Understanding Hyaluronan Receptor (CD44) Interaction, HA-CD44 Activated Potential Targets in Cancer Therapeutics.
Apoptosis
CD44
Cancer pathways
Cell proliferation
Hyaluronan
Nanotechnology
Targeted therapeutics
Tumor progression
Journal
Advanced pharmaceutical bulletin
ISSN: 2228-5881
Titre abrégé: Adv Pharm Bull
Pays: Iran
ID NLM: 101578021
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
15
03
2020
revised:
14
07
2020
accepted:
15
07
2020
entrez:
13
9
2021
pubmed:
14
9
2021
medline:
14
9
2021
Statut:
ppublish
Résumé
Cancer is a complex mechanism involving a series of cellular events. The glycoproteins such as hyaluronan (HA) are a significant element of extracellular matrix (ECM), involve in the onset of cancer developmental process. The pivotal roles of HA in cancer progression depend on dysregulated expression in various cancer. HA, also gain attention due to consideration as a primary ligand of CD44 receptor. The CD44, complex transmembrane receptor protein, due to alternative splicing in the transcription process, various CD44 isoforms predominantly exist. The overexpression of distinct CD44 isoforms (CD44v) standard (CD44s) depends on the tumour type and stage. The receptor proteins, CD44 engage in a variety of biological processes, including cell growth, apoptosis, migration, and angiogenesis. HA-CD44 interaction trigger survival pathways that result in cell proliferation, invasion ultimately complex metastasis. The interaction and binding of ligand-receptor HA-CD44 regulate the downstream cytoskeleton pathways involve in cell survival or cell death. Thus, targeting HA, CD44 (variant and standard) isoform, and HA-CD44 binding consider as an attractive and useful approach towards cancer therapeutics. The use of various inhibitors of HA, hyaluronidases (HYALs), and utilizing targeted Nano-delivery of anticancer agents and antibodies against CD44, peptides gives promising results
Identifiants
pubmed: 34513617
doi: 10.34172/apb.2021.050
pmc: PMC8421618
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
426-438Informations de copyright
©2021 The Authors.
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