Pattern recognition receptor expression and maturation profile of dendritic cell subtypes in human tonsils and lymph nodes.
Adolescent
Adult
Aged
Aged, 80 and over
B7-1 Antigen
/ metabolism
B7-2 Antigen
/ metabolism
CD40 Antigens
/ metabolism
Dendritic Cells
/ cytology
Female
Humans
Lymph Nodes
/ cytology
Male
Middle Aged
Palatine Tonsil
/ cytology
Receptors, G-Protein-Coupled
/ metabolism
Receptors, Pattern Recognition
/ metabolism
Young Adult
Cancer
Dendritic cell
Immunotherapy
PRR
Vaccination
Journal
Human immunology
ISSN: 1879-1166
Titre abrégé: Hum Immunol
Pays: United States
ID NLM: 8010936
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
18
03
2021
revised:
18
07
2021
accepted:
10
08
2021
pubmed:
14
9
2021
medline:
3
3
2022
entrez:
13
9
2021
Statut:
ppublish
Résumé
Dendritic cells (DCs) with capacity of antigen cross-presentation are of key interest for immunotherapy against cancer as they can induce antigen-specific cytotoxic T lymphocyte (CTL) responses. This study describes frequencies of DC subtypes in human tonsils and lymph nodes, and phenotypic aspects that may be targeted by adjuvant measures. From human tonsils and neck lymph nodes, DCs were identified through flow cytometry, and subsets of plasmacytoid DCs (pDCs) and myeloid DCs (mDCs) were investigated. Maturity status was assessed and surface receptors with CTL-promoting potentials were studied. CD123
Identifiants
pubmed: 34511272
pii: S0198-8859(21)00206-8
doi: 10.1016/j.humimm.2021.08.007
pii:
doi:
Substances chimiques
B7-1 Antigen
0
B7-2 Antigen
0
CD40 Antigens
0
CD80 protein, human
0
CD86 protein, human
0
Receptors, G-Protein-Coupled
0
Receptors, Pattern Recognition
0
XCR1 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
976-981Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.