A Genetic Variant of PPP1CB Influences Risk of Hepatitis B Virus-Related Hepatocellular Carcinoma in Han Chinese: A Pathway Based Analysis.
CTCF
HBV-related hepatocellular carcinoma
PPP1CB
SNP
cohesin
genome-wide association studies
Journal
Journal of hepatocellular carcinoma
ISSN: 2253-5969
Titre abrégé: J Hepatocell Carcinoma
Pays: New Zealand
ID NLM: 101674775
Informations de publication
Date de publication:
2021
2021
Historique:
received:
26
05
2021
accepted:
18
08
2021
entrez:
13
9
2021
pubmed:
14
9
2021
medline:
14
9
2021
Statut:
epublish
Résumé
Activation of actin cytoskeleton remodeling is an important stage preceding cancer cell metastasis. Previous genome-wide association studies (GWAS) have identified multiple hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC)-associated risk loci. However, limited sample size or strict significance threshold of GWAS may cause HBV-related HCC risk-associated genetic loci to be undetected. We aimed to investigate the performance of the SNP rs13025377 in We performed a case-control study including 1161 cases and 1353 controls to evaluate associations between single nucleotide polymorphisms (SNPs) from 98 actin-cytoskeleton regulatory genes and risk of HBV-related HCC. The effects of SNPs on HBV-related HCC risk were assessed under logistic regression model and corrected by false discovery rate (FDR). We found that rs13025377 in Thus, these findings indicated that
Identifiants
pubmed: 34513747
doi: 10.2147/JHC.S321939
pii: 321939
pmc: PMC8422165
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1055-1064Informations de copyright
© 2021 Mai et al.
Déclaration de conflit d'intérêts
Dr Jinlin Hou reports personal fees from AbbVie, Arbutus, Gilead Sciences, and Roche; grants, personal fees from Bristol Myers Squibb and Johnson&Johnson, outside the submitted work. The authors declare that they have no other competing interests.
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