Childhood Vaccinations and Type 1 Diabetes.
autoimmunity
infection
type 1 diabetes
vaccination
vaccine
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
15
02
2021
accepted:
12
08
2021
entrez:
13
9
2021
pubmed:
14
9
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Type 1 diabetes (T1D) is the most common paediatric endocrine disease, and its frequency has been found to increase worldwide. Similar to all conditions associated with poorly regulated glucose metabolism, T1D carries an increased risk of infection. Consequently, careful compliance by T1D children with schedules officially approved for child immunization is strongly recommended. However, because patients with T1D show persistent and profound limitations in immune function, vaccines may evoke a less efficient immune response, with corresponding lower protection. Moreover, T1D is an autoimmune condition that develops in genetically susceptible individuals and some data regarding T1D triggering factors appear to indicate that infections, mainly those due to viruses, play a major role. Accordingly, the use of viral live attenuated vaccines is being debated. In this narrative review, we discussed the most effective and safe use of vaccines in patients at risk of or with overt T1D. Literature analysis showed that several problems related to the use of vaccines in children with T1D have not been completely resolved. There are few studies regarding the immunogenicity and efficacy of vaccines in T1D children, and the need for different immunization schedules has not been precisely established. Fortunately, the previous presumed relationship between vaccine administration and T1D appears to have been debunked, though some doubts regarding rotavirus vaccines remain. Further studies are needed to completely resolve the problems related to vaccine administration in T1D patients. In the meantime, the use of vaccines remains extensively recommended in children with this disease.
Identifiants
pubmed: 34512622
doi: 10.3389/fimmu.2021.667889
pmc: PMC8427438
doi:
Substances chimiques
Vaccines, Attenuated
0
Viral Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
667889Informations de copyright
Copyright © 2021 Esposito, Mariotti Zani, Torelli, Scavone, Petraroli, Patianna, Predieri, Iughetti and Principi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Arch Intern Med. 2004 May 10;164(9):989-93
pubmed: 15136308
JAMA Pediatr. 2019 Mar 1;173(3):280-282
pubmed: 30667473
BMJ. 2011 Feb 03;342:d35
pubmed: 21292721
Med Sci Monit. 2002 Jul;8(7):CR516-9
pubmed: 12118201
Diabetologia. 2014 Oct;57(10):2193-200
pubmed: 25047648
Diabet Med. 1993 Jul;10(6):521-3
pubmed: 8395988
JAMA Pediatr. 2020 May 1;174(5):455-462
pubmed: 32150236
Diabetes Care. 2002 Oct;25(10):1778-83
pubmed: 12351477
Diabetes Care. 2010 Jul;33(7):1491-3
pubmed: 20587722
Exp Ther Med. 2015 Aug;10(2):693-698
pubmed: 26622377
J Infect Dis. 2020 Sep 1;222(7):1076-1083
pubmed: 32249284
Int J Mol Sci. 2020 Apr 22;21(8):
pubmed: 32331412
Front Endocrinol (Lausanne). 2015 Sep 14;6:134
pubmed: 26441826
Genes (Basel). 2017 Feb 16;8(2):
pubmed: 28212332
Vaccine. 2000 Nov 22;19(7-8):680-3
pubmed: 11115688
J Infect. 2020 Aug;81(2):e16-e25
pubmed: 32335169
J Pediatr Endocrinol Metab. 2003 Apr-May;16(4):495-508
pubmed: 12793601
Diabetologia. 2015 Nov;58(11):2592-5
pubmed: 26253765
Pediatr Endocrinol Rev. 2013 Dec;11(2):161-6
pubmed: 24575551
Clin Microbiol Rev. 2006 Jan;19(1):80-94
pubmed: 16418524
Chest. 2017 Jul;152(1):174-180
pubmed: 28434937
J Clin Virol. 2017 Nov;96:26-31
pubmed: 28934695
J Immunol. 2010 Feb 15;184(4):2204-10
pubmed: 20083660
Hum Vaccin Immunother. 2013 Sep;9(9):2002-6
pubmed: 23787761
Diabet Med. 1996 Jul;13(7):630-3
pubmed: 8840096
Diabetes Care. 2020 Nov;43(11):e170-e171
pubmed: 32816997
JAMA. 2016 May 3;315(17):1899-901
pubmed: 27139064
