a prothrombotic syndrome. Vaccine-induced immune thrombotic thrombocytopenia (VITT) can be triggered by the adenoviral vector-based vaccine, whereas lipid nanoparticle-mRNA-based vaccines can induce rare cases of deep vein thrombosis (DVT). Although the main pathogenic mechanisms behind this rare phenomenon have not yet been identified, both host and vaccine factors might be involved, with pathology at least in part being related to the vaccine-triggered autoimmune reaction. In this review, we are considering some aspects related to pathogenesis, major risk factors, as well as peculiarities of diagnosis and treatment of this rare condition.
Identifiants
pubmed: 34508917
pii: S1568-9972(21)00216-0
doi: 10.1016/j.autrev.2021.102941
pmc: PMC8426137
pii:
doi:
Substances chimiques
COVID-19 Vaccines
0
Viral Vaccines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102941Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
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