Defective Severe Acute Respiratory Syndrome Coronavirus 2 Immune Responses in an Immunocompromised Individual With Prolonged Viral Replication.

COVID-19 SARS-CoV-2 cellular immunity humoral immunity immunocompromise lymphoma

Journal

Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045

Informations de publication

Date de publication:
Sep 2021
Historique:
received: 22 02 2021
accepted: 05 07 2021
entrez: 13 9 2021
pubmed: 14 9 2021
medline: 14 9 2021
Statut: epublish

Résumé

We describe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immune responses in a patient with lymphoma and recent programmed death 1 (PD-1) inhibitor therapy with late onset of severe coronavirus disease 2019 disease and prolonged SARS-CoV-2 replication, in comparison to age-matched and immunocompromised controls. High levels of HLA-DR

Identifiants

DOI: 10.1093/ofid/ofab359 PMID: 34514016 PMC: PMC8419740
pubmed: 34514016
doi: 10.1093/ofid/ofab359
pii: ofab359
pmc: PMC8419740
doi:

Types de publication

Journal Article

Langues

eng

Pagination

ofab359

Informations de copyright

© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

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Auteurs

Claire L Gordon (CL)

Department of Infectious Diseases, Austin Hospital, Heidelberg, Victoria, Australia.
Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.

Olivia C Smibert (OC)

Department of Infectious Diseases, Austin Hospital, Heidelberg, Victoria, Australia.
Department of Infectious Diseases, Peter McCallum Cancer Centre, Melbourne, Victoria, Australia.
National Centre for Infections in Cancer, Peter McCallum Cancer Centre, Melbourne, Victoria, Australia.

Natasha E Holmes (NE)

Department of Infectious Diseases, Austin Hospital, Heidelberg, Victoria, Australia.
Data Analytics Research and Evaluation Centre, Austin Health and University of Melbourne, Heidelberg, Victoria, Australia.

Kyra Y L Chua (KYL)

Department of Infectious Diseases, Austin Hospital, Heidelberg, Victoria, Australia.

Morgan Rose (M)

Department of Infectious Diseases, Austin Hospital, Heidelberg, Victoria, Australia.

George Drewett (G)

Department of Infectious Diseases, Austin Hospital, Heidelberg, Victoria, Australia.

Fiona James (F)

Department of Infectious Diseases, Austin Hospital, Heidelberg, Victoria, Australia.

Effie Mouhtouris (E)

Department of Infectious Diseases, Austin Hospital, Heidelberg, Victoria, Australia.

Thi H O Nguyen (THO)

Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.

Wuji Zhang (W)

Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.

Lukasz Kedzierski (L)

Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, Victoria, Australia.

Louise C Rowntree (LC)

Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.

Brendon Y Chua (BY)

Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.

Leon Caly (L)

Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.

Mike G Catton (MG)

Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.

Julian Druce (J)

Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.

Michelle Sait (M)

Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.

Torsten Seemann (T)

Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.

Norelle L Sherry (NL)

Department of Infectious Diseases, Austin Hospital, Heidelberg, Victoria, Australia.
Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.

Benjamin P Howden (BP)

Department of Infectious Diseases, Austin Hospital, Heidelberg, Victoria, Australia.
Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.

Katherine Kedzierska (K)

Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.

Jason C Kwong (JC)

Department of Infectious Diseases, Austin Hospital, Heidelberg, Victoria, Australia.
Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.

Jason A Trubiano (JA)

Department of Infectious Diseases, Austin Hospital, Heidelberg, Victoria, Australia.
Department of Infectious Diseases, Peter McCallum Cancer Centre, Melbourne, Victoria, Australia.
National Centre for Infections in Cancer, Peter McCallum Cancer Centre, Melbourne, Victoria, Australia.
Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.
Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia.

Classifications MeSH