Clinical Practice Guideline for Solid Organ Donation and Transplantation During the COVID-19 Pandemic.

Journal

Transplantation direct
ISSN: 2373-8731
Titre abrégé: Transplant Direct
Pays: United States
ID NLM: 101651609

Informations de publication

Date de publication:
Oct 2021
Historique:
received: 12 05 2021
revised: 03 06 2021
accepted: 05 06 2021
entrez: 13 9 2021
pubmed: 14 9 2021
medline: 14 9 2021
Statut: epublish

Résumé

The coronavirus 2019 (COVID-19) pandemic has disrupted health systems worldwide, including solid organ donation and transplantation programs. Guidance on how best to screen patients who are potential organ donors to minimize the risks of COVID-19 as well as how best to manage immunosuppression and reduce the risk of COVID-19 and manage infection in solid organ transplant recipients (SOTr) is needed. Iterative literature searches were conducted, the last being January 2021, by a team of 3 information specialists. Stakeholders representing key groups undertook the systematic reviews and generation of recommendations using a rapid response approach that respected the Appraisal of Guidelines for Research and Evaluation II and Grading of Recommendations, Assessment, Development and Evaluations frameworks. The systematic reviews addressed multiple questions of interest. In this guidance document, we make 4 strong recommendations, 7 weak recommendations, 3 good practice statements, and 3 statements of "no recommendation." SOTr and patients on the waitlist are populations of interest in the COVID-19 pandemic. Currently, there is a paucity of high-quality evidence to guide decisions around deceased donation assessments and the management of SOTr and waitlist patients. Inclusion of these populations in clinical trials of therapeutic interventions, including vaccine candidates, is essential to guide best practices.

Identifiants

DOI: 10.1097/TXD.0000000000001199 PMID: 34514110 PMC: PMC8425831
pubmed: 34514110
doi: 10.1097/TXD.0000000000001199
pmc: PMC8425831
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e755

Informations de copyright

Copyright © 2021 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc.

Déclaration de conflit d'intérêts

The authors have no relevant conflicts of interest to disclose.

