Cerebral hemodynamics and capillary dysfunction in late-onset major depressive disorder.
Capillary dysfunction
Capillary transit time heterogeneity (CTH)
Cerebral blood flow (CBF)
Cerebral blood volume (CBV)
Default mode network (DMN)
Magnetic resonance imaging (MRI)
Major depressive disorder (MDD)
Neurovascular coupling
Relative transit time heterogeneity (RTH)
Journal
Psychiatry research. Neuroimaging
ISSN: 1872-7506
Titre abrégé: Psychiatry Res Neuroimaging
Pays: Netherlands
ID NLM: 101723001
Informations de publication
Date de publication:
30 11 2021
30 11 2021
Historique:
received:
06
03
2021
revised:
22
08
2021
accepted:
31
08
2021
pubmed:
12
9
2021
medline:
29
3
2022
entrez:
11
9
2021
Statut:
ppublish
Résumé
In major depressive disorder (MDD), perfusion changes in cortico-limbic pathways are interpreted as altered neuronal activity, but they could also signify changes in neurovascular coupling due to altered capillary function. To examine capillary function in late-onset MDD, 22 patients and 22 age- and gender-matched controls underwent perfusion MRI. We measured normalized cerebral blood flow (nCBF), cerebral blood volume (nCBV), and relative transit-time heterogeneity (RTH). Resulting brain oxygenation was estimated in terms of oxygen tension and normalized metabolic rate of oxygen (nCMRO
Identifiants
pubmed: 34508953
pii: S0925-4927(21)00135-9
doi: 10.1016/j.pscychresns.2021.111383
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111383Informations de copyright
Copyright © 2021. Published by Elsevier B.V.