A Retrospective Clinical Analysis of the Serum Bile Acid Alteration Caused by Traumatic Brain Injury.
bile acid
brain-gut axis
gut microbiota
retrospective study
traumatic brain injury
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2021
2021
Historique:
received:
02
11
2020
accepted:
09
07
2021
entrez:
13
9
2021
pubmed:
14
9
2021
medline:
14
9
2021
Statut:
epublish
Résumé
Traumatic brain injury (TBI) can cause damage to peripheral organ systems, such as digestive organ system, and alterations of gut microbiota in addition to brain injury. Our previous study found that TBI induced gastrointestinal dysfunction accompanied by alterations of bile acid metabolism. Bile acid and its receptors have been reported to play important roles in various neurological diseases. To further examine the changes of bile acid metabolism in TBI patients, we performed a retrospective clinical analysis. In this study, 177 patients were included, and the results showed that TBI patients had more frequent antibiotic use compared with a control group. Regression analysis identified TBI as an independent factor for reduction of serum bile acid level (B = -1.762,
Identifiants
pubmed: 34512494
doi: 10.3389/fneur.2021.624378
pmc: PMC8424180
doi:
Types de publication
Journal Article
Langues
eng
Pagination
624378Informations de copyright
Copyright © 2021 Zhu, Chen, You, Wang, Tu, Zheng, Wen and Yang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Neurotrauma. 2009 Aug;26(8):1353-9
pubmed: 19344293
Annu Rev Biochem. 2003;72:137-74
pubmed: 12543708
Neurogastroenterol Motil. 2013 Jul;25(7):593-e463
pubmed: 23551971
Neurol Sci. 2019 Jun;40(6):1105-1110
pubmed: 30771023
Curr Opin Lipidol. 2019 Jun;30(3):244-254
pubmed: 30893108
Mayo Clin Proc. 2013 Oct;88(10):1091-8
pubmed: 24012412
Proc Natl Acad Sci U S A. 2003 May 13;100(10):6087-92
pubmed: 12721362
J Neuroinflammation. 2021 Feb 2;18(1):40
pubmed: 33531049
Am J Surg. 2007 Nov;194(5):623-7
pubmed: 17936424
Gut Microbes. 2020;11(2):158-171
pubmed: 31595814
Free Radic Biol Med. 2019 Nov 1;143:441-453
pubmed: 31493504
Sci Rep. 2017 Jan 20;7:40112
pubmed: 28106051
J Neurotrauma. 2021 Apr 14;:
pubmed: 33677989
Nature. 2019 Oct;574(7779):543-548
pubmed: 31645720
Toxicol Appl Pharmacol. 2019 Jan 15;363:79-87
pubmed: 30502395
Front Cell Neurosci. 2017 Jul 06;11:193
pubmed: 28729823
Brain Behav Immun. 2017 Nov;66:56-69
pubmed: 28676351
Curr Med Chem. 2018;25(30):3613-3636
pubmed: 29521205
Front Immunol. 2018 Nov 27;9:2757
pubmed: 30546361
Front Endocrinol (Lausanne). 2019 Jun 26;10:386
pubmed: 31297087
Brain Behav Immun. 2017 Nov;66:31-44
pubmed: 28526435
Atherosclerosis. 2020 Jan;293:79-85
pubmed: 31869574
Br J Surg. 2019 Aug;106(9):1178-1186
pubmed: 31216062
Front Physiol. 2018 Oct 31;9:1534
pubmed: 30429801
J Cell Physiol. 2017 Aug;232(8):2231-2245
pubmed: 27987324
Neurocrit Care. 2016 Aug;25(1):153-66
pubmed: 26759227
Nat Rev Gastroenterol Hepatol. 2019 Apr;16(4):235-246
pubmed: 30643227
Nat Rev Gastroenterol Hepatol. 2018 Feb;15(2):111-128
pubmed: 29018272
N Engl J Med. 1994 Feb 10;330(6):377-81
pubmed: 8284001
Pharmacol Res. 2018 Jul;133:170-186
pubmed: 29660405
J Neurotrauma. 2018 Sep 1;35(17):2067-2076
pubmed: 29648974
J Cereb Blood Flow Metab. 2002 Apr;22(4):463-71
pubmed: 11919517
Neurosurgery. 2017 Jan 01;80(1):6-15
pubmed: 27654000