Références

J Am Soc Nephrol. 2021 Feb;32(2):385-396
pubmed: 33154174
Am J Transplant. 2020 Nov;20(11):2989-2996
pubmed: 32476233
Am J Transplant. 2021 May;21(5):1801-1815
pubmed: 33040483
Gastroenterology. 2020 Sep;159(3):1176-1178.e2
pubmed: 32442561
Am J Transplant. 2020 Nov;20(11):3094-3105
pubmed: 32894641
Am J Transplant. 2021 Aug;21(8):2885-2889
pubmed: 33565705
Transplant Proc. 2020 Nov;52(9):2578-2583
pubmed: 32709414
Exp Clin Transplant. 2020 Oct;18(5):564-571
pubmed: 33143601
Clin Transplant. 2021 Jan;35(1):e14150
pubmed: 33170982
Transplantation. 2021 Jul 1;105(7):1405-1422
pubmed: 33724248
Health Res Policy Syst. 2018 Jul 13;16(1):63
pubmed: 30005679
Transplantation. 2020 Nov;104(11):2208-2214
pubmed: 32496357
JACC Case Rep. 2020 Jul 15;2(9):1347-1350
pubmed: 32835277
Am J Transplant. 2020 Jul;20(7):1837-1839
pubmed: 32359188
Liver Int. 2020 Aug;40(8):1972-1976
pubmed: 32471013
Transplantation. 2021 Jan 1;105(1):115-120
pubmed: 33350626
Am J Transplant. 2020 Jul;20(7):1849-1858
pubmed: 32301155
Pediatr Transplant. 2020 Dec;24(8):e13780
pubmed: 32542914
Am J Transplant. 2021 Jul;21(7):2623-2624
pubmed: 33756058
Transplantation. 2021 Jan 1;105(1):170-176
pubmed: 33093404
Intern Emerg Med. 2020 Nov;15(8):1507-1515
pubmed: 32979193
J Hepatol. 2021 Jan;74(1):148-155
pubmed: 32750442
J Hepatol. 2020 Nov;73(5):1063-1071
pubmed: 32526252
Transpl Int. 2020 Oct;33(10):1326-1328
pubmed: 32512629
Am J Transplant. 2020 Oct;20(10):2923-2927
pubmed: 32471004
Transplantation. 2021 Jan 1;105(1):14-17
pubmed: 33141806
Kidney Med. 2020 Jun 15;2(4):459-466
pubmed: 32775986
J Card Fail. 2020 Jun;26(6):457-461
pubmed: 32417380
Transpl Infect Dis. 2020 Dec;22(6):e13356
pubmed: 32510771
J Clin Epidemiol. 2017 Feb;82:47-60
pubmed: 27591906
Am J Transplant. 2020 Sep;20(9):2593-2598
pubmed: 32359194
N Engl J Med. 2020 Jun 18;382(25):2475-2477
pubmed: 32329975
CMAJ. 2010 Dec 14;182(18):E839-42
pubmed: 20603348
Am J Transplant. 2020 Nov;20(11):3173-3181
pubmed: 32529737
JAMA Cardiol. 2020 Oct 1;5(10):1165-1169
pubmed: 32402056
Clin Transplant. 2020 Jul;34(7):e13889
pubmed: 32396985
Kidney Int. 2020 Dec;98(6):1568-1577
pubmed: 33137341
J Am Soc Nephrol. 2020 Jun;31(6):1150-1156
pubmed: 32317402
Cochrane Database Syst Rev. 2020 Sep 30;9:CD013639
pubmed: 32997361
Transpl Infect Dis. 2020 Dec;22(6):e13359
pubmed: 32515076
Kidney Int. 2020 Dec;98(6):1540-1548
pubmed: 32979369
Transplant Direct. 2020 Jun 11;6(7):e572
pubmed: 32766427
Lancet Gastroenterol Hepatol. 2020 Aug;5(8):724-725
pubmed: 32505228
Can J Kidney Health Dis. 2020 Nov 13;7:2054358120967845
pubmed: 33240516
Am J Transplant. 2021 Apr;21(4):1576-1585
pubmed: 33043597
Am J Transplant. 2020 Nov;20(11):3008-3018
pubmed: 32780493
BMJ. 2016 Oct 12;355:i4919
pubmed: 27733354
Arch Public Health. 2014 Nov 10;72(1):39
pubmed: 25810908
Nephrol Dial Transplant. 2020 Dec 4;35(12):2083-2095
pubmed: 33275763
Transplantation. 2021 Apr 1;105(4):842-850
pubmed: 33394992
Nephrol Dial Transplant. 2020 Nov 1;35(11):1973-1983
pubmed: 33151337
Am J Transplant. 2020 Jul;20(7):1916-1921
pubmed: 32282986
Am J Transplant. 2020 Oct;20(10):2876-2882
pubmed: 32412159
Am J Transplant. 2020 Oct;20(10):2883-2889
pubmed: 32471001
Transpl Infect Dis. 2020 Dec;22(6):e13364
pubmed: 32521074
Lancet Respir Med. 2021 Mar;9(3):315-318
pubmed: 33275902
Clin J Am Soc Nephrol. 2020 Aug 7;15(8):1174-1178
pubmed: 32423908
EBioMedicine. 2020 Sep;59:102903
pubmed: 32718896
Am J Transplant. 2020 Nov;20(11):3225-3233
pubmed: 32476258
Transpl Infect Dis. 2020 Oct;22(5):e13353
pubmed: 32500942
Eur Urol. 2020 Oct;78(4):641-643
pubmed: 32624283
Am J Transplant. 2020 Nov;20(11):3106-3112
pubmed: 32476285
Kidney Int. 2020 Jun;97(6):1083-1088
pubmed: 32354634
Eur Urol. 2020 Jun;77(6):742-747
pubmed: 32249089
Transpl Infect Dis. 2021 Apr;23(2):e13503
pubmed: 33174324
Microorganisms. 2020 Jun 30;8(7):
pubmed: 32629788
Kidney Int Rep. 2020 Apr 04;5(5):580-585
pubmed: 32292866
Transpl Infect Dis. 2020 Dec;22(6):e13416
pubmed: 32681708
Pediatr Nephrol. 2020 Aug;35(8):1521-1524
pubmed: 32435879
Am J Transplant. 2020 Oct;20(10):2938-2941
pubmed: 32400013
Eur Urol. 2020 Jun;77(6):748-754
pubmed: 32317180
Am J Transplant. 2020 Jul;20(7):1819-1825
pubmed: 32351040
Radiology. 2020 Sep;296(3):E145-E155
pubmed: 32301646
Nephrol Dial Transplant. 2020 Jul 1;35(7):1250-1261
pubmed: 32678882
BMJ. 2008 May 10;336(7652):1049-51
pubmed: 18467413
BMJ Evid Based Med. 2020 Oct 1;:
pubmed: 33004426
Am J Transplant. 2020 Nov;20(11):3113-3122
pubmed: 32524743
Transpl Infect Dis. 2020 Dec;22(6):e13348
pubmed: 32500936
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
Eur Urol. 2020 Aug;78(2):281-286
pubmed: 32409114
Pediatr Transplant. 2021 May;25(3):e13868
pubmed: 32949098
Clin Nephrol. 2021 Apr;95(4):171-181
pubmed: 33560221
Exp Clin Transplant. 2020 Jun;18(3):275-283
pubmed: 32519618
Transplant Proc. 2021 May;53(4):1154-1159
pubmed: 33478747
Kidney Int Rep. 2020 May 01;5(6):905-909
pubmed: 32363253
Rev Assoc Med Bras (1992). 2020 Jul;66(7):880-888
pubmed: 32844930
Am J Transplant. 2020 Jul;20(7):1800-1808
pubmed: 32330343
Am J Transplant. 2020 Nov;20(11):3206-3209
pubmed: 32515085
J Clin Epidemiol. 2011 Apr;64(4):383-94
pubmed: 21195583
Transpl Int. 2020 Aug;33(8):969-970
pubmed: 32348586
Am J Transplant. 2020 Oct;20(10):2958-2959
pubmed: 32368838
Kidney Int Rep. 2021 Jan;6(1):46-55
pubmed: 33173838
Am J Transplant. 2020 Nov;20(11):3030-3041
pubmed: 32777153

