Elemene Nanoemulsion Inhibits Metastasis of Breast Cancer by ROS Scavenging.
ROS
breast cancer
elemene
macrophages
tumor microenvironment
Journal
International journal of nanomedicine
ISSN: 1178-2013
Titre abrégé: Int J Nanomedicine
Pays: New Zealand
ID NLM: 101263847
Informations de publication
Date de publication:
2021
2021
Historique:
received:
02
07
2021
accepted:
19
08
2021
entrez:
13
9
2021
pubmed:
14
9
2021
medline:
25
11
2021
Statut:
epublish
Résumé
Elemene (C The ESR measurement and quantum mechanics simulation were used to characterize the antioxidant ability of elemene nanoemulsion. The murine breast cancer cell line 4T1 cells were inoculated subcutaneously into the left fourth mammary fat pad of BalB/c mice to establish a TNBC mice model. The H&E staining, immunohistochemical staining, DHE staining and Western blot were employed to evaluate the therapeutic effects of the elemene nanoemulsion on the TNBC mice. It was shown that the elemene nanoemulsion prolonged the survival of the triple-negative breast cancer-bearing mice and inhibited the metastasis to lung and liver while did not induce significant cytotoxicity to the tumor cells. Mechanistic studies demonstrated that the elemene nanoemulsion effectively scavenged the reactive oxygen species (ROS) in vitro and in vivo, which decreased the stabilization of hypoxia-inducible factor-1α (HIF-1α) and consequently reduced angiogenesis in the tumor microenvironment as well as decreased the level of NLRP3 inflammasomes and IL-1β production. In addition, the elemene nanoemulsion downregulated the level of IL-1β in the RAW264.7 cells in exposure with LPS. In conclusion, due to the ROS scavenging ability, elemene nanoemulsion effectively inhibited the metastasis of the breast cancer cells to lung and liver and consequently prolonged the survival of TNBC mice.
Identifiants
pubmed: 34511904
doi: 10.2147/IJN.S327094
pii: 327094
pmc: PMC8418379
doi:
Substances chimiques
Reactive Oxygen Species
0
Sesquiterpenes
0
elemene
11029-06-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6035-6048Informations de copyright
© 2021 Han et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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