Sci Rep. 2019 Jun 13;9(1):7727
pubmed: 31197227
Nat Rev Endocrinol. 2019 Nov;15(11):635-650
pubmed: 31534209
Pediatr Endocrinol Diabetes Metab. 2009;15(4):227-32
pubmed: 20455416
J Postgrad Med. 2011 Jan-Mar;57(1):78-81
pubmed: 21206113
Clin Infect Dis. 2005 Aug 1;41(3):281-8
pubmed: 16007521
Pediatrics. 2001 Dec;108(6):E112
pubmed: 11731639
PLoS One. 2013 Apr 10;8(4):e60057
pubmed: 23593162
Diabetes Care. 2018 Oct;41(10):2127-2135
pubmed: 30104296
Am J Epidemiol. 1991 May 15;133(10):1024-31
pubmed: 1852097
JAMA Pediatr. 2013 Sep;167(9):808-15
pubmed: 23836309
Int J Endocrinol. 2015;2015:234358
pubmed: 26074959
Autoimmun Rev. 2016 Jul;15(7):644-8
pubmed: 26903475
Nature. 1992 Jul 9;358(6382):155-7
pubmed: 1377368
Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3988-91
pubmed: 11274421
J Diabetes Res. 2018 Nov 8;2018:7457269
pubmed: 30533447
Clin Exp Immunol. 2013 Feb;171(2):171-85
pubmed: 23286944
Diabetologia. 2009 Feb;52(2):369-70; author reply 373
pubmed: 19034414
Hum Vaccin Immunother. 2012 Apr;8(4):448-52
pubmed: 22370513
Diabetes Care. 2000 Oct;23(10):1516-26
pubmed: 11023146
Vaccine. 2009 Aug 27;27(39):5357-62
pubmed: 19607951
J Intern Med. 2014 Apr;275(4):398-408
pubmed: 24206418
Infect Dis Clin North Am. 1997 Sep;11(3):735-50
pubmed: 9378933
Rev Med Microbiol. 2019 Jan;30(1):1-17
pubmed: 30662163
Pediatr Infect Dis J. 2019 May;38(5):539-541
pubmed: 30986791
Diabetes Care. 2000 Jun;23(6):744-9
pubmed: 10840989
Trends Microbiol. 2003 Mar;11(3):101-5
pubmed: 12648936
BMJ. 1999 Oct 23;319(7217):1133
pubmed: 10531116
Diabetes. 2016 Jan;65(1):285-96
pubmed: 26450993
J Med Virol. 2002 Mar;66(3):340-50
pubmed: 11793386
Clin Immunol. 2002 Jun;103(3 Pt 1):249-59
pubmed: 12173299
JAMA Pediatr. 2013 Sep;167(9):800-7
pubmed: 23818010
J Pediatr Endocrinol Metab. 2002 Apr;15(4):389-95
pubmed: 12008685
J Clin Invest. 1994 Nov;94(5):2125-9
pubmed: 7962558
Diabetologia. 1987 Jun;30(6):397-401
pubmed: 3678660
Diabetes. 2000 Aug;49(8):1319-24
pubmed: 10923632
BMC Med. 2015 Mar 17;13:53
pubmed: 25857236
Infect Dis Clin North Am. 2001 Jun;15(2):407-21, viii
pubmed: 11447703
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Arch Dis Child. 1998 Jan;78(1):54-7
pubmed: 9534677
Endocr J. 2008 Jul;55(3):561-4
pubmed: 18520103
Acta Biomed. 2020 Sep 07;91(3):e2020033
pubmed: 32921727
JAMA Pediatr. 2020 Apr 1;174(4):383-385
pubmed: 31961393
FEMS Immunol Med Microbiol. 1999 Dec;26(3-4):259-65
pubmed: 10575137
Clin Immunol. 2015 Aug;159(2):143-53
pubmed: 26051037
Diabetes Care. 2021 Mar;44(3):699-706
pubmed: 33419932
Diabetologia. 2016 Feb;59(2):237-43
pubmed: 26564178
Vaccine. 2019 Mar 28;37(14):1938-1944
pubmed: 30827738
Autoimmun Rev. 2014 Jul;13(7):736-41
pubmed: 24468416
Clin Vaccine Immunol. 2016 Nov 4;23(11):873-877
pubmed: 27581437
Lancet. 1998 Feb 21;351(9102):568-9
pubmed: 9492780
Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17040-5
pubmed: 17942684
Diabetologia. 1991 Mar;34(3):176-81
pubmed: 1884889
Pediatr Diabetes. 2018 May;19(3):512-519
pubmed: 29094435
Front Immunol. 2018 May 17;9:1086
pubmed: 29868031
Autoimmun Rev. 2013 Mar;12(5):633-7
pubmed: 23277162
Curr Diabetes Rev. 2020;16(5):442-449
pubmed: 31657690
Autoimmunity. 1996;24(3):137-45
pubmed: 9020406
Diabetes. 2002 Dec;51(12):3353-61
pubmed: 12453886
Hum Vaccin Immunother. 2015;11(1):58-62
pubmed: 25483516
Indian J Endocrinol Metab. 2012 Mar;16 Suppl 1:S27-36
pubmed: 22701840
BMJ. 1999 May 1;318(7192):1169-72
pubmed: 10221937
Int J Antimicrob Agents. 2008 Feb;31 Suppl 1:S54-7
pubmed: 18054467
J Exp Med. 1995 Jun 1;181(6):1945-8
pubmed: 7539032
Diabet Med. 2011 Dec;28(12):1530-6
pubmed: 21916971
Pediatr Infect Dis J. 2017 Jul;36(7):674-675
pubmed: 28399059
Pneumonol Alergol Pol. 2015;83(5):401-8
pubmed: 26379004
Vaccine. 2017 Aug 24;35(36):4761-4768
pubmed: 28750853
Diabetes Care. 1997 May;20(5):767-72
pubmed: 9135940