Auteurs

Matthew J Weiss (MJ)

Transplant Québec, Montréal, QC, Canada.
CHU de Québec - Université Laval Research Center, Population Health and Optimal Health Practices Research Unit, Trauma-Emergency-Critical Care Medicine, Université Laval, QC, Canada.
Canadian Donation and Transplantation Research Program (CDTRP), Ottawa, ON, Canada.

Laura Hornby (L)

Canadian Donation and Transplantation Research Program (CDTRP), Ottawa, ON, Canada.
System Development - Organ and Tissue Donation and Transplantation, Canadian Blood Services, Ottawa, ON, Canada.

Farid Foroutan (F)

Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Ted Rogers Centre for Heart Research, Peter Munk Cardiac Centre, Toronto, ON, Canada.

Sara Belga (S)

Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

Simon Bernier (S)

Faculty of Medicine, Université Laval, QC, Canada.

Mamatha Bhat (M)

Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Multiorgan Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada.

C Arianne Buchan (CA)

Division of Infectious Diseases, Department of Medicine, University of Ottawa, Ottawa, ON, Canada.

Michael Gagnon (M)

Division of Nephrology and Multi-Organ Transplant Program, Department of Medicine, McGill University, Montreal, QC, Canada.

Gillian Hardman (G)

National Health Service Blood and Transplant, Bristol, United Kingdom.

Maria Ibrahim (M)

National Health Service Blood and Transplant, Bristol, United Kingdom.
Kings College, London, United Kingdom.

Cindy Luo (C)

Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.

Me-Linh Luong (ML)

Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montréal, QC, Canada.

Rahul Mainra (R)

Division of Nephrology, University of Saskatchewan, Saskatoon, SK, Canada.
St. Paul's Hospital, Saskatchewan Transplant Program, Saskatoon, SK, Canada.

Alex R Manara (AR)

National Health Service Blood and Transplant, Bristol, United Kingdom.
Department of Intensive Care Medicine, Southmead Hospital, Bristol, United Kingdom.

Ruth Sapir-Pichhadze (R)

Division of Nephrology and Multi-Organ Transplant Program, Department of Medicine, McGill University, Montreal, QC, Canada.
Centre for Outcomes Research and Evaluation, Research Institute of McGill University Health Centre, Montreal, QC, Canada.

Sarah Shalhoub (S)

Division of Infectious Diseases, Department of Medicine, Western University, London, ON, Canada.

Tina Shaver (T)

Southern Alberta Organ and Tissue Donation Program, Calgary, AB, Canada.

Jeffrey M Singh (JM)

Department of Medicine, University of Toronto, Toronto, Ontario, ON, Canada.
Trillium Gift of Life Network, Toronto, ON, Canada.

Sujitha Srinathan (S)

Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto, ON, Canada.

Ian Thomas (I)

National Health Service Blood and Transplant, Bristol, United Kingdom.
Department of Intensive Care Medicine, Southmead Hospital, Bristol, United Kingdom.

Lindsay C Wilson (LC)

System Development - Organ and Tissue Donation and Transplantation, Canadian Blood Services, Ottawa, ON, Canada.

T Murray Wilson (TM)

Transplant Research Foundation of British Columbia, Vancouver, BC, Canada.
Patient Partner, Canadian Donation and Transplantation Research Program.
The Alberta ORGANization Group, Edmonton, AB, Canada.

Alissa Wright (A)

Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

Allison Mah (A)

Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

Classifications MeSH