A comprehensive review on the lipid and pleiotropic effects of pitavastatin.

Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology Hypercholesterolemia Lipids Quinolines / pharmacology
Hypercholesterolemia Inflammation Pitavastatin Pleiotropic effects Statin

Journal

Progress in lipid research
ISSN: 1873-2194
Titre abrégé: Prog Lipid Res
Pays: England
ID NLM: 7900832

Informations de publication

Date de publication:
11 2021
Historique:
received: 27 06 2021
revised: 31 08 2021
accepted: 06 09 2021
pubmed: 13 9 2021
medline: 29 1 2022
entrez: 12 9 2021
Statut: ppublish

Résumé

The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, or statins, are administered as first line therapy for hypercholesterolemia, both in primary and secondary prevention. There is a growing body of evidence showing that beyond their lipid-lowering effect, statins have a number of additional beneficial properties. Pitavastatin is a unique lipophilic statin with a strong effect on lowering plasma total cholesterol and triacylglycerol. It has been reported to have pleiotropic effects such as decreasing inflammation and oxidative stress, regulating angiogenesis and osteogenesis, improving endothelial function and arterial stiffness, and reducing tumor progression. Based on the available studies considering the risk of statin-associated muscle symptoms it seems to be also the safest statin. The unique lipid and non-lipid effects of pitavastatin make this molecule a particularly interesting option for the management of different human diseases. In this review, we first summarized the lipid effects of pitavastatin and then strive to unravel the diverse pleiotropic effects of this molecule.

Identifiants

DOI: 10.1016/j.plipres.2021.101127 PMID: 34509516
pubmed: 34509516
pii: S0163-7827(21)00043-6
doi: 10.1016/j.plipres.2021.101127
pii:
doi:

Substances chimiques

Hydroxymethylglutaryl-CoA Reductase Inhibitors 0
Lipids 0
Quinolines 0
pitavastatin M5681Q5F9P

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

101127

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Amirhossein Sahebkar (A)

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Medicine, The University of Western Australia, Perth, Australia; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: sahebkara@mums.ac.ir.

Nasim Kiaie (N)

Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

Armita Mahdavi Gorabi (AM)

Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

Massimo R Mannarino (MR)

Unit of Internal Medicine, Department of Medicine, University of Perugia, Perugia, Italy.

Vanessa Bianconi (V)

Unit of Internal Medicine, Department of Medicine, University of Perugia, Perugia, Italy.

Tannaz Jamialahmadi (T)

Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Iran; Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Matteo Pirro (M)

Unit of Internal Medicine, Department of Medicine, University of Perugia, Perugia, Italy.

Maciej Banach (M)

Department of Preventive Cardiology and Lipidology, Medical University of Lodz (MUL), Lodz, Poland; Cardiovascular Research Centre, University of Zielona Gora, Zielona-Gora, Poland. Electronic address: maciej.banach@umed.lodz.pl.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A comprehensive review on the lipid and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents régulateurs du métabolisme des lipides › Hypolipémiants › Anticholestérolémiants › Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase › A comprehensive review on the lipid and...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme lipidique › Dyslipidémies › Hyperlipidémies › Hypercholestérolémie › A comprehensive review on the lipid and...
questionsmedicales.fr › Lipides › A comprehensive review on the lipid and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › A comprehensive review on the lipid and...