Monitoring the cellular metabolism of a membrane-permeant photo-caged phosphatidylinositol 3,4,5-trisphosphate derivative.
Mass spectrometry
Multi-reaction monitoring
Phosphoinositides
Photoactivatable groups
Protecting groups
Journal
Chemistry and physics of lipids
ISSN: 1873-2941
Titre abrégé: Chem Phys Lipids
Pays: Ireland
ID NLM: 0067206
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
02
06
2021
revised:
22
07
2021
accepted:
13
08
2021
pubmed:
13
9
2021
medline:
28
12
2021
entrez:
12
9
2021
Statut:
ppublish
Résumé
To deliver charged lipid derivatives to the cell interior, bioactivatable and photo-activatable protecting groups are frequently used. The intracellular metabolism of the protecting groups, as well as the lipid itself, are key factors that determine biological activity. Here we followed the cellular metabolism of cell-permeant photo-activatable ("caged") and non-caged membrane-permeant analogs of dioctanoyl phosphatidylinositol 3,4,5-trisphosphate (diC
Identifiants
pubmed: 34509466
pii: S0009-3084(21)00077-3
doi: 10.1016/j.chemphyslip.2021.105124
pii:
doi:
Substances chimiques
Phosphatidylinositol Phosphates
0
phosphatidylinositol 3,4,5-triphosphate
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105124Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM127631
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.