Prevention and Treatment of Hardware-Related Infections in Deep Brain Stimulation Surgeries: A Retrospective and Historical Controlled Study.
deep brain stimulation
hardware-related complication
implantable pulse generator
infection
treatment of infection
Journal
Frontiers in human neuroscience
ISSN: 1662-5161
Titre abrégé: Front Hum Neurosci
Pays: Switzerland
ID NLM: 101477954
Informations de publication
Date de publication:
2021
2021
Historique:
received:
10
05
2021
accepted:
02
08
2021
entrez:
13
9
2021
pubmed:
14
9
2021
medline:
14
9
2021
Statut:
epublish
Résumé
Hardware-related infection in deep brain stimulation (DBS) is one of the most commonly reported complications frequently resulting in the removal of implantable pulse generator (IPG). The aim of this study was to establish a useful strategy to better prevent and treat those infections and to improve the preservation rates of IPG. We conducted a retrospective and historical controlled study of all adult patients (≥18 years old) who had undergone initial DBS implantation at a single center. All participants were enrolled in the control group (between June 2005 and June 2014) or intervention group (between July 2014 and May 2019) based on their surgery dates. We used the intraoperative irrigation with hydrogen dioxide solution in the intervention group. Based on the dates of diagnosis, patients with hardware-related infection after DBS were enrolled in group A (between June 2005 and June 2014) or group B (between July 2014 and May 2019). IPG-sparing algorithm (Isa) was applied for group B. The early-onset IPG infections of the control and intervention groups were evaluated. The IPG preservation rates in both groups A and B were statistically analyzed. Six cases of early IPG infection and subsequent IPG removal occurred in the control group, while none occurred after intraoperative usage of the hydrogen dioxide in the intervention group. IPG preservation rate of infected cases in group B was significantly higher than that in group A (70% vs.16%, The combined application of hydrogen dioxide solution and Isa seems to be an effective strategy to prevent IPG infection.
Sections du résumé
BACKGROUND
BACKGROUND
Hardware-related infection in deep brain stimulation (DBS) is one of the most commonly reported complications frequently resulting in the removal of implantable pulse generator (IPG).
OBJECTIVE
OBJECTIVE
The aim of this study was to establish a useful strategy to better prevent and treat those infections and to improve the preservation rates of IPG.
METHODS
METHODS
We conducted a retrospective and historical controlled study of all adult patients (≥18 years old) who had undergone initial DBS implantation at a single center. All participants were enrolled in the control group (between June 2005 and June 2014) or intervention group (between July 2014 and May 2019) based on their surgery dates. We used the intraoperative irrigation with hydrogen dioxide solution in the intervention group. Based on the dates of diagnosis, patients with hardware-related infection after DBS were enrolled in group A (between June 2005 and June 2014) or group B (between July 2014 and May 2019). IPG-sparing algorithm (Isa) was applied for group B. The early-onset IPG infections of the control and intervention groups were evaluated. The IPG preservation rates in both groups A and B were statistically analyzed.
RESULTS
RESULTS
Six cases of early IPG infection and subsequent IPG removal occurred in the control group, while none occurred after intraoperative usage of the hydrogen dioxide in the intervention group. IPG preservation rate of infected cases in group B was significantly higher than that in group A (70% vs.16%,
CONCLUSION
CONCLUSIONS
The combined application of hydrogen dioxide solution and Isa seems to be an effective strategy to prevent IPG infection.
Identifiants
pubmed: 34512294
doi: 10.3389/fnhum.2021.707816
pmc: PMC8427065
doi:
Types de publication
Journal Article
Langues
eng
Pagination
707816Informations de copyright
Copyright © 2021 Li, Zhang, Mei, Qiao, Wang, Zhang, Li, Hu, Jia and Zhang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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