The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-Analysis.
Trp64Arg
insulin resistance
meta-analysis
subgroup analysis
β3-adrenergic receptor gene
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2021
2021
Historique:
received:
11
05
2021
accepted:
27
07
2021
entrez:
13
9
2021
pubmed:
14
9
2021
medline:
11
2
2022
Statut:
epublish
Résumé
Insulin resistance is a metabolic disorder that occurs in type 2 diabetes mellitus and obesity. Genetic factors such as β3-adrenoceptor polymorphism (Trp64Arg) may be involved in IR and insulin secretion. However, their association is controversial. Therefore, the current meta-analysis was conducted to clarify the relationship between the Trp64Arg and IR. The literature search was performed in PubMed, Embase, and Web of Science using the keywords "Receptors, Adrenergic, beta-3, Receptors, Adrenergic, Insulin Resistance, Protein-Coupled Receptor Kinase 3" from 2005 to February 7, 2021. We used a random-effects model to calculate the pooled effect size. We conducted subgroup analysis and regression analysis to identify sources of heterogeneity; and Egger's test and funnel plot were used to test publication bias. Finally, we conducted a sensitivity analysis. We included eight papers with 1,586 subjects. There was a positive correlation between Trp64Arg mutation and insulin level (standardized mean difference = 0.20, 95% confidence intervals: 0.00 to 0.39, Trp64Arg may be associated with IR. European ancestry, obesity, plasma insulin level, and test status may be potential factors affecting the relationship between Trp64Arg and IR.
Sections du résumé
Background
Insulin resistance is a metabolic disorder that occurs in type 2 diabetes mellitus and obesity. Genetic factors such as β3-adrenoceptor polymorphism (Trp64Arg) may be involved in IR and insulin secretion. However, their association is controversial. Therefore, the current meta-analysis was conducted to clarify the relationship between the Trp64Arg and IR.
Methods
The literature search was performed in PubMed, Embase, and Web of Science using the keywords "Receptors, Adrenergic, beta-3, Receptors, Adrenergic, Insulin Resistance, Protein-Coupled Receptor Kinase 3" from 2005 to February 7, 2021. We used a random-effects model to calculate the pooled effect size. We conducted subgroup analysis and regression analysis to identify sources of heterogeneity; and Egger's test and funnel plot were used to test publication bias. Finally, we conducted a sensitivity analysis.
Results
We included eight papers with 1,586 subjects. There was a positive correlation between Trp64Arg mutation and insulin level (standardized mean difference = 0.20, 95% confidence intervals: 0.00 to 0.39,
Conclusion
Trp64Arg may be associated with IR. European ancestry, obesity, plasma insulin level, and test status may be potential factors affecting the relationship between Trp64Arg and IR.
Identifiants
pubmed: 34512548
doi: 10.3389/fendo.2021.708139
pmc: PMC8426512
doi:
Substances chimiques
Receptors, Adrenergic, beta
0
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
708139Informations de copyright
Copyright © 2021 Wang, Zhang, Li, Lin, Zhang, Liu, Ma and Dong.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Ann Lab Med. 2015 May;35(3):283-7
pubmed: 25932435
J Clin Invest. 1989 Jul;84(1):205-13
pubmed: 2661589
Gynecol Endocrinol. 2008 Mar;24(3):133-8
pubmed: 18335327
Adv Data. 2000 Jun 8;(314):1-27
pubmed: 11183293
J Clin Endocrinol Metab. 1996 Nov;81(11):4155-8
pubmed: 8923875
J Clin Endocrinol Metab. 1998 Jul;83(7):2441-4
pubmed: 9661625
Nat Rev Nephrol. 2016 Dec;12(12):721-737
pubmed: 27748389
J Clin Epidemiol. 2009 Oct;62(10):e1-34
pubmed: 19631507
Diabet Med. 1999 Oct;16(10):835-40
pubmed: 10547210
Trends Pharmacol Sci. 1994 Jan;15(1):3-7
pubmed: 8140656
Ann Nutr Metab. 2008;52(4):267-71
pubmed: 18617734
J Biol Chem. 1973 Jan 10;248(1):244-50
pubmed: 4348209
Naunyn Schmiedebergs Arch Pharmacol. 2004 Jan;369(1):1-22
pubmed: 14647973
Stat Med. 2002 Jun 15;21(11):1539-58
pubmed: 12111919
Diabetologia. 2000 Mar;43(3):285-93
pubmed: 10768089
JAMA Intern Med. 2017 Jul 1;177(7):909-910
pubmed: 28542694
Clin Nutr ESPEN. 2019 Oct;33:29-38
pubmed: 31451269
Int J Obes Relat Metab Disord. 1998 Jun;22(6):559-66
pubmed: 9665677
Diabetes. 1996 Aug;45(8):1115-20
pubmed: 8690160
Eur Rev Med Pharmacol Sci. 2012 May;16(5):610-6
pubmed: 22774401
N Engl J Med. 1995 Aug 10;333(6):348-51
pubmed: 7609751
Curr Cardiol Rep. 2016 Aug;18(8):75
pubmed: 27312935
J Pediatr Endocrinol Metab. 2008 Feb;21(2):147-54
pubmed: 18422027
J Pediatr (Rio J). 2018 Jul - Aug;94(4):425-431
pubmed: 28941386
Lancet. 1996 Sep 14;348(9029):698-9
pubmed: 8806286
Obes Res. 2001 Dec;9(12):806-9
pubmed: 11743064
Eur J Clin Nutr. 2005 Aug;59(8):955-9
pubmed: 15942638
Eur Respir J. 2007 Oct;30(4):743-7
pubmed: 17626108
J Clin Endocrinol Metab. 1998 Nov;83(11):4002-5
pubmed: 9814483
Eat Weight Disord. 2018 Apr;23(2):149-157
pubmed: 29397563
Appl Physiol Nutr Metab. 2016 Mar;41(3):307-14
pubmed: 26888112
Cardiovasc Diabetol. 2011 Oct 12;10:89
pubmed: 21992420
N Engl J Med. 1995 Aug 10;333(6):352-4
pubmed: 7609752
Clin Endocrinol (Oxf). 2005 Feb;62(2):126-31
pubmed: 15670186
Int J Epidemiol. 2008 Oct;37(5):1148-57
pubmed: 18424475
Nutr Hosp. 2017 Mar 30;34(2):383-388
pubmed: 28421794
Obes Res. 2005 Oct;13(10):1709-19
pubmed: 16286518
Diabetes Care. 2013 Mar;36(3):648-55
pubmed: 23129134
Obes Res. 2001 Dec;9(12):741-5
pubmed: 11743057
Diabetes Obes Metab. 2006 May;8(3):322-30
pubmed: 16634992
Diabetologia. 2010 Apr;53(4):757-67
pubmed: 20076942
Prog Mol Biol Transl Sci. 2019;161:91-112
pubmed: 30711031
Trends Pharmacol Sci. 1997 Dec;18(12):449-54
pubmed: 9458691
Ann N Y Acad Sci. 2002 Jun;967:329-35
pubmed: 12079860
Prog Mol Biol Transl Sci. 2014;121:267-92
pubmed: 24373240
Nutr Hosp. 2010 Mar-Apr;25(2):299-303
pubmed: 20449541
N Engl J Med. 1995 Aug 10;333(6):343-7
pubmed: 7609750